Article
Agriculture, Dairy & Animal Science
Verena Habermaass, Daniela Olivero, Eleonora Gori, Chiara Mariti, Erika Longhi, Veronica Marchetti
Summary: This study evaluated the gut microbiota (GM) in dogs diagnosed with chronic hepatobiliary disease (CHD), particularly cholestatic CHD. The findings suggest that cholestasis is associated with alterations in the gut microbiota, with certain bacterial taxa being decreased and others increased. Clinicians should be aware of the gut-liver interaction leading to dysbiosis in dogs with CHD.
Article
Food Science & Technology
Moon Ho Do, Hyun Hee L. Lee, Yoonsook Kim, Hye-Bin Lee, Eunjung Lee, Jae Ho Park, Ho-Young Park
Summary: This study suggests that water-soluble extract from molokhia (WM) can alleviate alcohol-induced liver damage by improving gut microbial composition and gut barrier function.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Angel Yun-Kuan Thye, Yi-Rou Bah, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Ya-Wen He, Sunny-Hei Wong, Sivakumar Thurairajasingam, Kok-Gan Chan, Learn-Han Lee, Vengadesh Letchumanan
Summary: Evidence suggests that the gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health, regulated through mechanisms such as inflammatory mediators and the immune system. Microbiota dysregulation has been observed in various inflammatory skin conditions, such as atopic dermatitis, rosacea, and psoriasis. Understanding the involvement of the gut microbiome in regulating skin health could lead to the development of novel therapies for these skin disorders, particularly psoriasis.
Article
Food Science & Technology
Hailong Li, Ziyang Xie, Yao Zhang, Yue Liu, Aijing Niu, Yingying Liu, Linbo Zhang, Lili Guan
Summary: The study found that polysaccharide from Rosa rugosa (RRP) has a significant protective effect on acute alcoholic liver disease (ALD), by regulating liver function and balancing gut microbiota, providing theoretical basis for the development of natural liver-protecting drugs.
Article
Biochemistry & Molecular Biology
Tongtong Liu, Haitao Yu, Zeming Zhang, Yunfei Xie, Long Yang, Fuping You
Summary: Intestinal ELF4 plays a critical role in maintaining gut barrier and homeostasis, and is beneficial in alleviating alcohol-induced hepatic steatosis and injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Takashi Kobayashi, Michihiro Iwaki, Atsushi Nakajima, Asako Nogami, Masato Yoneda
Summary: Global lifestyle changes have led to an increased incidence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). High-fat and high-fructose diets increase intestinal permeability, exposing the liver to endotoxins. The intestinal axis, including dysbiosis of the gut microbiome and leaky-gut syndrome, is linked to these liver diseases. This review summarizes recent research on the gut microbiome and liver diseases, providing new research directions for understanding the mechanisms and developing novel treatment targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Leonardo Cesar de Freitas Cayres, Larissa Vedovato Vilela de Salis, Guilherme Siqueira Pardo Rodrigues, Andre van Helvoort Lengert, Ana Paula Custodio Biondi, Larissa Donadel Barreto Sargentini, Joao Luiz Brisotti, Eleni Gomes, Gislane Lelis Vilela de Oliveira
Summary: Hashimoto's thyroiditis is the most common autoimmune disease globally, characterized by chronic inflammation and autoantibodies against thyroid peroxidase and thyroglobulin. Alterations in gut microbiota, including an increase in Bacteroides species and a decrease in Bifidobacterium, were observed in Brazilian patients with HT. The study also found significant differences in dietary habits between patients and the control group, with an inverse correlation between animal-derived protein intake and Bacteroides genus in patients with HT.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zizhao Yang, Fei Wei, Bin Zhang, Yun Luo, Xiaoyan Xing, Min Wang, Rongchang Chen, Guibo Sun, Xiaobo Sun
Summary: The brain-gut axis plays a crucial role in the development of ischemic stroke, and it is involved in the transduction of immune molecules. Hypoxia-ischemia can lead to various gut complications and negatively impact the brain's immune system. This review summarizes recent studies on immune signal exchange and discusses the effects of gut complications on immune signal transduction in the brain.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Nadia Marascio, Carmen De Caro, Angela Quirino, Maria Mazzitelli, Emilio Russo, Carlo Torti, Giovanni Matera
Summary: Hepatitis C virus remains a significant global healthcare issue, but direct-acting antiviral drugs have improved treatment outcomes. Liver damage affects the gut microbiota, and drug therapy can restore the balance, improving liver disease progression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Liang Zhao, Shaoxuan Wang, Nanhai Zhang, Jingxuan Zhou, Arshad Mehmood, Rifat Nowshin Raka, Feng Zhou, Lei Zhao
Summary: Alcoholic liver disease is a major global health issue associated with various severe liver diseases. Alcohol consumption can disturb the composition of gut microbiota, affecting the treatment of ALD. Plant natural products and polyphenolic compounds have beneficial effects on ALD-related disorders and may act through modulating the gut-liver axis.
