Review
Chemistry, Analytical
Zhaoyuan Lyu, Jiachi Zhou, Shichao Ding, Dan Du, Joseph Wang, Yun Liu, Yuehe Lin
Summary: Single-atom catalysts and nanozymes have gained significant attention in the field of catalysis. Compared to natural enzymes, nanozymes exhibit stronger catalytic activity and higher cost-effectiveness. This review comprehensively overviews the applications of nanozymes in colorimetric biosensing and discusses strategies to improve their catalytic efficiency.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qingyuan Yang, Jiawei Liu, Wentao Cai, Xiao Liang, Zechao Zhuang, Tao Liao, Fengxian Zhang, Weikang Hu, Pengxin Liu, Sanjun Fan, Wenqian Yu, Bingbing Jiang, Cao Li, Dingsheng Wang, Ziqiang Xu
Summary: Single-atom nanozymes (SAzymes), with twisted, nonplanar Fe-O3N2 active sites similar to the non-heme iron center of HppE, were successfully synthesized using carbon dots (CDs) as the support. The Fe-CDs exhibited excellent peroxidase (POD) activity, surpassing the values of conventional SAzymes with planar Fe-N-4. Furthermore, an activatable Fe-CDs-based therapeutic agent with near-infrared enhanced POD activity, photothermal effect, and tumor-targeting ability was developed. This research represents a significant advancement in the design of high-performance SAzymes and provides guidance for future applications in synergistic tumor therapy.
Article
Chemistry, Multidisciplinary
Xianyu Zhu, Jiabin Wu, Ruixue Liu, Huandong Xiang, Wenqi Zhang, Qingchao Chang, Shanshan Wang, Rui Jiang, Feng Zhao, Qiqiang Li, Liang Huang, Liang Yan, Yuliang Zhao
Summary: This study developed an external-field-enhanced nanozyme for tumor theranostics. The nanozyme exhibited peroxidase-like activity and self-cascade enzymatic activity, and showed improved tumor growth inhibition with minimal side effects in vivo through the synergistic effect of radiotherapy and self-cascade enzymatic therapy.
Article
Chemistry, Analytical
Liping Sun, Chao Li, Yong Yan, Yue Yu, Hao Zhao, Zijue Zhou, Feng Wang, Yi Feng
Summary: The study focuses on enhancing the aqueous dispersion and recognition ability of SAzymes by engineering DNA onto them, offering new insights for their application in bioanalysis. By studying the interactions between Fe-N-C SAzymes and DNA, it was found that adenine and thymine had higher adsorption affinity on Fe-N-C SAzymes.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Yang Zhu, Wenyu Wang, Junjie Cheng, Yunteng Qu, Yi Dai, Manman Liu, Jianing Yu, Chengming Wang, Huijuan Wang, Sicong Wang, Chao Zhao, Yuen Wu, Yangzhong Liu
Summary: The Mn/PSAE constructed here demonstrates significant catalytic activity in weakly acidic tumor environments, which enables the generation of sufficient reactive oxygen species (ROS) through a series of cascade reactions to effectively kill tumor cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Engineering, Biomedical
Zihao Wang, Fu-Gen Wu
Summary: Single-atom catalysts are atomically dispersed nanozymes with high atom utilization and excellent catalytic performance. However, undesired aggregation effect can occur during activation and reaction processes, requiring appropriate substrates to stabilize their catalytic activity.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fan, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs), a new type of catalytic nanomaterials with enzyme-mimetic activities, have gained extensive research attention in the fields of chemistry, energy conversion, and environmental purification. Recent studies have demonstrated the great potential of SANs in biological applications, including anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fang, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs) are emerging catalytic nanomaterials with enzyme-like activities, which hold great promise in medical applications. This article presents the recent developments of SANs in anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Article
Engineering, Biomedical
Xianwen Wang, Qianqian Shi, Zhengbao Zha, Dongdong Zhu, Lirong Zheng, Luoxiang Shi, Xianwen Wei, Lian Lian, Konglin Wu, Liang Cheng
Summary: This study highlights the enhanced catalytic activity of nanozymes through the construction of Cu SASs/NPC for photothermal-catalytic antibacterial treatment strategy. The introduction of Cu significantly improves the catalytic performance of nanozymes, effectively killing bacteria and improving sterilization effect. The synergistic PTT-catalytic antibacterial strategy shows almost 100% antibacterial efficiency against E. coli and MRSA, demonstrating wide bio-applications of Cu-containing catalysts in antibacterial and anti-infective treatments.
