Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis

TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

(2022) Jiao Wu et al.   Nature Communications

Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy

(2022) Ting Zhao et al.   Frontiers in Immunology

TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis

(2021) Chipeng Xiao et al.   RHEUMATOLOGY

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity

(2021) Pengchong Li et al.   NATURE IMMUNOLOGY

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

(2020) Gyrid Nygaard et al.   Nature Reviews Rheumatology

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

(2020) Junmei Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rheumatoid Arthritis

(2019) Jeffrey A. Sparks   ANNALS OF INTERNAL MEDICINE

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness

(2019) David Kuo et al.   Science Translational Medicine

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis

(2018) Young-Sun Lee et al.   MOLECULAR CANCER RESEARCH

Review: The Tumor-Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine

(2018) Sungyong You et al.   Arthritis & Rheumatology

Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis

(2018) Jane Falconer et al.   Arthritis & Rheumatology

Pathogenic stromal cells as therapeutic targets in joint inflammation

(2018) Stephanie G. Dakin et al.   Nature Reviews Rheumatology

The role of semaphorins in immune responses and autoimmune rheumatic diseases

(2017) Masayuki Nishide et al.   Nature Reviews Rheumatology

Macrophage heterogeneity in the context of rheumatoid arthritis

(2016) Irina A. Udalova et al.   Nature Reviews Rheumatology

Secreted Semaphorin 5A Activates Immune Effector Cells and Is a Biomarker for Rheumatoid Arthritis

(2014) Christiane Gras et al.   Arthritis & Rheumatology

Semaphorin 5A Promotes Gastric Cancer Invasion/Metastasis via Urokinase-Type Plasminogen Activator/Phosphoinositide 3-Kinase/Protein Kinase B

(2013) Guoqing Pan et al.   DIGESTIVE DISEASES AND SCIENCES

Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Masaru Kato et al.   Arthritis & Rheumatology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Class 5 Transmembrane Semaphorins Control Selective Mammalian Retinal Lamination and Function

(2011) Ryota L. Matsuoka et al.   NEURON

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Specifically modified osteopontin in rheumatoid arthritis fibroblast-like synoviocytes supports interaction with B cells and enhances production of interleukin-6

(2009) Yasuhiro Take et al.   ARTHRITIS AND RHEUMATISM

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis

(2009) Anguraj Sadanandam et al.   MICROVASCULAR RESEARCH