Article
Hematology
Lorenzo Loffredo, Gianpaolo Vidili, Angela Sciacqua, Chiara Cogliati, Rosella Di Giulio, Sciaila Bernardini, Paolo Ciacci, Antonello Pietrangelo, Federica Orlando, Aurora Paraninfi, Maria Boddi, Giovanni Di Minno, Lorenzo Falsetti, Corrado Lodigiani, Angelo Santoliquido, Evaristo Ettorre, Pasquale Pignatelli, Maria Felice Arezzo, Evghenii Gutu, Job Harenberg, Francesco Violi, AURELIO Study Grp
Summary: This study aimed to evaluate the risk factors for DVT in acutely ill hospitalized patients. The results showed that advanced age and active cancer were associated with ADVT at admission. Additionally, D-Dimer and IMPROVE-DD score were correlated with DVT development. Therefore, immediate CUS examination within 48 hours after admission may be necessary for patients with these risk factors.
THROMBOSIS JOURNAL
(2022)
Review
Hematology
Soravis Osataphan, Rushad Patell, Thita Chiasakul, Alok A. Khorana, Jeffrey Zwicker
Summary: This study evaluated the efficacy of extended thromboprophylaxis in 3655 medically ill patients with cancer, finding that the extended-duration group had a significantly higher risk of bleeding, but the rates of venous thromboembolic events were similar to the standard-duration group.
Article
Hematology
Rahel Villiger, Pauline Juillard, Pauline Darbellay Farhoumand, Damien Choffat, Tobias Tritschler, Odile Stalder, Jean-Benoit Rossel, Drahomir Aujesky, Marie Mean, Christine Baumgartner
Summary: This study validates the IMPROVE bleeding risk score, which has moderate to good discriminatory power in predicting bleeding in medical inpatients. The score can help identify patients at high risk of in-hospital bleeding, prompting careful assessment of the risk-benefit ratio of pharmacological thromboprophylaxis.
THROMBOSIS RESEARCH
(2023)
Review
Medicine, General & Internal
Samuel A. Berkman
Summary: There is a widespread concern about the lack of VTE prophylaxis for medically ill patients post-hospitalization, with slow implementation by physicians and hospitals. Factors such as recommendations against extended VTE prophylaxis in medical patients and the lack of approval for certain medications may contribute to this issue.
POSTGRADUATE MEDICINE
(2021)
Review
Hematology
Thita Chiasakul, Rushad Patell, Anthony Maraveyas, Marc Carrier, Jeffrey Zwicker
Summary: The incidence of VTE reported in chemotherapy RCTs in pancreatic cancer is significantly lower than what is reported in thromboprophylaxis studies. This indicates a lack of recognition of VTE in chemotherapeutic trials and underscores the importance of standardizing approaches to monitoring and reporting VTE in clinical trials.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Hematology
Omri Cohen, Orly Efros, Nicoletta Riva, Walter Ageno, Shelly Soffer, Eyal Klang, Assaf A. Barg, Gili Kenet, Sarina Levy-Mendelovich
Summary: In pediatric splanchnic vein thrombosis (SVT), anticoagulation appears to be associated with moderate recanalization rates and a low risk of major bleeding. The recurrence rate of venous thromboembolism (VTE) is low and comparable to that in pediatric patients with other types of provoked VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Deepa Arachchillage, Indika Rajakaruna, Zain Odho, Mike Makris, Mike Laffan
Summary: The controversy of post-discharge thromboprophylaxis in COVID-19 patients remains. This observational study across 26 NHS Trusts aimed to determine the impact of thromboprophylaxis on hospital acquired thrombosis (HAT) in discharged patients. The study found no difference in HAT between patients discharged with and without thromboprophylaxis, but increasing age and smoking significantly increased the risk of HAT.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Hematology
Emanuele Valeriani, Francesco Paciullo, Angelo Porfidia, Pasquale Pignatelli, Matteo Candeloro, Marcello Di Nisio, Marco Paolo Donadini, Claudio Maria Mastroianni, Roberto Pola, Paolo Gresele, Walter Ageno
Summary: Based on the analysis of multiple studies, anticoagulant therapy was found to have better efficacy in terms of visual acuity improvement and recurrent RVO events compared to antiplatelet therapy, but it also carried a certain risk of bleeding complications.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Nursing
Linjie Li, Yu Zhang, Peng Wang, Weelic Chong, Yang Hai, Ping Xu, Fang Fang
Summary: This study found that in acutely ill patients, conservative oxygen therapy was not associated with decreased mortality compared to liberal oxygen therapy, and there were no significant differences in good functional outcomes between the two oxygen therapies.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Review
Cardiac & Cardiovascular Systems