BIOACTIVE MATERIALS
(2021)
Review
Materials Science, Biomaterials
Xing Lan, Miaomiao Chen, Xin He, Shutao Gao, Xinghua Zhao
Summary: Bacterial infection-related diseases continue to be a significant challenge for global human health. Single-atom nanozymes (SAzymes) have shown promising potential as novel antibacterial agents for the future.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yu Han, Ku Ge, Ying Zhao, Massimo Bottini, Dehui Fan, Wenchang Wu, Luwei Li, Fengsong Liu, Shutao Gao, Xing-Jie Liang, Jinchao Zhang
Summary: In this study, carbon dot-supported Fe single-atom nanozymes with high peroxidase-like activity were fabricated. The nanozymes showed efficient inhibition of tumor cell growth through synergistic chemodynamic and photothermal effects.
Review
Chemistry, Analytical
Fangzheng Wang, Yingying Wang, Huixin Wang, Guanhui Zhao, Jihao Li, Yaoguang Wang
Summary: In recent years, nanozyme materials have become a rapidly developing type of new nanomaterials. They have been widely used by researchers in various fields. Nanozymes, a group of inorganic nanomaterials, can mimic the function of real enzymes. They possess the specificity of natural enzymes for catalyzing specific substrates, as well as the unique electrical conductivity and stability of nanomaterials. Single-atom nanozyme materials have gained popularity due to their higher catalytic activity and tunable structure size, which is advantageous for analytical detection in biosensors and advancements in tumor therapy and antimicrobial therapy.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Bolong Xu, Shanshan Li, Lirong Zheng, Yunhang Liu, Along Han, Jin Zhang, Zhijun Huang, Haijiao Xie, Kelong Fan, Lizeng Gao, Huiyu Liu
Summary: Single-atom nanozymes are a new research frontier in the biomedical fields. A melamine-mediated pyrolysis activation strategy has been used to controllably fabricate iron-based SAzymes with a five-coordinated structure (FeN5). The FeN5 SAzyme shows excellent peroxidase-like activity and significantly enhanced antitumor effect in vitro and in vivo.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
XueQian Xiao, Xiao Hu, Qiming Liu, Yuling Zhang, Guo-Jun Zhang, Shaowei Chen
Summary: Single-atom nanozymes (SAzymes) have emerged as promising alternatives to natural enzymes due to their intrinsic enzyme-like properties and excellent stability. They overcome the major obstacles of low active site density and unclear crystal structure in traditional nanozymes. The well-defined coordination structures and homogeneously dispersed active sites of SAzymes provide rare pathways to investigate catalytic mechanisms. In this review, we summarize the latest progress in the rational design and engineering of SAzymes, as well as their applications in biomedicine and biosensing. We also highlight the remaining challenges and future perspectives of this emerging technology.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Yang Zhu, Yaxin Liao, Jianhua Zou, Junjie Cheng, Yuanbo Pan, Lisen Lin, Xiaoyuan Chen
Summary: Nanomaterials with enzyme-mimicking properties, known as nanozymes, have become an alternative to natural enzymes due to their advantages, such as stability, ease of preparation, and catalytic performance. Single atom nanozymes (SAzymes) have recently been developed, showing superior catalytic performance and selectivity, and have made progress in biomedical applications. This review systematically summarizes the recent advances in SAzyme preparation methods, catalytic mechanisms, and biomedical applications, and discusses their potential challenges and prospects for future development.
Article
Multidisciplinary Sciences
Yucan Peng, Wei Li, Bofei Liu, Weiliang Jin, Joseph Schaadt, Jing Tang, Guangmin Zhou, Guanyang Wang, Jiawei Zhou, Chi Zhang, Yangying Zhu, Wenxiao Huang, Tong Wu, Kenneth E. Goodson, Chris Dames, Ravi Prasher, Shanhui Fan, Yi Cui
Summary: The integrated cooling (i-Cool) textile, designed with a unique functional structure, enhances evaporation ability and sweat evaporation cooling efficiency, while also reducing sweat consumption, showing outstanding performance in heat dissipation and perspiration management.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Xianxian Yao, Ruihong Xie, Yongbin Cao, Jing Tang, Yongzhi Men, Haibao Peng, Wuli Yang
Summary: Triple-negative breast cancer (TNBC) presents a challenge in terms of effective treatment. The use of ferroptosis as a novel cell death mechanism is showing promise in treating TNBC cells. The development of a ferroptosis nanomedicine using SIM loaded nanoparticles demonstrates enhanced therapeutic effects against TNBC cells.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Yucan Peng, Lingling Fan, Weiliang Jin, Yusheng Ye, Zhuojun Huang, Shang Zhai, Xuan Luo, Yinxing Ma, Jing Tang, Jiawei Zhou, Louisa C. Greenburg, Arun Majumdar, Shanhui Fan, Yi Cui
Summary: Coloured low-emissivity films for building walls can help reduce radiative heat exchange between indoor and outdoor environments, saving energy for heating and cooling while providing desired aesthetic effects. These films have high reflectance in the infrared wavelength range and selective reflectance in the visible light wavelength range, contributing to a potential global CO2 emission reduction of 1.14 billion metric tons annually.
NATURE SUSTAINABILITY
(2022)
Article
Materials Science, Multidisciplinary
Jing Tang, Cheng Qin, Hulei Yu, Zezhu Zeng, Lixun Cheng, Binghui Ge, Yue Chen, Wen Li, Yanzhong Pei
Summary: This study focuses on the potential thermoelectric applications of BaAg2Te2, a compound with a Pnma crystal structure that exhibits a remarkably low lattice thermal conductivity. By alloying with Cu at the Ag site, the carrier concentration can be increased and the thermal conductivity can be reduced, leading to enhanced thermoelectric performance.
MATERIALS TODAY PHYSICS
(2022)
Article
Engineering, Biomedical
Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang
Summary: In this study, a metal-organic framework (MOF)-red blood cell (RBC) membrane-camouflaged multi-drug-delivery nanoplatform was designed and fabricated for combined ferroptosis-apoptosis treatment of multidrug-resistant cancer. The nanoplatform, created through a solvothermal synthesis process, demonstrated the ability to deplete glutathione, increase reactive oxidative species oxidative stress, and exhibit remarkable anticancer properties. This research provides a new strategy for overcoming multidrug resistance.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Huijuan Wu, Lili Chen, Suiting Ning, Xiaodie Zhao, Shuping Deng, Ning Qi, Feng Ren, Zhiquan Chen, Jing Tang
Summary: In this study, Ga-doped In2O3 with nanosized pore structures were prepared using a hydrothermal method combined with spark plasma sintering. The introduction of nanopores significantly reduced the thermal conductivity of the material, resulting in a high ZT value of 0.383 at 800 degrees C. This research indicates that nanopores can serve as competitive strategy for achieving high ZT values in thermoelectric materials.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Multidisciplinary Sciences
Jinxing Li, Yuxin Liu, Lei Yuan, Baibing Zhang, Estelle Spear Bishop, Kecheng Wang, Jing Tang, Yu-Qing Zheng, Wenhui Xu, Simiao Niu, Levent Beker, Thomas L. Li, Gan Chen, Modupeola Diyaolu, Anne-Laure Thomas, Vittorio Mottini, Jeffrey B. -H. Tok, James C. Y. Dunn, Bianxiao Cui, Sergiu P. Pasca, Yi Cui, Aida Habtezion, Xiaoke Chen, Zhenan Bao
Summary: Neurotransmitters play crucial roles in regulating neural circuit dynamics in the central and peripheral nervous systems, including the gastrointestinal tract. However, there is a lack of bioelectronic tools for real-time monitoring of neurotransmitter dynamics in vivo, especially in the enteric nervous system. In this study, the researchers developed a tissue-mimicking, stretchable neurochemical biological interface called NeuroString, which allows chronic in vivo real-time monitoring of monoamine levels in the brain and serotonin dynamics in the gut. This interface has the potential for studying the impact of neurotransmitters on gut microbes and brain-gut communication.
Article
Multidisciplinary Sciences
Haiyan Mao, Jing Tang, Gregory S. Day, Yucan Peng, Haoze Wang, Xin Xiao, Yufei Yang, Yuanwen Jiang, Shuo Chen, David M. Halat, Alicia Lund, Xudong Lv, Wenbo Zhang, Chongqing Yang, Zhou Lin, Hong-Cai Zhou, Alexander Pines, Yi Cui, Jeffrey A. Reimer
Summary: In this study, new sustainable, solid-state, polyamine-appended, cyanuric acid-stabilized melamine nanoporous networks (MNNs) were successfully synthesized at the kilogram scale via dynamic combinatorial chemistry (DCC) for effective and high-capacity carbon dioxide capture. The reaction mechanisms of polyamine-appended MNNs with carbon dioxide were elucidated, demonstrating high adsorption capacity, fast adsorption time, low cost, and extraordinary stability to cycling by flue gas.
