Article
Endocrinology & Metabolism
Linfeng Mao, Chunmei Zheng, Shengzhao Ou, Youwu He, Chuanjie Liao, Ganlu Deng
Summary: This study analyzed the impact of Hashimoto's thyroiditis (HT) on the diagnosis and treatment of thyroid nodules and investigated the relationship between HT and thyroid cancer (TC). The results suggested that HT is associated with an increased risk of TC development but may be protective against the progression and metastasis of papillary thyroid carcinoma (PTC). The coexistence of HT also affects the evaluation of thyroid nodules by ultrasound.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Nicole Lafontaine, Scott G. Wilson, John P. Walsh
Summary: This review summarizes the current understanding of DNA methylation (DNAm) in autoimmune thyroid disease (AITD), highlighting differential DNAm in several genes implicated in AITD. However, further replication and functional studies are needed to support the causal roles of these differential DNAm in AITD pathogenesis. Additionally, the influence of thyroid hormones on DNAm and the confounding effects of reverse causation need to be considered. Recent studies suggest a potential mechanism for the association between iodine and AITD through differential DNAm patterns in candidate genes. The research focus is shifting towards epigenome-wide studies to elucidate the role of DNAm in AITD and identify diagnostic, prognostic, and therapeutic targets.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cell Biology
Jessica Castro de Vasconcelos, Icleia Barreto de Siqueira, Frederico Fernandes Ribeiro Maia, Maria Candida Ribeiro Parisi, Denise Engelbrecht Zantut-Wittmann
Summary: In Hashimoto's thyroiditis, lymphocytic infiltrate shows predominance of anti-apoptosis except for BID, while thyrocytes exhibit a balance between pro-apoptosis and anti-apoptosis, with cell proliferation similar to normal thyroid. The expression of BID gene in HT lymphocytes suggests the influence of thyroid hormone on increasing lymphocytic apoptosis rates.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Dania Akeil Abed Alkader, Naweedullah Asadi, Uzma Solangi, Ransherjit Singh, Sayed Farhad Rasuli, Muhammad Jawad Farooq, F. N. U. Raheela, Radeyah Waseem, Syed Mujahid Gilani, Kiran Abbas, Moiz Ahmed, Desmond Boakye Tanoh, Hussain Haider Shah, Ayusha Dulal, Muhammad Sheheryar Hussain, Abdul Subhan Talpur
Summary: There is a significant difference in the diversity and composition of the gut microbiota in patients with autoimmune thyroid diseases (AITDs).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Rui Zhao, Wei Zhang, Chenghong Ma, Yaping Zhao, Rong Xiong, Hanmin Wang, Weiwen Chen, Song Guo Zheng
Summary: Vitamin D is essential for human health, playing a critical role in calcium and phosphorus metabolism, bone health, and the immune system. Research has shown a close connection between vitamin D deficiency and autoimmune thyroid diseases, highlighting the importance of understanding its mechanisms and implications for intervention and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yiqing Hou, Chao Chen, Lu Zhang, Wei Zhou, Qinyang Lu, Xiaohong Jia, Jingwen Zhang, Cen Guo, Yuxiang Qin, Lifeng Zhu, Ming Zuo, Jing Xiao, Lingyun Huang, Weiwei Zhan
Summary: This study successfully developed an efficient method for diagnosing thyroid nodules using a Deep Neural Network model, demonstrating good performance under various parenchymal conditions and especially showing superior performance in patients with Hashimoto's Thyroiditis compared to radiologists with different years of experience.