Mouhand F. H. Mohamed, Shaikha D. Al-Shokri, Khaled M. Shunnar, Sara F. Mohamed, Mostafa S. Najim, Shahd I. Ibrahim, Hazem Elewa, Lina O. Abdalla, Ahmed El-Bardissy, Mohamed Nabil Elshafei, Ibrahim Y. Abubeker, Mohammed Danjuma, Khalid M. Dousa, Mohamed A. Yassin
Summary: Recent studies have shown a high prevalence of VTE in critically ill COVID-19 patients, with nearly 50% of patients detected with VTE through systematic screening. Initial analysis suggests that prophylactic anticoagulation may significantly increase the risk of VTE compared to therapeutic anticoagulation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Xiaoye Li, Chengchun Zuo, Qiuyi Ji, Ying Xue, Zi Wang, Qianzhou Lv
Summary: This study compared the effectiveness and safety of dabigatran and rivaroxaban in different BMI populations, finding that rivaroxaban may carry a risk of insufficient anticoagulation effect in patients with high BMI. Obese patients may require an increased dose of rivaroxaban. Overall, the use of DOACs appears to be safe in obese patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Clinical Neurology
Shadi Yaghi, Ian J. Saldanha, Chelsea Misquith, Bashar Zaidat, Asghar Shah, Kareem Joudi, Bianca Persaud, Feras Abdul Khalek, Liqi Shu, Adam de Havenon, Eva A. Mistry, Ekaterina Bakradze, Eric D. Goldstein, John Reagan, Aikaterini Theodorou, Lina Palaiodimou, Karen Furie, Thalia S. Field, Georgios Tsivgoulis, Brian Mac Grory
Summary: This systematic review and meta-analysis suggest that DOACs and warfarin may have comparable efficacy and safety in patients with cerebral venous thrombosis. However, due to the limitations of the included studies, caution should be exercised in interpreting these findings until confirmation is obtained from ongoing randomized controlled trials and large, prospective, observational studies.
Review
Critical Care Medicine
Marija Barbateskovic, Olav L. Schjorring, Sara Russo Krauss, Christian S. Meyhoff, Janus C. Jakobsen, Bodil S. Rasmussen, Anders Perner, Jorn Wetterslev
Summary: In acutely ill adults, there is no significant difference in reducing mortality and adverse events between higher and lower oxygenation strategies, with low certainty evidence.
Review
Hematology
Allen Li, Ming Chan Zhang, Pei Li, Ali Eshaghpour, Katherine Li, Marc Carrier, Philip Wells, Mark Andrew Crowther
Summary: This study compared the efficacy and safety of direct oral anticoagulants (DOACs) with low-molecular-weight heparins (LMWHs), vitamin-k antagonists (VKAs), or no anticoagulation in patients with splanchnic vein thrombosis (SVT). The results showed that DOACs were more effective than VKAs in non-cirrhotic patients and had a reduced risk of major bleeding compared to observation, LMWHs, and VKAs. However, no difference in major bleeding was found between DOACs and other treatment options in cirrhotic patients.
THROMBOSIS RESEARCH
(2023)
Review
Peripheral Vascular Disease
Gerald Chi, Jane J. Lee, Sahar Memar Montazerin, Jolanta Marszalek
Summary: Elevated D-dimer levels are predictive of VTE occurrence within 90 days in acutely ill medical patients.
Letter
Endocrinology & Metabolism
Riemer A. Been, Andre P. van Beek, Rijk O. B. Gans, Peter R. van Dijk
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Anesthesiology
Sine Wichmann, Martin Schonemann-Lund, Anders Perner, Theis S. Itenov, Theis Lange, Christian Gluud, Rasmus E. Berthelsen, Anne C. Brochner, Jorgen Wiis, Morten H. Bestle
Summary: This study aimed to evaluate the effects of diuretics on fluid overload in ICU patients. The results showed that diuretics did not have a significant impact on the number of days alive and out of hospital at 90 days.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Review
Multidisciplinary Sciences
Jehad Barakji, Steven Kwasi Korang, Joshua Feinberg, Mathias Maagaard, Ole Mathiesen, Christian Gluud, Janus Christian Jakobsen
Summary: This study assessed the benefits and harms of cannabinoids in pain patients. The results showed that cannabinoids reduced chronic pain and improved quality of sleep, but the effect sizes were small. However, cannabinoids had no effects on acute pain or cancer pain and increased the risks of non-serious adverse events. The harmful effects of cannabinoids seem to outweigh the potential benefits in pain treatment.
Article
Medicine, Research & Experimental
Anders Kirkegaard-Klitbo, Daniel Monsted Shabanzadeh, Markus Harboe Olsen, Jane Lindschou, Christian Gluud, Lars Tue Sorensen
Summary: This study aims to compare the effectiveness of the one-step approach and the two-step approach in treating common bile duct stones. A total of 150 participants will be randomly assigned to either the one-step approach or the two-step approach. The primary outcome measure is the occurrence of postoperative complications within 90 days.
