Article
Medicine, General & Internal
Brian Yu, Sung Jun Ma, Olivia Waldman, Cynthia Dunne-Jaffe, Udit Chatterjee, Lauren Turecki, Jasmin Gill, Keerti Yendamuri, Austin Iovoli, Mark Farrugia, Anurag K. Singh
Summary: This retrospective cohort study found that the use of intensity-modulated radiation therapy (IMRT) for postoperative radiation therapy (PORT) among patients with incompletely resected non-small cell lung cancer (NSCLC) increased in the US from 2004 to 2019. Furthermore, IMRT was associated with improved survival compared with 3D conformal radiation therapy (3DCRT).
Article
Health Care Sciences & Services
Dorota Maria Borowicz, Konstantin N. Shipulin, Gennady V. Mytsin, Agnieszka Skrobala, Piotr Milecki, Victor N. Gayevsky
Summary: Comparison between passive scattering (PS) and intensity-modulated proton therapy (IMPT) for ultra-hypofractionated proton therapy in localized prostate cancer (PCa) showed that IMPT provided better target coverage and lower mean doses to the rectum and bladder compared to PS. However, PS had a slightly better performance in high dose distribution to the rectum. There were no significant differences in mean conformity index values and gamma index between the two treatment methods.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Jianzhong Cao, Xiaodong Zhang, Bo Jiang, Jiayun Chen, Xiaochun Wang, Li Wang, Narayan Sahoo, X. Ronald Zhu, Rong Ye, Pierre Blanchard, Adam S. Garden, C. David Fuller, G. Brandon Gunn, Steven J. Frank
Summary: The study showed that in patients with oropharyngeal cancer, IMPT treatment was associated with less late xerostomia compared to IMRT treatment. Dosimetric variables related to the oral cavity were associated with late xerostomia.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Fady Samir, Talaat M. Meaz, Fathi AEl Hussiny, Ahmed A. Ahmed, Amr A. Mahmoud, Tamer Refaat, Ahmed Gawish, Mohamed Abouegylah
Summary: The study compared four techniques in prostate treatment to find the preferred technique. Plans were created for 30 prostate cancer patients using different techniques, and the quality of the plans was assessed by comparing target coverage, organs at risk, monitor units, homogeneity, and conformity among the techniques.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Engineering, Biomedical
Jiayuan Peng, Yuanhua Chen, Jun Zhao, Jiazhou Wang, Xiang Xia, Bin Cai, Thomas R. Mazur, Ji Zhu, Zhen Zhang, Weigang Hu
Summary: The study developed an efficient and automatic approach, AGAP, that fully automated the IMRT planning process in rectal cancer radiotherapy. It reduced the dependence on planner experience and maintained comparable plan quality with P-auto plans.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Oncology
Laila Koenig, Cornelia Jaekel, Nikolaus von Knebel Doeberitz, Meinhard Kieser, Fabian Eberle, Marc Muenter, Juergen Debus, Klaus Herfarth
Summary: The GRIPS trial aims to assess whether proton beam radiotherapy can reduce toxicity for glioblastoma patients during and in the first months after treatment.
RADIATION ONCOLOGY
(2021)
Article
Oncology
William T. Hrinivich, Heng Li, Anh Tran, Sahaja Acharya, Matthew M. Ladra, Khadija Sheikh
Summary: Intensity modulated proton therapy provides excellent normal tissue sparing for pediatric cancer treatment, but requires range shifter devices for shallow targets and small anatomy, which increases lateral scatter. This study presents the design, manufacturing, and characterization of a range shifter board that improves normal tissue sparing while minimizing lateral scatter, and compares it to standard range shifter planning approaches. Dosimetric measurements were performed to evaluate the device, and treatment plans from two pediatric patients were compared, showing significant reduction in lung and kidney dose compared to standard range shifter. This device is now in routine use at the clinic.
