Article
Oncology
Tianyuan Liu, Xuan Zhao, Yuan Lin, Qi Luo, Shaosen Zhang, Yiyi Xi, Yamei Chen, Lin Lin, Wenyi Fan, Jie Yang, Yuling Ma, Alok K. Maity, Yanyi Huang, Jianbin Wang, Jiang Chang, Dongxin Lin, Andrew E. Teschendorff, Chen Wu
Summary: This study develops a computational strategy to identify stem-like preneoplastic cells that may drive cancer progression by dissecting the heterogeneity of differentiation states within a preneoplastic cell population.
Article
Neurosciences
Feifei Luo, Yifu Liao, Endong Cao, Yong Yang, Kai Tang, Dexiang Zhou, Dong Zhou, Haiping Cai
Summary: This study found that HIC2 gene is hypermethylated and expressed at low levels in glioma. Hypermethylation and low expression of HIC2 predict poor prognosis. Further experiments showed that HIC2 inhibits glioma proliferation in vitro and in vivo by interacting with RNF44 and PTPRN2.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Chan Wang, Jiaxin Chen, Yeye Kuang, Xiaoqing Cheng, Min Deng, Zhinong Jiang, Xiaotong Hu
Summary: The study found that TRPM4 is a novel methylated tumor suppressor gene that is downregulated in colorectal cancer. TRPM4 activates calpain-mediated cleavage of FAK through modulating the PI3K/Akt/mTOR signaling cascade, thereby impeding CRC migration and invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Genetics & Heredity
Melva Gutierrez-Angulo, Maria de la Luz Ayala-Madrigal, Jose Miguel Moreno-Ortiz, Jorge Peregrina-Sandoval, Fernando Daniel Garcia-Ayala
Summary: Colorectal cancer is a complex disease influenced by genetics, epigenetics, and environmental factors. DNA methylation, particularly in tumor suppressor genes, plays a role in the development of cancer. The composition of gut microbiota, including enrichment of certain bacteria like Fusobacterium nucleatum and Hungatella hathewayi, is associated with changes in DNA methylation patterns in colorectal cancer. These changes can affect gene expression and impact the prognosis of colorectal cancer patients.
FRONTIERS IN GENETICS
(2023)
Article
Chemistry, Analytical
Pengcheng Sun, Kai Niu, Haiying Du, Ruixin Li, Jiping Chen, Xianbo Lu
Summary: The study presents an electrochemical gene-sensor capable of rapidly and sensitively detecting tumor related TP53 gene mutation hotspots. The biosensor achieves high sensitivity and specificity, making it a powerful tool for early diagnosis and detection of cancer.
Review
Gastroenterology & Hepatology
JianRu Wen, SiXiu Deng, YuHua Bi, LiJuan Qiao, Hui Xu
Summary: This study aims to investigate the correlation between the methylation status of multiple gene promoters and gastric cancer. The results show that a higher frequency of CpG islands methylation was identified in gastric cancer tissues, suggesting that aberrant polygene methylation might be associated with the initial onset and progression of gastric cancer. Therefore, the DNA methylation of these genes may serve as underlying epigenetic biomarkers, providing a promising molecular diagnostic approach for human gastric cancer clinical diagnosis.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Multidisciplinary Sciences
Xiaojing Chang, Jinguo Ma, Xiaoying Xue, Guohui Wang, Tianfang Yan, Linlin Su, Xuetao Han, Huandi Zhou, Liubing Hou
Summary: The study revealed that in gastric cancer patients, the down-regulation of NDRG1 expression was negatively correlated with DNMT1, DNMT3A, and DNMT3B, while the DNA methylation of NDRG1 was positively correlated with the DNMT family. High expression of NDRG1 may be associated with prolonged overall survival.
Article
Cell Biology
Weilin Sun, Gang Ma, Li Zhang, Pengliang Wang, Nannan Zhang, Zizhen Wu, Yinping Dong, Fenglin Cai, Liqiao Chen, Huifang Liu, Han Liang, Jingyu Deng
Summary: ADAMTS9 in gastric cancer cells exerts inhibitory effects, with its decreased expression associated with malignant phenotypes and poor prognosis. Restoration of ADAMTS9 significantly suppressed the viability and motility of GC cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Arnaud Carrier, Cecile Desjobert, Valerie Lobjois, Lise Rigal, Florence Busato, Jorg Tost, Miquel Ensenyat-Mendez, Diego M. Marzese, Anne Pradines, Gilles Favre, Laurence Lamant, Luisa Lanfrancone, Chantal Etievant, Paola B. Arimondo, Joelle Riond
Summary: Protocadherin proteins play an important role in cell adhesion and signaling pathways. The study found that the PCDHB15 gene's specific exon is hypermethylated in melanoma, leading to its silencing. This silencing contributes to the aggressiveness of melanoma.
CLINICAL EPIGENETICS
(2022)
Review
Biochemistry & Molecular Biology
Ting Xu, Hongmei Ding, Jie Chen, Jiahui Lei, Meng Zhao, Bingyu Ji, Youguo Chen, Songbing Qin, Qinqin Gao
Summary: This article provides an update on the roles of aberrant DNA methylation in endometrial carcinogenesis and discusses the opportunities and challenges of utilizing DNA methylation in the management and prevention of endometrial cancer.
Article
Biophysics
Dongfei Chen, Yanfang Wu, Richard D. Tilley, J. Justin Gooding
Summary: An ultra-sensitive and highly-selective electrochemical biosensor has been developed for rapid detection of DNA methylation in blood, providing a promising method for minimally invasive diagnosis of ovarian cancer.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Multidisciplinary Sciences
Mita T. M. T. Tran, Kun-Tu Yeh, Yu-Ming Chuang, Po-Yen Hsu, Jie-Ting Low, Himani Kumari, Yu-Ting Lee, Yin-Chen Chen, Wan-Hong Huang, Hongchuan Jin, Shu-Hui Lin, Michael W. Y. Chan
Summary: Gastric cancer is a major cause of cancer death globally. The study found that STAT3 activation is important for gastric cancer development and C11orf87 methylation may serve as a biomarker for diagnosis and prognosis of gastrointestinal cancers. In patients with higher C11orf87 methylation, better survival was observed, indicating a potential role of epigenetic regulation in STAT3 inhibition in gastric cancer.
Article
Chemistry, Analytical
Jingyi Guo, Mei Zhao, Chen Chen, Fang Wang, Zilin Chen
Summary: This study developed a novel biosensor for the detection of N6-methyladenosine and 5-methylcystosine-single strand DNA using a laser-induced graphene electrode. The biosensor exhibited low detection limits, a wide linear detection range, and good selectivity, stability, and reproducibility. The successful application of this method suggests its potential for clinical diagnosis and the development of point-of-care testing techniques.
Article
Biophysics
Jingting Wang, Xu Yang, Mengyao Cui, Yiliang Liu, Xiaoyun Li, Lixia Zhang, Guoqiang Zhan
Summary: A highly sensitive electrochemical sensor based on Geobacter-dominated biofilms was developed for detecting low concentrations of heavy metals. The sensor showed high sensitivity for Cd2+ and Pb2+ detection, and the full-area model provided the best fit for biosensor response.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biology
Marion Rosello, Juliette Vougny, Francois Czarny, Marina C. Mione, Jean-Paul Concordet, Shahad Albadri, Filippo Del Bene
Summary: Researchers have successfully generated precise point mutations in zebrafish models using gene editing technology, mimicking oncogenic mutations in human genes and creating new disease models.