Article
Gastroenterology & Hepatology
Thomas Henry Tranah, Lindsey A. Edwards, Bernd Schnabl, Debbie Lindsay Shawcross
Summary: Cirrhotic portal hypertension is characterized by the development of serious complications such as ascites, encephalopathy, bleeding, and hepatorenal syndrome, which are often caused by cirrhosis-associated immune dysfunction. Bacterial infections are common complications of chronic liver disease and are closely linked to dysbiosis of the intestinal microbiota.
Article
Multidisciplinary Sciences
Cameron Martino, Livia S. Zaramela, Bei Gao, Mallory Embree, Janna Tarasova, Seth J. Parker, Yanhan Wang, Huikuan Chu, Peng Chen, Kuei-Chuan Lee, Daniela Domingos Galzerani, Jivani M. Gengatharan, Asama Lekbua, Maxwell Neal, Rob Knight, Hidekazu Tsukamoto, Christian M. Metallo, Bernd Schnabl, Karsten Zengler
Summary: Liver damage due to chronic alcohol use is a common liver disease. This study investigated the metabolic impacts of alcohol consumption on the gut microbiota using isotope-labeled ethanol, metagenomics, and metatranscriptomics. The results showed that ethanol is not directly metabolized by the gut microbiota, but changes in the microbiota are a side effect of elevated acetate levels. Understanding these changes is important for understanding alcohol-related liver disease.
NATURE COMMUNICATIONS
(2022)
Article
Infectious Diseases
Dan Zhou, Qiu Wang, Hanmin Liu
Summary: The gut-lung axis may play a role in SARS-CoV-2 infection and the development of COVID-19, influencing disease severity through regulating microbiota, microbiota metabolites, common mucosal immunity, and ACE2 pathways.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Jang Han Jung, Sung-Eun Kim, Ki Tae Suk, Dong Joon Kim
Summary: Alcoholic liver disease (ALD) encompasses a range of diseases that can have serious consequences if left untreated. Alcohol consumption alters the composition of the gut microbiota, exacerbating hepatic inflammation and fibrosis. These changes weaken the gut barrier and impact host immunity and metabolism. Studies have shown promising results using probiotics, prebiotics, antibiotics, and fecal microbial transplantation for the treatment of ALD. However, further clinical research is needed to evaluate their efficacy.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Roberta Forlano, Benjamin H. Mullish, Lauren A. Roberts, Mark R. Thursz, Pinelopi Manousou
Summary: Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of liver disease worldwide, mirroring the epidemics of obesity and metabolic syndrome. There is an increasing body of evidence showing a crucial role of the crosstalk between the gut and the liver in the development and progression of NAFLD. Gut permeability is an important factor associated with the development of NAFLD, type-2 diabetes, and obesity, and may be a potential therapeutic target for NAFLD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Byoungjin Park, Dong-Hyuk Jung, Yong-Jae Lee
Summary: HDL cholesterol has a role in lipid metabolism and also functions in suppressing blood oxidation reactions and protecting vascular endothelial cells. The uric acid/HDL cholesterol ratio (UHR) has been identified as a new biomarker for evaluating the interactions between inflammatory and anti-inflammatory substances in the blood. The study found a positive association between high UHR values and incident ischemic heart disease (IHD), suggesting that UHR could be a useful measure for assessing cardiovascular risk in the preclinical stage.