Article
Oncology
Michelle Oud, Sebastiaan Breedveld, Marta Gizynska, Michiel Kroesen, Stefan Hutschemaekers, Steven Habraken, Steven Petit, Zoltan Perko, Ben Heijmen, Mischa Hoogeman
Summary: This study proposes and evaluates a new approach in intensity modulated proton therapy, which involves the daily selection of plans from patient-specific pre-treatment established plan libraries for treatment. Compared to daily online re-planning, this approach is simpler and reduces the risk of xerostomia and dysphagia, while improving adherence to target coverage constraints.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Arthur Lalonde, Mislav Bobic, Brian Winey, Joost Verburg, Gregory C. Sharp, Harald Paganetti
Summary: This study compared the impact of setup variations and anatomical changes on the quality of head and neck IMPT treatments. The results showed that daily online-adapted plans can achieve superior target coverage and lower dose to organs at risk compared to robust optimization methods.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
Summary: In treating oropharynx cancer patients, the combination of IMRT and IMPT achieved more favorable acute toxicity profiles compared to IMRT alone, while maintaining comparable oncologic outcomes.
Article
Oncology
Darren M. Zuro, Gabriel Vidal, James Nathan Cantrell, Yong Chen, Chunhui Han, Christina Henson, Salahuddin Ahmad, Susanta Hui, Imad Ali
Summary: The purpose of this study is to investigate the treatment planning of TMI using IMPT. The dosimetric parameters of IMPT plans were evaluated and compared with VMAT plans. The results showed significant reduction in organ-at-risk dose in IMPT plans compared to VMAT plans.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Sabah Falek, Rajesh Regmi, Joel Herault, Melanie Dore, Anthony Vela, Pauline Dutheil, Cyril Moignier, Pierre-Yves Marcy, Julien Drouet, Arnaud Beddok, Noah E. Letwin, Joel Epstein, Upendra Parvathaneni, Juliette Thariat
Summary: Metallic restorations may have a more severe impact on the quality of proton therapy compared to photon radiotherapy. Multidisciplinary assessment is required before proton therapy to evaluate metal-induced errors and make decisions regarding the conservation/removal of dental metals and the optimal radiotherapy approach.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Otorhinolaryngology
Elizabeth B. Jeans, Satomi Shiraishi, Gohar Manzar, Lindsay K. Morris, Adam Amundson, Lisa A. McGee, Jean-Claude Rwigema, Michelle Neben-Wittich, David M. Routman, Daniel J. Ma, Samir H. Patel, Robert L. Foote, Scott C. Lester
Summary: IMPT is associated with decreased dose to OARs and less patient-reported acute deterioration in multiple head and neck domains. Physician-reported toxicities demonstrated less oral pain. Strong consideration for IMPT in ipsilateral head and neck patients with cancer is warranted.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Endocrinology & Metabolism
Xin Lian, Zhuoran Xu, Shuai Sun, Weiping Wang, Huijuan Zhu, Lin Lu, Xiaorong Hou, Fuquan Zhang
Summary: The study aimed to investigate the efficacy and toxicity of intensity-modulated radiotherapy (IMRT) in treating Cushing's Disease (CD). The results showed that IMRT was a highly effective therapy with low side effects for CD patients, with comparable rates of endocrine remission, tumor control, and recurrence to previous reports.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Shouliang Ding, Yongbao Li, Hongdong Liu, Rui Li, Bin Wang, Jun Zhang, Yan Chen, Xiaoyan Huang
Summary: This study evaluated the dosimetric qualities and usability of 1.5 T MR-Linac based intensity modulated radiotherapy (MRL-IMRT) compared to conventional linac IMRT plans for different clinical sites. Results showed that MRL-IMRT plans were clinically equivalent but had higher skin dose and shorter optimization time. Minor differences in plan quality between MR-Linac plans and current clinical practice were found due to machine characteristics, which should be considered in clinical practice.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Review
Oncology
Tiuri E. Kroese, Peter S. N. van Rossum, Magnus Nilsson, Florian Lordick, Elizabeth C. Smyth, Riccardo Rosati, Philippe Nafteux, Domenico D'Ugo, M. Asif Chaudry, Wojciech Polkowkski, Franco Roviello, Ines Gockel, Piotr Kolodziejczyk, Karin Haustermans, Matthias Guckenberger, Marianne Nordsmark, Maria A. Hawkins, Andres Cervantes, Tania Fleitas, Eric van Cutsem, Markus Moehler, Anna D. Wagner, Hanneke W. M. van Laarhoven, Richard van Hillegersberg
Summary: Currently, there is a lack of uniform definition and treatment for oligometastatic esophagogastric cancer. The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to develop a multidisciplinary European consensus statement to improve outcomes for these patients.
Editorial Material
Oncology
Birgitte Vrou Offersen, Marianne C. Aznar, Carol Bacchus, Rob P. Coppes, Eric Deutsch, Dieter Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Anne W. M. Lee, Steffen Loeck, David I. Thwaites, Albert J. van der Kogel, Uulke van der Heide, Vincenzo Valentini, Jens Overgaard, Michael Baumann
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Paige A. Taylor, Elizabeth Miles, Lone Hoffmann, Sarah M. Kelly, Stephen F. Kry, Ditte Sloth Moller, Hugo Palmans, Kamal Akbarov, Marianne C. Aznar, Enrico Clementel, Coreen Corning, Rachel Effeney, Brendan Healy, Alisha Moore, Mitsuhiro Nakamura, Samir Patel, Maddison Shaw, Markus Stock, Joerg Lehmann, Catharine H. Clark
Summary: The Global Clinical Trials RTQA Harmonization Group (GHG) conducted a study to evaluate and prioritize clinical trial quality assurance, and identified high-risk errors in quality assurance tests for proton and photon therapy clinical trials. These findings can be used to improve the quality of radiotherapy and optimize clinical trial processes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Lien Smets, Annelies Debucquoy, Eva Oldenburger, Chantal Van Audenhove, Lynn Debrun, Jeroen Dekervel, Gabriele Bislenghi, Andre D'Hoore, Albert Wolthuis, Karin Haustermans
Summary: This study developed a patient decision aid (PtDA) for rectal cancer patients with a clinical complete response after neo-adjuvant treatment, aiming to facilitate shared decision making. The results of the survey showed that most patients believed using a PtDA in clinical practice would be of added value in decision making.
Review
Cardiac & Cardiovascular Systems
Melanie Grehn, Stefano Mandija, Marcin Miszczyk, David Krug, Bartlomiej Tomasik, Kristine E. Stickney, Pino Alcantara, Filippo Alongi, Matteo Anselmino, Ricardo Salgado Aranda, Brian Balgobind, Judit Boda-Heggemann, Leif-Hendrik Boldt, Nicola Bottoni, Jakub Cvek, Olgun Elicin, Gaetano Maria De Ferrari, Rutger J. Hassink, Colien Hazelaar, Gerhard Hindricks, Coen Hurkmans, Cinzia Iotti, Tomasz Jadczyk, Otakar Jiravsky, Raphaël Jumeau, Steen Buus Kristiansen, Mario Levis, Manuel Algara Lopez, Julio Marti-Almor, Felix Mehrhof, Ditte Sloth Moller, Giulio Molon, Alexandre Ouss, Petr Peichl, Jiri Plasek, Pieter G. Postema, Aurelio Quesada, Tobias Reichlin, Roberto Rordorf, Boris Rudic, Ardan M. Saguner, Rachel M. A. ter Bekke, Jose Lopez Torrecilla, Esther G. C. Troost, Viviana Vitolo, Nicolaus Andratschke, Katja Zeppenfeld, Slawomir Blamek, Martin Fast, Ludovica de Panfilis, Oliver Blanck, Etienne Pruvot, Joost J. C. Verhoeff
Summary: The STOPSTORM consortium, funded by the EU Horizon 2020 Framework, aims to establish a standardized treatment and outcome platform for investigating STAR in ventricular tachycardia. The consortium consists of 31 clinical and research institutions and is divided into nine work packages. A comprehensive questionnaire was conducted to review the current clinical practice of STAR in Europe, highlighting potential areas of optimization and harmonization.
