[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer's disease patients

(2020) Estelle Schueller et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

(2020) Ping-Chieh Pao et al.   Nature Communications

Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau

(2019) Hyeanjeong Jeong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer’s Disease

(2018) Laura Mahady et al.   JOURNAL OF ALZHEIMERS DISEASE

Spatial analysis and high resolution mapping of the human whole-brain transcriptome for integrative analysis in neuroimaging

(2018) Gregor Gryglewski et al.   NEUROIMAGE

In vivo quantification of neurofibrillary tangles with [18F]MK-6240

(2018) Tharick A. Pascoal et al.   Alzheimers Research & Therapy

Correlation of In Vivo [18F]Flortaucipir With Postmortem Alzheimer Disease Tau Pathology

(2018) Ruben Smith et al.   JAMA Neurology

The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

(2017) Hidekuni Yamakawa et al.   Cell Reports

The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer’s disease

(2017) Shuang-shuang Yang et al.   Translational Neurodegeneration

Comparability of [18F]THK5317 and [11C]PIB blood flow proxy images with [18F]FDG positron emission tomography in Alzheimer’s disease

(2016) Elena Rodriguez-Vieitez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease

(2016) T A Pascoal et al.   MOLECULAR PSYCHIATRY

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer’s Disease Mice

(2016) Mar Cuadrado-Tejedor et al.   NEUROPSYCHOPHARMACOLOGY

Insights into neuroepigenetics through human histone deacetylase PET imaging

(2016) Hsiao-Ying Wey et al.   Science Translational Medicine

VoxelStats: A MATLAB Package for Multi-Modal Voxel-Wise Brain Image Analysis

(2016) Sulantha Mathotaarachchi et al.   Frontiers in Neuroinformatics

Kinetic Analysis and Quantification of [11C]Martinostat for in Vivo HDAC Imaging of the Brain

(2015) Hsiao-Ying Wey et al.   ACS Chemical Neuroscience

Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET

(2015) Y. J. Chen et al.   JOURNAL OF NUCLEAR MEDICINE

Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain

(2015) Kyle W. Anderson et al.   PLoS One

c-Abl Stabilizes HDAC2 Levels by Tyrosine Phosphorylation Repressing Neuronal Gene Expression in Alzheimer’s Disease

(2014) Marcelo Gonzalez-Zuñiga et al.   MOLECULAR CELL

Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency

(2014) Bihua Bie et al.   NATURE NEUROSCIENCE

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

HDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levels

(2014) Yindi Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking

(2014) Rogier A. Kievit et al.   Nature Communications

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A , and Frank Neuronal Loss

(2013) R. M. Cohen et al.   JOURNAL OF NEUROSCIENCE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Modeling Alzheimer’s disease in transgenic rats

(2013) Sonia Do Carmo et al.   Molecular Neurodegeneration

Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero

(2013) K Matthew Lattal et al.   NATURE NEUROSCIENCE

Histone acetylation: molecular mnemonics on the chromatin

(2013) Johannes Gräff et al.   NATURE REVIEWS NEUROSCIENCE

Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies

(2012) Ing-Tsung Hsiao et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

(2012) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Clinical Validation of 18F-AZD4694, an Amyloid- -Specific PET Radioligand

(2012) Z. Cselenyi et al.   JOURNAL OF NUCLEAR MEDICINE

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Epigenetic mechanisms in neurological disease

(2012) Mira Jakovcevski et al.   NATURE MEDICINE

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

The importance of appropriate partial volume correction for PET quantification in Alzheimer’s disease

(2011) Benjamin A. Thomas et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Chronic divalproex sodium use and brain atrophy in Alzheimer disease

(2011) A. S. Fleisher et al.   NEUROLOGY

Targeting HDACs: A Promising Therapy for Alzheimer's Disease

(2011) Ke Xu et al.   Oxidative Medicine and Cellular Longevity

Brain function and chromatin plasticity

(2010) Catherine Dulac   NATURE

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Histone Deacetylases 1 and 2 Form a Developmental Switch That Controls Excitatory Synapse Maturation and Function

(2009) M. W. Akhtar et al.   JOURNAL OF NEUROSCIENCE

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

(2009) R. L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON