Article
Obstetrics & Gynecology
Yutaka Osuga, Yoshifumi Seki, Masataka Tanimoto, Takeru Kusumoto, Kentarou Kudou, Naoki Terakawa
Summary: This study evaluated the efficacy and safety of relugolix in treating endometriosis-associated pain, showing that oral administration of relugolix alleviated pain in a dose-response manner and was generally well tolerated. Relugolix demonstrated efficacy and safety comparable to leuprorelin, another treatment option.
FERTILITY AND STERILITY
(2021)
Article
Medicine, Research & Experimental
Shan Liu, Ya-Su Lv, Shuo Han, Minghui Liu, Shuai Ma, Haiying Ren, Yuan Li
Summary: This study aims to compare the LH-based flexible GnRH antagonist protocol and traditional flexible GnRH antagonist protocol for PCOS patients to determine if there is a significant difference in cumulative ongoing pregnancy rates. The primary efficacy endpoint is the cumulative ongoing pregnancy rate per cycle.
Article
Obstetrics & Gynecology
Liting Zhang, He Cai, Xitong Liu, Yao Xiong, Xiaoling Liang, Juanzi Shi
Summary: This study compared the pregnancy outcomes of infertile women with adenomyosis under different treatment protocols and found that there were no significant differences in clinical pregnancy rate, live birth rate, and cumulative live birth rate between the GnRH antagonist protocol with freeze-all strategy group and the long-acting GnRH agonist protocol group.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Endocrinology & Metabolism
Yubin Li, Yuwei Duan, Xi Yuan, Bing Cai, Yanwen Xu, Yuan Yuan
Summary: A novel nomogram has been developed to accurately predict the gonadotropin starting dose in GnRH antagonist protocol, with a high accuracy rate. The multivariate regression model based on AMH level, AFC, and BMI can explain 59% of the variability of ovarian sensitivity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yifan Chu, Luyao Wang, Jiaxin Xie, Shulin Yang, Si Liu, Dan Hu, Jing Yue
Summary: This study aims to evaluate the impact of growth hormone (GH) on IVF/ICSI outcomes and endometrial receptivity in patients undergoing GnRH-ant protocol with fresh embryo transfer. It will also explore the possible mechanism of GH in improving pregnancy outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Shaomi Zhu, Zhexi Lv, Linjiang Song, Qinxiu Zhang, Yiyue Fan, Junjun Li
Summary: This study conducted a systematic review and meta-analysis to examine the impact of estradiol pretreatment on reproductive outcomes and ovary stimulation characteristics in IVF/ICSI treatment with GnRH antagonist protocol. The results showed that luteal estradiol pretreatment did not affect reproductive outcomes in patients with normal ovarian response in GnRH antagonist protocol.
Article
Obstetrics & Gynecology
Tasuku Harada, Yutaka Osuga, Yusuke Suzuki, Masaki Fujisawa, Motoko Fukui, Jo Kitawaki
Summary: This study evaluated the efficacy and safety of 40-mg relugolix compared with leuprorelin in treating endometriosis-associated pain. The results demonstrated that relugolix was noninferior to leuprorelin in relieving pelvic pain, and both medications had comparable safety profiles.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Sara Fernandez-Prada, Maria Martin-Camean, Onica Armijo, Jesus Diez-Sebastian, Silvia Iniesta, Sonia Lobo, Patricia Silva, Clara Sanz, Maria Jose Sanchez, Alicia Hernandez
Summary: While no significant differences in pregnancy rates were found between groups, the E2 group showed a trend towards worse gestational outcomes. This study supports previous findings and suggests that longer exposure to estrogen pre-treatment may lead to better pregnancy outcomes. Further research may explore the optimal timing of this treatment in clinical practice.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Endocrinology & Metabolism
Shan Liu, Minghui Liu, Lingxiu Li, Huanhuan Li, Danni Qu, Haiying Ren, Hui Su, Yang Zhang, Yuan Li
Summary: A retrospective cohort study on 110 patients with deep ovarian suppression found that a modified GnRH antagonist protocol based on LH levels during the second ovarian stimulation cycle resulted in significantly better reproductive outcomes compared to continuing with GnRH agonist long protocol. The use of modified protocol led to higher ongoing pregnancy and live birth rates, and lower cancellation rate, suggesting that patients may benefit from adjusting their treatment based on LH levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Apoorva Nisal, Urmila Diwekar, Elie Hobeika
Summary: This article discusses the importance of superovulation in the IVF process and the need for customized dosage protocols, as well as the development of a mathematical algorithm to provide personalized superovulation models.