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Venera Berisha-Muharremi, Bernard Tahirbegolli, Ruth Phypers, Reem Hanna
Summary: This study compared the efficacy of photobiomodulation therapy (PBM) with supplements in restoring thyroid function and anthropometric parameters in patients with Hashimoto thyroiditis (HT). The results showed that the combination of PBM and supplements had a significant improvement in the mentioned aspects compared to supplements alone.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Barbara Swiechowicz, Anna Kasielska-Trojan, John T. Manning, Boguslaw Antoszewski
Summary: Hashimoto thyroiditis and Graves' disease are autoimmune thyroid diseases that occur more frequently in women. The 2D:4D digit ratio may be associated with prenatal estrogen and testosterone levels. In women, higher 2D:4D is found in those with Hashimoto thyroiditis, while lower 2D:4D is found in those with Graves' disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Qiuxian Li, Wanyu Yang, Jiashu Li, Zhongyan Shan
Summary: This bibliometric analysis provides an overview of the current research status in the field of autoimmune thyroiditis (AIT) and reveals the dynamic developments and hotspots. The study found that researchers have primarily focused on areas such as apoptosis, insulin resistance, encephalopathy, and IFN-gamma related to AIT in the past 20 years. However, with the emergence of new directions such as papillary thyroid cancer, Vitamin D, oxidative stress, polymorphism, and association, researchers are now more interested in exploring the relationship between papillary thyroid carcinoma and AIT, the impact of vitamin D supplementation on AIT, the role of oxidative stress in thyroid disease, and the influence of polymorphism.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Agata Czarnywojtek, Ewa Florek, Krzysztof Pietronczyk, Nadia Sawicka-Gutaj, Marek Ruchala, Ohad Ronen, Iain J. Nixon, Ashok R. Shaha, Juan Pablo Rodrigo, Ralph Patrick Tufano, Mark Zafereo, Gregory William Randolph, Alfio Ferlito
Summary: Vitamin D deficiency has received significant attention in medical research due to its role in regulating calcium-phosphorus metabolism and its potential impact on the immune system. Studies have shown that Vitamin D deficiency can affect autoimmune diseases, coeliac disease, infections, and cancer. Recent research has also highlighted its significant role in autoimmune thyroid diseases such as Hashimoto thyroiditis, Graves' disease, and postpartum thyroiditis. This review summarizes the current state of knowledge on the role of Vitamin D in autoimmune thyroid diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Yu-tian Cao, Kai-yu Zhang, Jing Sun, Yan Lou, Tian-su Lv, Xinyi Yang, Wen-hui Zhang, Jiang-yi Yu, Qi-biao Wu, Xi-qiao Zhou
Summary: Platelet index abnormalities are present in patients with autoimmune thyroid disease (AITD), with increased platelet count (PLT) and mean platelet volume (MPV) in AITD patients compared to healthy controls. However, no significant difference was found in platelet distribution width (PDW). The differences in PLT were mainly observed in Hashimoto's thyroiditis (HT) and hypothyroid groups, while the differences in MPV were mainly observed in Graves' disease (GD) and hyperthyroid groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bing Wang, Zheng Wan, Mingbo Zhang, Fengxia Gong, Linlin Zhang, Yukun Luo, Jing Yao, Chen Li, Wen Tian
Summary: This study investigated the diagnostic value of a dynamic AI ultrasound intelligent assistant system for thyroid nodules in patients with Hashimoto's thyroiditis (HT). The results showed that dynamic AI had high accuracy, specificity, and sensitivity in differentiating between benign and malignant nodules, and it outperformed preoperative ultrasound and fine needle aspiration cytology (FNAC) in HT patients.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Endocrinology & Metabolism
Boshen Gong, Chuyuan Wang, Fanrui Meng, Haoyu Wang, Bo Song, Yang Yang, Zhongyan Shan
Summary: Autoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Recent studies have shown altered gut microbiota composition in patients with AITD, with changes in alpha diversity and abundance of specific gut microbiota. The meta-analysis indicated an association between AITD and alteration of microbiota composition at the family, genus, and species levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Sport Sciences
Jeannette A. C. Lankhaar, Ellen Kemler, Hedwig Hofstetter, Dorine C. M. Collard, Pierre M. J. Zelissen, Janine H. Stubbe, Frank J. G. Backx
Summary: This study aimed to compare physical activity and sports participation in patients with hypothyroidism on thyroid hormone replacement therapy with control subjects. The findings showed that patients were less likely to comply with moderate-intensity physical activity guideline, but were more active in sports participation compared to controls.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Endocrinology & Metabolism
Agnieszka Adamska, Anna Poplawska-Kita, Katarzyna Siewko, Agnieszka Lebkowska, Anna Krentowska, Angelika Buczynska, Lukasz Poplawski, Piotr Szumowski, Malgorzata Szelachowska, Adam Jacek Kretowski, Irina Kowalska
Summary: Women with Hashimoto thyroiditis have lower levels of AMH and this is associated with higher body fat mass, regardless of serum leptin levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Christine E. Cherella, Danielle M. Richman, Enju Liu, Mary C. Frates, Biren P. Modi, Benjamin Zendejas, Jessica R. Smith, Justine A. Barletta, Monica L. Hollowell, Ari J. Wassner
Summary: In children with differentiated thyroid cancer, tumor multifocality in the primary lobe is associated with bilateral disease, while clinically node-negative children with unifocal tumors in the primary lobe have a low likelihood of contralateral disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pediatrics
Gregory Keefe, Katherine Culbreath, Jamie Knell, Priyanka Chugh, Steven J. Staffa, Tom Jaksic, Biren P. Modi
Summary: Hepatoprotective parenteral nutrition (PN) has a protective effect on liver function in children with intestinal failure (IF), but long-term PN dependence is associated with persistent elevation of transaminases in the majority of patients.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Oncology
Christine E. Cherella, Monica L. Hollowell, Jessica R. Smith, Benjamin Zendejas, Biren P. Modi, Edmund S. Cibas, Ari J. Wassner
Summary: Nuclear atypia in pediatric AUS nodules is associated with a high rate of malignancy, while architectural atypia is not. Repeat FNA may inform clinical decisions for nodules with nuclear atypia. Nodules without nuclear atypia and without suspicious clinical features can be considered for observation rather than resection or repeat FNA.
