Article
Biochemistry & Molecular Biology
Xinlu Cao, Oksana Zolnikova, Roman Maslennikov, Maria Reshetova, Elena Poluektova, Arina Bogacheva, Maria Zharkova, Vladimir Ivashkin
Summary: This study investigated the metabolic activity of gut microbiota in cirrhosis caused by different variants of fatty liver disease (alcoholic and non-alcoholic metabolic-associated). The study found that the metabolic activity of gut microbiota in cirrhosis caused by non-alcoholic metabolic-associated fatty liver disease was significantly different from that in alcoholic cirrhosis. This metabolic activity disorder may be involved in different pathogenetic pathways.
Article
Food Science & Technology
Yi Yang, Zhilei Zhou, Yufei Liu, Xibiao Xu, Yuezheng Xu, Weibiao Zhou, Shuguang Chen, Jian Mao
Summary: The consumption of fermented wine, Huangjiu, can alleviate the progression of alcoholic liver disease by regulating the intestinal barrier function and gut microbiota.
Article
Biochemistry & Molecular Biology
Qi Hui Sam, Hua Ling, Wen Shan Yew, Zhaohong Tan, Sharada Ravikumar, Matthew Wook Chang, Louis Yi Ann Chai
Summary: Short chain fatty acids (SCFA) and medium chain fatty acids (MCFA) have divergent immunomodulatory propensities, with SCFA down-attenuating pro-inflammatory response through the TLR4 pathway, while MCFA augmenting inflammation through TLR2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Haifeng Lu, Liang Chen, Xiaxia Pan, Yujun Yao, Hua Zhang, Xiaofei Zhu, Xiaobin Lou, Chunxia Zhu, Jun Wang, Lanjuan Li, Zhongwen Wu
Summary: After lactitol intervention, there was an increase in health-promoting lactic acid bacteria and a decrease in pathogens in cirrhotic patients, suggesting a positive impact on the gut microbiome. Functionally, pathways related to pathogen factors were reduced post-treatment, indicating a regulatory effect of lactitol on the gut microbiome in cirrhotic patients.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Patricia P. Bloom, Jesus M. Luevano, Kelsey J. Miller, Raymond T. Chung
Summary: This study identified several fecal bacterial species and short-chain fatty acids (SCFAs) associated with hepatic encephalopathy (HE). Many of the species inversely linked to HE were also associated with SCFA production. Patients with a history of HE had lower concentrations of SCFAs in their feces, but fecal ammonia concentrations were similar between those with and without a history of HE. Further research is needed to understand the relationship between these factors and develop targeted interventions for treating HE.
ANNALS OF HEPATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xiaolong Hu, Yuting Wei, Tianxiang Zhang, Xiaoguo Wang, Yongtao Xu, Weiwei Zhang, Yunlin Zheng
Summary: This study investigated the gut microbiome of sika deer by sampling feces or specific segments of the gastrointestinal tract. The results showed variations in microbial composition and SCFAs among different gastrointestinal sites, suggesting the significant influence of physiological characteristics on the microbial composition.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Hui-Ju Tsai, Wei-Chun Hung, Wei-Wen Hung, Yen-Jung Lee, Yo-Chia Chen, Chun-Ying Lee, Yi-Chun Tsai, Chia-Yen Dai
Summary: This study aimed to explore the association between short-chain fatty acids (SCFAs) and the severity of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2D) patients. The results showed that the circulating levels of isobutyrate and methylbutyrate were negatively correlated with NAFLD severity. This suggests that SCFAs may be related to the severity of NAFLD in T2D patients.
Article
Medicine, Research & Experimental
Junju Zou, Qin Xiang, Danni Tan, Liuyang Shi, Xiu Liu, Yongjun Wu, Rong Yu
Summary: The Chinese herbal formulation Zuogui Jiangtang Qinggan Fang (ZGJTQGF) can potentially treat type 2 diabetes mellitus (T2DM) and fatty liver disease by restoring the balance of the gut microbiome and its metabolites. This study evaluated the hepatoprotective mechanism of ZGJTQGF in T2DM with non-alcoholic fatty liver disease (NAFLD) by analyzing gut microbiota, short-chain fatty acids (SCFAs), and metabolomics. The findings suggest that ZGJTQGF improves HFD-induced hepatic steatosis by modulating the composition of the gut microbiota and its metabolites.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Babita Shashni, Yuya Tajika, Yutaka Ikeda, Yuji Nishikawa, Yukio Nagasaki
Summary: The prevalence of non-alcoholic steatohepatitis (NASH) is increasing worldwide, and cost-effective therapeutic interventions are needed. Gut microbial dysbiosis, particularly a decrease in short-chain fatty acids (SCFA)-producing microbiota, has been linked to NASH pathogenesis. This study designed SCFA-based prodrugs that self-assembled in aqueous media to improve the therapeutic efficacy of SCFAs. NanoSCFA, particularly NanoBA, showed remarkable potential in ameliorating fatty liver disease, reducing hepatic lipogenesis and fibrosis, with negligible adverse effects. Mechanistic studies revealed that NanoBA restored the nuclear expression of PPAR alpha, a transcriptional factor regulating fatty acid oxidation, reflecting the therapeutic effects of NanoBA.