Article
Oncology
Tiuri E. Kroese, Hanneke W. M. van Laarhoven, Sebastian F. Schoppman, Pieter R. A. J. Deseyne, Eric van Cutsem., Karin Haustermans., Philippe. Nafteux, Melissa Thomas, Radka Obermannova, Hanna R. Mortensen, Marianne Nordsmark, Per Pfeiffer, Anneli Elme, Antoine Adenis, Guillaume Piessen, Christiane J. Bruns, Florian Lordick, Ines Gockel, Markus Moehler, Cihan Gani, Theodore Liakakos, John Reynolds, Alessio G. Morganti, Riccardo Rosati, Carlo Castoro, Francesco Cellini, Domenico D'Ugo, Franco Roviello, Maria Bencivenga, Giovanni de Manzoni, Mark I. van Berge Henegouwen, Maarten C. C. M. Hulshof, Jolanda van Dieren, Marieke Vollebergh, Johanna W. van Sandick, Paul Jeene, Christel T. Muijs, Marije Slingerland, Francine E. M. Voncken, Henk Hartgrink, Geert-Jan Creemers, Maurice J. C. van der Sangen, Grard Nieuwenhuijzen, Maaike Berbee, Marcel Verheij, Bas Wijnhoven, Laurens V. Beerepoot, Nadia H. Mohammad, Stella Mook, Jelle P. Ruurda, Piotr Kolodziejczyk, Wojciech P. Polkowski, Lucjan Wyrwicz, Maria Alsina, Manuel Pera, Tania F. Kanonnikoff, Andres Cervantes, Magnus Nilsson, Stefan Monig, Anna D. Wagner, Matthias Guckenberger, Ewen A. Griffiths, Elizabeth Smyth, George B. Hanna, Sheraz Markar, M. Asif Chaudry, Maria A. Hawkins, Edward Cheong, Richard van Hillegersberg, Peter S. N. van Rossum
Summary: This study aimed to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophago-gastric cancer. Through a series of discussions and expert evaluations, a consensus was reached, which can be used for future research in clinical trials.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Marie Louise Holm Milo, Ditte Slot Moller, Tine Bisballe Nyeng, Lone Hoffmann, Henrik Dahl Nissen, Ingelise Jensen, Ebbe Laugaard Lorenzen, Lise Bech Jellesmark Thorsen, Kirsten Melgaard Nielsen, Soren Paaske Johnsen, Jan Brink Valentin, Jan Alsner, Birgitte Vrou Offersen
Summary: This study aimed to report the radiation therapy (RT) doses to the heart and cardiac substructures in breast cancer patients treated with CT-based RT and investigate the potential dose-response relationship between RT dose and coronary artery disease (CAD). The results showed that CAD tended to occur in the part of the heart with the highest left-minus-right dose difference, but no significant risk of CAD was observed at a median follow-up of 7 years.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
M. Ducreux, G. K. Abou-Alfa, T. Bekaii-Saab, J. Berlin, A. Cervantes, T. de Baere, C. Eng, P. Galle, S. Gill, T. Gruenberger, K. Haustermans, A. Lamarca, P. Laurent-Puig, J. M. Llovet, F. Lordick, T. Macarulla, D. Mukherji, K. Muro, R. Obermannova, J. -M. O'Connor, E. M. O'Reilly, P. Osterlund, P. Philip, G. Prager, E. Ruiz-Garcia, B. Sangro, T. Seufferlein, J. Tabernero, C. Verslype, H. Wasan, E. Van Cutsem
Summary: This article summarises expert discussion on the management of patients with hepatocellular carcinoma (HCC), which took place during the 24th World Gastrointestinal Cancer Congress (WGICC) in Barcelona, July 2022. A multidisciplinary approach is essential for optimal diagnosis, staging, and planning of curative and therapeutic options for HCC, considering factors such as liver cirrhosis.
Article
Oncology
Gaelle Saade, Eva Bogaerts, Sophie Chiavassa, Guillaume Blain, Gregory Delpon, Manon Evin, Youssef Ghannam, Ferid Haddad, Karin Haustermans, Charbel Koumeir, Ellina Macaeva, Lydia Maigne, Quentin Mouchard, Noel Servagent, Edmond Sterpin, Stephane Supiot, Vincent Potiron
Summary: Recently, ultrahigh-dose-rate radiation therapy (UHDR-RT) has emerged as a promising strategy to increase the benefit/risk ratio of external RT. However, the differential effect on healthy and tumor tissue is only observable in in vivo models, which limits the amount of work that can be done in a timely manner.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Pieter Populaire, Gilles Defraene, Philippe Nafteux, Lieven Depypere, Johnny Moons, Sofie Isebaert, Karin Haustermans
Summary: This study aimed to investigate the relationship between dose to functional lung volumes (FLV) and treatment-related lung toxicity in locally advanced esophageal cancer (EC) patients. The results showed that an increase in FLV dose between 10 and 20 Gy and a decrease in anatomical lung volume (ALV) were associated with postoperative pulmonary complications.