PILOT AND FEASIBILITY STUDIES
(2023)
Letter
Biochemistry & Molecular Biology
Anne F. Brunger, Ronald van Rheenen, Reinold O. B. Gans, Bouke P. C. Hazenberg, Hans L. A. Nienhuis
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2023)
Article
Surgery
Leonie Rosien, Peter. R. van Dijk, Jacques Oskam, Maurice E. N. Pierie, Klaas H. Groenier, Rijk O. B. Gans, Henk J. G. Bilo
Summary: The objective of this study was to describe the lower extremity amputation rates in people with diabetes in the Zwolle region, where footcare is organized according to international guidelines. The results showed a considerable decrease in the incidence rate of major and minor amputations among people with diabetes in this region.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Medicine, Research & Experimental
Isak Mazanti Cold, Joshua Buron Feinberg, Axel Brandes, Ulla Davidsen, Ulrik Dixen, Helena Dominguez, Uffe Jakob Ortved Gang, Christian Gluud, Rakin Hadad, Kit Engedal Kristensen, Doan Tuyet van Le, Emil Eik Nielsen, Michael Hecht Olsen, Ole Dyg Pedersen, Ilan Esra Raymond, Ahmad Sajadieh, Anne Merete Boas Soja, Janus Christian Jakobsen
Summary: This study aims to compare strict rate control with lenient rate control in patients with atrial fibrillation. The primary outcome is the physical component score of the SF-36 questionnaire. All secondary outcomes will be hypothesis-generating. The analysis will be based on the intention-to-treat principle and use linear regression for adjustment.
Review
Medicine, General & Internal
Caroline Kamp Jorgensen, Sophie Juul, Faiza Siddiqui, Mark Abie Horowitz, Joanna Moncrieff, Klaus Munkholm, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen
Summary: This study aims to assess the risks of adverse events with venlafaxine or mirtazapine in adults with major depressive disorder through systematic reviews. The effects of venlafaxine and mirtazapine will be evaluated separately in two reviews. The assessment of bias risk will be conducted using the Cochrane risk-of-bias tool version 2, and clinical significance will be assessed using an eight-step procedure. The results of this study will provide important information for the treatment of major depressive disorder.
SYSTEMATIC REVIEWS
(2023)
Letter
Biochemistry & Molecular Biology
Anne F. Brunger, Hans L. A. Nienhuis, Johan Bijzet, Evelien Zonneveld-Huijssoon, Jan S. F. Sanders, Geertje E. Legger, Reinold O. B. Gans, Bouke P. C. Hazenberg
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2023)
Article
Endocrinology & Metabolism
Annel Lameijer, Julia J. Bakker, Kalvin Kao, Yongjin Xu, Rijk. O. B. Gans, Henk J. G. Bilo, Timothy C. Dunn, Peter R. van Dijk
Summary: This study aimed to evaluate the real-life changes in glycemic parameters among FLASH users who did not achieve glycemic targets. De-identified data from patients using FLASH for a continuous 24-week period were analyzed, and significant improvements were observed in glycemic parameters in most analyses, regardless of initial glycemic regulation or treatment modality.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Letter
Medicine, General & Internal
John Kellett, Niclas Skyttberg, Rijk Gans, Frank Sebat, Runolfur Palsson
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Transplantation
Dion Groothof, Naser B. N. Shehab, Adrian Post, Reinold O. B. Gans, Stephan J. L. Bakker, Nicole S. Erler
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Hematology
Louise H. Hooimeijer, Marjet A. Stein-Wit, Marja A. J. Voskuilen, Michael Lukens, Karina Meijer, Anja B. U. Makelburg, Rienk Y. J. Tamminga
Summary: In 2018, Refacto AF(R) became our preferential product. We prospectively monitored the development of inhibitors and retrospectively sought for risk factors in patients who developed inhibitors. Over a period of 15 months, 4/19 adult patients with non-severe hemophilia developed high titer antibodies after treatment with Refacto AF(R), and 5/52 mostly severe patients developed an inhibitor after switching to Refacto AF(R). We concluded that inhibitors were encountered in on demand and previously treated prophylaxis patients, and risk factors such as genotype, surgery, and immunogenicity of Refacto AF(R) should be considered.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Article
Hematology
Soerajja Bhoelan, Jaime Borjas Howard, Vladimir Tichelaar, Wouter Bierman, Karina Meijer
Summary: The trends of coagulation parameters during long-term treatment with combination antiretroviral therapy (cART) are unclear. This study followed 40 male subjects living with human immunodeficiency virus (HIV) and found that procoagulant parameters were initially elevated but decreased during the first year of cART treatment. However, at year 9, an increase in these parameters was observed, which may be related to established cardiovascular risk factors.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Review
Critical Care Medicine
Nina Christine Andersen-Ranberg, Marija Barbateskovic, Anders Perner, Marie Oxenboll Collet, Lone Musaeus Poulsen, Mathieu van der Jagt, Lisa Smit, Jorn Wetterslev, Ole Mathiesen, Mathias Maagaard
Summary: By reviewing recent trials, we found that haloperidol may reduce mortality and have minimal impact on serious adverse events in critically ill patients with delirium. However, further trial data is needed to confirm the effects of haloperidol in these patients.