Article
Biochemistry & Molecular Biology
Sung-Bum Lee, Ja-Eun Choi, Byoungjin Park, Mi-Yeon Cha, Kyung-Won Hong, Dong-Hyuk Jung
Summary: This study investigated the interactions of genetic variants and nutrient intake on cardiovascular disease, revealing that specific polymorphisms associated with dyslipidaemia and nutrients intake can influence cardio-cerebrovascular disease risk. The findings suggest the importance of genetic factors in dietary guidelines for the prevention and management of cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
In-Ho Seo, Hye Sun Lee, Yong-Jae Lee
Summary: This study aimed to evaluate the association between fatty liver index (FLI) and incident type 2 diabetes (T2DM) and determine whether FLI could be used as an indicator of T2DM. Analysis of a Korean cohort study data revealed that baseline FLI grade could be a future indicator of T2DM even when prior insulin levels were normal.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seungah Song, Da-Hye Son, Su-Jung Baik, Wan-Je Cho, Yong-Jae Lee
Summary: This study aimed to compare the usefulness of modified TyG indices for predicting NAFLD with the TyG index and FLI. The results showed that TyG-WC is a reliable indicator for the presence of NAFLD in Korean adults.
Review
Biochemistry & Molecular Biology
In-Ho Seo, Yong-Jae Lee
Summary: Complete blood count is a commonly requested blood test that evaluates the characteristics and total numbers of cell components in the blood. Recent investigations have shown that the components of complete blood count can be used to predict the risk of cardiovascular disease and metabolic disorders.
Article
Endocrinology & Metabolism
Seung Ho Yang, Jihyun Yoon, Yong-Jae Lee, Byoungjin Park, Dong-Hyuk Jung
Summary: This study assessed the longitudinal association between LAP index and incident type 2 diabetes among non-obese Korean adults and found that a high LAP index can be an additional indicator for new-onset T2DM among middle-aged and elderly non-obese Koreans.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Da-Hye Son, Hye Sun Lee, So-Young Seol, Yong-Jae Lee, Jun-Hyuk Lee
Summary: Oxidative stress is a new risk factor for chronic kidney disease (CKD). The study aimed to verify the relationship between the overall oxidative balance represented by the oxidative balance score (OBS) and the incidence of CKD. Data from 5795 participants without CKD were analyzed, and a dose-response association between the OBS and incident CKD was found in both men and women. The results suggest that a healthy diet and lifestyle that increase the OBS may help prevent CKD in both genders.
Article
Health Care Sciences & Services
Yumin Sung, Yong-Jae Lee, Dong-Hyuk Jung, Byoungjin Park
Summary: Isolated elevation of gamma-glutamyltransferase (GGT) may be an additional measure for assessing and managing future ischemic heart disease (IHD) risks among lean Koreans without diabetes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Jiwon Kwak, In-Ho Seo, Yong-Jae Lee
Summary: In this study, we examined the relationship between serum GGT levels and the risk of developing MetS. Higher GGT levels were associated with an increased risk of MetS, and this association was stronger in men compared to women.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Nutrition & Dietetics
Jihyun Yoon, Byoungjin Park, Heejung Kim, Seungjun Choi, Donghyuk Jung
Summary: This study aimed to examine the effect of Korean Red Ginseng (KRG) on virus-specific antibodies after COVID-19 vaccination. The results showed that the antibody formation rate of the KRG group was sustained higher than that of the control group for 12 weeks after the second dose, especially in those above 50 years old. It suggests that KRG can enhance and maintain vaccine immune response.
Article
Biochemistry & Molecular Biology
Sung-Bum Lee, Hui-Jeong Lee, Ha Eun Ryu, Byoungjin Park, Dong-Hyuk Jung
Summary: Multiple studies have shown that hyperuricemia is associated with the development of ischemic heart disease (IHD). Additionally, there is growing evidence suggesting that hyperuricemia may contribute to the progression of IHD as a pathogenic factor. Ironically, uric acid can also act as an antioxidant, as demonstrated in experimental studies. The aim of this study was to analyze the association between uric acid and IHD in patients with early-stage chronic kidney disease (CKD).
Article
Nutrition & Dietetics
Ji Won Kwak, Yong Jae Lee, Byoungjin Park, Dong Hyuk Jung
Summary: This study investigated the risk of ischemic heart disease (IHD) in individuals with elevated CEA levels, hepatic steatosis, and their co-occurrence. The results showed that the co-occurrence of elevated CEA levels and hepatic steatosis increases the risk of IHD.
FRONTIERS IN NUTRITION
(2023)