Article
Oncology
Agon Olloni, Carsten Brink, Ebbe L. Lorenzen, Stefan S. Jeppesen, Lone Hoffmann, Charlotte Kristiansen, Marianne M. Knap, Ditte S. Moller, Lotte Nygard, Gitte F. Persson, Rune S. Thing, Hella MB. Sand, Axel Diederichsen, Tine Schytte
Summary: This study investigated the role of coronary artery calcium score (CACs) as a prognostic marker in locally advanced non-small cell lung cancer (LA-NSCLC) patients. The results showed that CACs did not significantly impact the overall survival of the patients, highlighting the priority of lung cancer treatment.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Eva Oldenburger, Robin De Roover, Kenneth Poels, Tom Depuydt, Sofie Isebaert, Karin Haustermans
Summary: The study aims to report on the accuracy of an automated delineation, treatment plan quality, and duration for vertebral bone metastases using a 1£ 8 Gy regimen in an in-silico scan-(pre)plan-treat (SPT) workflow. The cloud-based emulator system of the Ethos therapy system was utilized to adapt a preplan created on the diagnostic CT to the anatomy-of-the-day using the cone beam CT prior to treatment. The SPT workflow resulted in good coverage of the target volume and acceptable dose to the organs at risk, with the best delivery time and plan homogeneity achieved using a 7-field IMRT plan template.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Nuclear Science & Technology
Isabelle Thierry-Chef, Beate Timmermann, Neige Journy, Marie-Odile Bernier, Richard McNally, Jeremie Dabin, Lorenzo Brualla, Siamak Haghdoost, Adelaida Sarukhan, Karin Haustermans, Inge De Wit, Sofie Isebaert, Yasmin Lassen-Ramshad, Louise Tram Henriksen, Morten Hoyer, Laura Toussaint, Guillaume Boissonnat, Juliette Thariat, Charlotte Demoor-Goldschmidt, Nadia Haddy, Stephanie Bolle, Brice Fresneau, Amel Belhout, Steffen Dreger, Hajo Zeeb, Maria Grazia Andreassi, Jonica Campolo, Eugenio Picano, Andreas Jahnen, Cecile Ronckers, John H. Maduro, Kristina Kjaerheim, Gaute Dohlen, Trude Eid Robsahm, Hilde M. Olerud, Utheya Salini Thevathas, Susmita Afroz, Bjorn Helge Osteras, Uwe Schneider, Linda Walsh, Agnes Dumas, Angela Jackson, Estelle Rage, Marijke De Saint-Hubert, Richard Hardy, Christian Baeumer, Theresa Steinmeier, Suzan Botzenhardt, Martina Wette, Rodney Ortiz, Vadim Chumak
Summary: The use of ionising radiation in medical procedures has greatly benefited paediatric patients, but the long-term health effects need to be evaluated. The HARMONIC project aims to understand the increased risk of cancer and non-cancer effects after exposure to radiation in children with cancer and cardiac defects. It investigates potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life, and risks of second primary cancers. The project also develops software tools for dose reconstruction and builds a biobank to identify biomarkers of radiation-induced adverse health effects.
EPJ NUCLEAR SCIENCES & TECHNOLOGIES
(2023)
Article
Oncology
Lien van Walle, Geert Silversmit, Lieven Depypere, Philippe Nafteux, Hans Van Veer, Elke Van Daele, Yannick Deswysen, Jerome Xicluna, Annelies Debucquoy, Liesbet Van Eycken, Karin Haustermans
Summary: This study aimed to evaluate the association between surgical volume and outcomes of esophageal cancer surgery. The results showed that higher annual surgical volume was associated with lower 90-day mortality and better 5-year overall survival. Therefore, the study supported the centralization of esophageal cancer surgery in hospitals with higher surgical volumes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)