期刊
VIRUSES-BASEL
卷 14, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/v14061345
关键词
COVID-19; SARS-CoV-2; repurposing; repositioning; antiviral; Molnupiravir; NHC; N4-hydroxycytidine
类别
资金
- School of Science, Monash University Malaysia (SoS Strategic Grant 2020)
- National University of Singapore
Molnupiravir is a compound with antiviral activity that can disable SARS-CoV-2 replication by inducing viral RNA mutations, thereby improving the severity of COVID-19. Further research is needed to investigate its long-term side effects, but Molnupiravir shows promise as a treatment and prophylaxis against COVID-19.
Molnupiravir is a beta-d-N4-hydroxycytidine-5 '-isopropyl ester (NHC) compound that exerts antiviral activity against various RNA viruses such as influenza, SARS, and Ebola viruses. Thus, the repurposing of Molnupiravir has gained significant attention for combatting infection with SARS-CoV-2, the etiological agent of COVID-19. Recently, Molnupiravir was granted authorization for the treatment of mild-to-moderate COVID-19 in adults. Findings from in vitro experiments, in vivo studies and clinical trials reveal that Molnupiravir is effective against SARS-CoV-2 by inducing viral RNA mutagenesis, thereby giving rise to mutated complementary RNA strands that generate non-functional viruses. To date, the data collectively suggest that Molnupiravir possesses promising antiviral activity as well as favorable prophylactic efficacy, attributed to its effective mutagenic property of disrupting viral replication. This review discusses the mechanisms of action of Molnupiravir and highlights its clinical utility by disabling SARS-CoV-2 replication, thereby ameliorating COVID-19 severity. Despite relatively few short-term adverse effects thus far, further detailed clinical studies and long-term pharmacovigilance are needed in view of its mutagenic effects.
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