CANCER CYTOPATHOLOGY
(2022)
Article
Pediatrics
Gregory Keefe, Katherine Culbreath, Erika M. Edwards, Kate A. Morrow, Roger F. Soll, Biren P. Modi, Jeffrey D. Horbar, Tom Jaksic
Summary: This study aims to investigate the mortality rates and hospital lengths of stay in neonates with esophageal atresia and tracheoesophageal fistula, and how birth weight and associated congenital anomalies affect these outcomes. The study found that lower birth weight and the presence of concomitant congenital anomalies were associated with increased mortality rates and prolonged hospital lengths of stay.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Katherine Culbreath, Gregory Keefe, Steven J. Staffa, Nicole Wynne, Frances Grimstad, Lissette Jimenez, Tom Jaksic, Biren P. Modi
Summary: Pediatric intestinal failure (PIF) does not delay or impair puberty, but there is a high incidence of short stature, highlighting the importance of optimizing prepubertal growth.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Katherine Culbreath, Gregory Keefe, Erika M. Edwards, Kate A. Morrow, Roger F. Soll, Tom Jaksic, Jeffrey D. Horbar, Biren P. Modi
Summary: This study compared the morbidities between spontaneous intestinal perforation (SIP) and necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants. The results showed that both SIP and NEC had similar lengths of stay in the hospital, which were significantly longer than those without SIP or NEC. The risk of growth morbidity at discharge was similar between SIP and NEC, but higher than infants without SIP or NEC. Infants with NEC were less likely to require supplemental oxygen at discharge compared to infants with SIP.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Katherine Culbreath, Gregory Keefe, Emily Nes, Jamie Knell, Sam M. Han, Priyanka Chugh, Grace Y. Han, Alexandra N. Carey, Lissette Jimenez, Jay R. Thiagarajah, Sung-Yun Pai, Biren P. Modi, Tom Jaksic
Summary: This study describes the characteristics and clinical course of six patients with intestinal failure who were found to have biallelic TTC7A mutations, highlighting key management strategies for identifying these patients and improving their survival. The high incidence of pyloric atresia in this case series suggests that the presence of pyloric atresia, especially in the setting of other intestinal disorders, should prompt screening for CID and a genetic evaluation. Recognition of the mutation and involvement of appropriate interdisciplinary care teams are essential for optimizing survival of these complex patients.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2022)
Article
Obstetrics & Gynecology
Katherine Culbreath, Jamie Knell, Gregory Keefe, Emily Nes, Sam M. Han, Erika M. Edwards, Kate A. Morrow, Roger F. Soll, Tom Jaksic, Jeffrey D. Horbar, Biren P. Modi
Summary: This study evaluated the impact of necrotizing enterocolitis on mortality in low birth weight infants with intraventricular hemorrhage. The results showed that both medical and surgical NEC increased the risk of mortality, but the severity of IVH modified this effect.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Gregory Keefe, Katherine Culbreath, Steven J. Staffa, Alexandra N. Carey, Tom Jaksic, Riten Kumar, Biren P. Modi
Summary: The rate of venous thromboembolism (VTE) was quantified in pediatric patients with severe intestinal failure, and associated risk factors were identified. The study found that the cumulative incidence of VTE in these patients was 28.1%, and the number of catheters and early gestational age were independent risk factors for VTE.
JOURNAL OF PEDIATRICS
(2023)