Article
Biotechnology & Applied Microbiology
Shiqing Nie, Jichen Wang, Ye Deng, Zheng Ye, Yuan Ge
Summary: This study conducted a large-scale meta-analysis of the gut microbiome in Parkinson's disease (PD), revealing the changes in potential pro-inflammatory and anti-inflammatory bacteria, genes, and pathways associated with PD. It also established models based on the gut microbiome that can predict PD occurrence. The study provides further insights into the potential mechanisms of inflammation-based prediction and treatment of PD.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Food Science & Technology
Jingchi Zhang, Jiakun Fan, Hui Luo, Zhengwei Liang, Yanhui Guan, Xin Lei, Nianguo Bo, Ming Zhao
Summary: This study evaluated the protective effect of Dendrobium officinale flower ethanol extract (DOFE) on alcoholic fatty liver disease (AFLD) and investigated its mechanisms by analyzing gut microbiota and short-chain fatty acids (SCFAs). The results showed that DOFE supplementation promoted alcohol metabolism, restored hepatic antioxidant capacity, alleviated oxidative stress, reduced inflammatory factor levels, and inhibited dyslipidemia induced by alcohol intake. Moreover, DOFE supplementation increased the diversity, structure, and composition of gut microbiota, restored abnormal SCFA levels, and helped restore intestinal function. These findings suggest that improving gut microbiota composition through DOFE supplementation may be an effective therapeutic strategy for the prevention of AFLD.
Review
Cell Biology
Alexander Visekruna, Maik Luu
Summary: Research in the past decade has shown that microbiota-derived metabolites, such as short-chain fatty acids (SCFA) and secondary bile acids (BAs), play a role in inflammation and carcinogenesis. These bacterial metabolites have diverse mechanisms that regulate immunometabolism and histone deacetylase (HDAC) activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Suvimol Charoensiddhi, Michael Conlon, Pawadee Methacanon, Parinda Thayanukul, Parichat Hongsprabhas, Wei Zhang
Summary: This study investigated the potential gut health benefits of the green seaweed Ulva rigida and the red seaweed Gracilaria fisheri, as well as their polysaccharide-enriched extracts. The extracts were found to increase the production of short-chain fatty acids, stimulate the growth of beneficial bacteria, and demonstrate potential as dietary supplements for gut health.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Endocrinology & Metabolism
Lin Li, Lifen Chen, Yuanyan Yang, Junqi Wang, Li Guo, Jingjing An, Xiaoyu Ma, Wenli Lu, Yuan Xiao, Xinqiong Wang, Zhiya Dong
Summary: This study explores the potential relationship between gut microbiota, their metabolites, and idiopathic short stature disease (ISS). By comparing the gut microbiota and short-chain fatty acids (SCFAs) between children with ISS and those of normal height, the study shows that the composition of gut microbiota and the levels of its metabolites may be related to ISS pathogenesis. Specific strains with increased or decreased abundance could serve as biomarkers for diagnosing ISS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Satya Priya Sharma, Ki Tae Suk, Dong Joon Kim
Summary: The review highlights the crucial role of gut microbes in maintaining liver homeostasis and the impact of dysbiosis on the development of fatty liver disease. The changes in gut microbial composition in alcoholic and nonalcoholic fatty liver diseases and how they contribute to the pathophysiology of the disease are discussed. New approaches related to gut microbes for the diagnosis and treatment of fatty liver disease are also summarized.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Qian Xiang, Jing Xiong, Zhi Jing Zhao, Ting Zhou, Jun Wu, Xia Chen
Summary: This study investigated the effects of unsupervised walking exercise using WeChat combined with BCAA supplementation on skeletal muscle mass and strength in patients with liver cirrhosis. The results showed that this combination treatment could significantly improve muscle mass and strength, and reduce the occurrence of sarcopenia.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Article
Nanoscience & Nanotechnology
Qian Xiang, Ling Xiong, Xia Chen, Li Chen, Juan He, Ting Zhou
NANOSCIENCE AND NANOTECHNOLOGY LETTERS
(2020)