COMPUTERS & CHEMICAL ENGINEERING
(2022)
Article
Pharmacology & Pharmacy
Oliver Pohl, Kyle Baron, Matthew Riggs, Jonathan French, Ramon Garcia, Jean-Pierre Gotteland
Summary: This study aimed to identify the appropriate dosage range of linzagolix to relieve endometriosis-related pelvic pain and protect bone health. The results suggested that a daily dose of 75-125 mg linzagolix may achieve the targets of pain relief, efficacy, and bone mineral density loss in Caucasian patients.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Jieru Zhu, Weijie Xing, Tao Li, Hui Lin, Jianping Ou
Summary: The study evaluated the clinical outcomes and maternal-neonatal safety of gonadotropin releasing hormone antagonist (GnRH-ant) and gonadotropin releasing hormone agonist (GnRH-a) protocols. The results showed that GnRH-ant protocol was comparable to GnRH-a protocol in clinical outcomes and obstetric and perinatal outcomes, with a lower risk of ovarian hyperstimulation syndrome (OHSS).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jianing Xu, Cuilian Zhang, Shuna Wang, Shaodi Zhang
Summary: This study investigated the impact of progesterone concentration on clinical outcomes in blastocyst transfer cycles with an antagonist protocol. It found a significant association between progesterone concentration and clinical pregnancy rate, particularly in blastocyst transfer. The relationship between progesterone concentration and ongoing pregnancy rate was insignificant. The study also identified a curvilinear relationship between progesterone concentration and pregnancy outcomes, with the optimal threshold being 0.80 ng/mL.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marie-Madeleine Dolmans, Jacques Donnez
Summary: Endometriosis is a chronic inflammatory disease that requires lifelong management. This review evaluates the pathways involved in endometriosis and explores new therapies. Inflammation and inflammatory molecules play a crucial role in the disease, and targeting inflammation, nuclear factor kappa B and cytokines, as well as pathways related to apoptosis and autophagy, may offer new perspectives for non-hormonal treatment.
Article
Obstetrics & Gynecology
Eissa Khalifa, Hashem Mohammad, Ameer Abdullah, Mazen Abdel-Rasheed, Mohammed Khairy, Mahmoud Hosni
Summary: This study suggests that Dienogest is a suitable and safe alternative to GnRHa pretreatment in patients with endometriosis, with lower cost, fewer side effects, higher FertiQoL treatment scores, and better tolerability.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Shannon Pretzel, Katherine Kuhn, Lubna Pal, Alex Polotsky, Hugh S. Taylor, Heping Zhang, Jared Robins, Steven L. Young, Nanette Santoro
Summary: Recruitment for an endometriosis clinical trial using an electronic medical record (EMR)-based strategy is feasible, although the overall yield of participants is low. Delays in treatment due to COVID-19 did not appear to overly influence potential recruitment.
REPRODUCTIVE SCIENCES
(2022)
Article
Reproductive Biology
Yeon Jeong Hwang, Gi-Jun Sung, Ryan Marquardt, Steven L. Young, Bruce A. Lessey, Tae Hoon Kim, Yong-Pil Cheon, Jae-Wook Jeong
Summary: This study reveals the temporal expression pattern of SIRT1 in the mouse uterus and demonstrates its important role in uterine function, decidualization, and key molecules involved in implantation.