Article
Materials Science, Multidisciplinary
Kun Cheng, Zhonglin Bu, Jing Tang, Xinyue Zhang, Xiang Meng, Wen Li, Yanzhong Pei
Summary: Mg2(Si,Sn) alloys, composed of abundant and non-toxic constituents, have been identified as a promising n-type thermoelectric material due to their large band degeneracy and strong phonon scattering caused by point defects. The optimization of carrier concentration through Bi-doping and the minimization of Mg oxidation by tantalum-sealing technique have enabled the demonstration of thermoelectric efficiency at a device level.
MATERIALS TODAY PHYSICS
(2022)
Article
Biotechnology & Applied Microbiology
Yuanwen Jiang, Artem A. Trotsyuk, Simiao Niu, Dominic Henn, Kellen Chen, Chien-Chung Shih, Madelyn R. Larson, Alana M. Mermin-Bunnell, Smiti Mittal, Jian-Cheng Lai, Aref Saberi, Ethan Beard, Serena Jing, Donglai Zhong, Sydney R. Steele, Kefan Sun, Tanish Jain, Eric Zhao, Christopher R. Neimeth, Willian G. Viana, Jing Tang, Dharshan Sivaraj, Jagannath Padmanabhan, Melanie Rodrigues, David P. Perrault, Arhana Chattopadhyay, Zeshaan N. Maan, Melissa C. Leeolou, Clark A. Bonham, Sun Hyung Kwon, Hudson C. Kussie, Katharina S. Fischer, Gurupranav Gurusankar, Kui Liang, Kailiang Zhang, Ronjon Nag, Michael P. Snyder, Michael Januszyk, Geoffrey C. Gurtner, Zhenan Bao
Summary: Smart bandages based on multimodal wearable devices have the potential to monitor and intervene in the healing process of chronic wounds. However, the integration of sensors and stimulators in current smart bandage technologies is limited. In this study, a flexible bioelectronic system with wireless power, closed-loop sensing and stimulation circuits, and skin-interfacing hydrogel electrodes with switchable adhesion was developed to address these challenges. The wound care system showed improved healing and tissue regeneration in preclinical wound models.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yucan Peng, Jian-Cheng Lai, Xin Xiao, Weiliang Jin, Jiawei Zhou, Yufei Yang, Xin Gao, Jing Tang, Lingling Fan, Shanhui Fan, Zhenan Bao, Yi Cui
Summary: Space heating and cooling consume a significant amount of global energy, and the development of advanced materials, such as colorful low-emissivity paints, offers a solution to reduce energy consumption. These paints provide both aesthetic appeal and infrared reflectance properties, effectively reducing heat exchange with the environment and facilitating energy savings. The versatility of these paints makes them suitable for various applications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Environmental
Hui Wang, Madasamy Thangamuthu, Zhibin Wu, Jianlong Yang, Hongzhao Yuan, Mustafa Kemal Bayazit, Junwang Tang
Summary: Photocatalytic liquid water reforming of methanol using sulphur doped graphitic carbon nitride (SCN) has been developed to efficiently produce hydrogen, reducing CO2 emissions and energy consumption. The hydrogen yield is dependent on pH and reaction temperature. Sulphur doping improves photocatalytic activity by narrowing the bandgap and enhancing charge separation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Proceedings Paper
Automation & Control Systems
Jing Tang, Hengda Bao, Guanjun Liu
Summary: This paper introduces a training framework based on neural networks to learn entity ID representation, enhancing recommendation performance and avoiding issues related to sparsity and high dimensionality. The method effectively improves training efficiency for multi-class models by masking and predicting statistical values of IDs.
2021 4TH INTERNATIONAL CONFERENCE ON INTELLIGENT AUTONOMOUS SYSTEMS (ICOIAS 2021)
(2021)
Article
Multidisciplinary Sciences
Xueli Zheng, Jing Tang, Alessandro Gallo, Jose A. Garrido Torres, Xiaoyun Yu, Constantine J. Athanitis, Emily May Been, Peter Ercius, Haiyan Mao, Sirine C. Fakra, Chengyu Song, Ryan C. Davis, Jeffrey A. Reimer, John Vinson, Michal Bajdich, Yi Cui
Summary: The efficiency of the synthesis of renewable fuels and feedstocks from electrical sources is limited by the sluggish water oxidation reaction. Single-atom catalysts show promise in designing high-performance water oxidation catalysts, with the key being the oxidation state and coordination environment of the active sites. The presence of highly oxidized Ir single atom was found to enhance the water oxidation activity of IrNiFe SACs, highlighting the potential for improved catalyst performance in operando conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