BIOLOGY OF REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Abigail Combs, Bhuchitra Singh, Elisabeth Nylander, Md Soriful Islam, Ha Vi Nguyen, Elissa Parra, Ameerah Bello, James Segars
Summary: Vitamin D has emerged as a potential therapy for uterine fibroids based on experimental and clinical evidence. It has been found to decrease proliferation and Wnt/beta-catenin signaling in fibroid cells, and studies have shown its effectiveness in prevention and treatment of fibroids.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Kathleen E. O'Neill, Jacqueline Y. Maher, Monica M. Laronda, Francesca E. Duncan, Richard D. LeDuc, Marla E. Lujan, Kutluk H. Oktay, Alison M. Pouch, James H. Segars, Elizabeth L. Tsui, Mary B. Zelinski, Lisa M. Halvorson, Veronica Gomez-Lobo
Summary: This article introduces the conceptualization process and outcomes of an effort to standardize ovarian nomenclature and define the organ's features. The goal was to develop a spatially defined and semantically consistent terminology of the ovary to support collaborative, team science-based endeavors aimed at generating reference atlases of the human ovary. The new systems of nomenclature and mapping will better reflect the ovary's heterogeneous composition and function, support the standardization of tissue collection, facilitate functional analyses, and enable clinical and research collaborations.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Joshua M. Morris, Angela Liang, Katarina Fleckenstein, Bhuchitra Singh, James Segars
Summary: This systematic review analyzed the effectiveness of minimally invasive approaches to treat fibroids and compared their impact on quality of life and symptoms. The results showed that radiofrequency ablation and ultrasound-guided sclerotherapy significantly improved quality of life, while uterine artery embolization and ultrasound-guided high-intensity frequency ultrasound had similar effects as surgical interventions. Minimally invasive approaches were effective alternatives to surgery for improving quality of life and fibroid-associated symptoms.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Kamaria C. Cayton Vaught, Dana Hazimeh, Ashlie Sewdass Carter, Kate Devine, Jacqueline Y. Maher, Marcy Maguire, Elizabeth A. McGee, Paul H. Driggers, James H. Segars
Summary: This study found that AKAP13 may function as a scaffolding protein in follicle-stimulating hormone (FSH) signal transduction by interacting with CREB, leading to phosphorylation of CREB.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Bhuchitra Singh, Julia Berry, Michelle Volovsky, Yanqing Xu, Ahmed M. Soliman, Carol B. Thompson, James H. Segars
Summary: The objective of this study was to evaluate the utility and impact of the Painful Periods Screening Tool (PPST) to improve healthcare delivery for people with symptoms of pelvic pain. The results showed that most participants reported severe pain during menstruation, and using the PPST helped them discuss their symptoms more easily with healthcare providers.
REPRODUCTIVE SCIENCES
(2023)
Article
Nutrition & Dietetics
Hiba Siblini, Ayman Al-Hendy, James Segars, Frank Gonzalez, Hugh S. Taylor, Bhuchitra Singh, Ainna Flaminia, Valerie A. Flores, Gregory M. Christman, Hao Huang, Jeremy J. Johnson, Heping Zhang
Summary: This is an abstract of preliminary results from a clinical study on the use of EGCG for treating unexplained infertility associated with uterine fibroids. The study found that a daily dose of 800 mg of EGCG alone or in combination with clomiphene citrate or letrozole (for 5 days) is well-tolerated and not associated with liver toxicity or folate deficiency in reproductive-aged women.
Article
Obstetrics & Gynecology
Eduardo Hariton, Ruben Alvero, Micah J. Hill, Jennifer E. Mersereau, Shana Perman, David Sable, Fiona Wang, Geoffrey David Adamson, Christos Coutifaris, LaTasha B. Craig, Pardis Hosseinzadeh, Anthony N. Imudia, Erica B. Johnstone, Ruth B. Lathi, Paul C. Lin, Erica E. Marsh, Michele Munch, Gloria Richard-Davis, Lauren W. Roth, Amy K. Schutt, Kim Thornton, Lauren Verrilli, Rachel S. Weinerman, Steven L. Young, Kate Devine
Summary: The field of reproductive endocrinology and infertility faces a mismatch between demand and availability of care. It is recommended to increase the number of qualified physicians and non-REI providers to address the physician shortage problem and improve clinical efficiency through technological improvements.
FERTILITY AND STERILITY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Audrey Oarneau, Anthony Bui, Steven L. Young, Genevieve S. Neal-Perry
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Rachel Catharine Wilson, Heather M. Sidener, Lauren Drew Martin, Jeanne Link, Steven L. Young, Ov D. Slayden
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Anthony Bui, Audrey Garneau, Steven L. Young
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Audrey Garneau, Anthony Bui, Douglas Timmons, Caitlin Boylan, Steven L. Young
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Aydogan B. Mathyk, F. Alvarado, S. L. Young, A. Beheshti, A. M. Quaas
FERTILITY AND STERILITY
(2022)
Review
Obstetrics & Gynecology
Anthony H. Bui, Douglas B. Timmons, Steven L. Young
Summary: This review succinctly examines the mechanisms of implantation and luteal phase endometrial differentiation, the causes of impaired endometrial function and receptivity, and the current methods for evaluating and treating impaired endometrial receptivity. Although there is an understanding of some mechanisms of impaired endometrial receptivity, treatment options remain limited.
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
(2022)