Review
Dentistry, Oral Surgery & Medicine
Wim Teughels, Lorenz Seyssens, Veronique Christiaens, Andy Temmerman, Ana B. B. Castro, Jan Cosyn
Summary: Based on the analysis of four randomized controlled trials, it is found that the adjunctive use of local or systemic antimicrobials during surgical therapy for peri-implantitis does not improve the clinical efficacy in terms of pocket probing depth reduction. The use of systemic antimicrobials only showed disease resolution in 50% of cases after one year, and the true effect of local antimicrobials remains unclear.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Pharmacology & Pharmacy
Milica Velickovic, Aleksandar Arsenijevic, Aleksandar Acovic, Dragana Arsenijevic, Jelena Milovanovic, Jelena Dimitrijevic, Zeljko Todorovic, Marija Milovanovic, Tatjana Kanjevac, Nebojsa Arsenijevic
Summary: Periodontal diseases result from imbalance between oral microbial communities and host immune response, with Galectin-3 playing a role in modulating microbial composition and immune homeostasis. Clinical studies have shown increased Galectin-3 expression in periodontal diseases, suggesting potential therapeutic targeting in this field.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Donald A. Curtis, Guo-Hao Lin, Yogalakshmi Rajendran, Tsegazeab Gessese, Jyotirmaie Suryadevara, Yvonne L. Kapila
Summary: Periodontal health in the elderly is influenced by numerous factors, necessitating individualized treatment plans, along with the importance of preventative treatment and patient-specific maintenance plans.
PERIODONTOLOGY 2000
(2021)
Review
Polymer Science
Ramkumar Yadav, Anoj Meena, Amar Patnaik
Summary: Biomaterials play a significant role in dental composite materials and implants, requiring evaluation of their physical, mechanical, wear, and biocompatibility properties. This review focuses on the essential features associated with the mechanical, biological, and microstructural properties of biomaterials used in dental composites or implants. It also explores the successful use of diverse materials and processing techniques to enhance the characteristics of dental materials or implants.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Danae Anastasia Apatzidou
Summary: Tobacco smoking is related to periodontal disease through various mechanisms, including inflammation, changes in microbial communities, and compromised tissue healing. Studies have shown that smoking affects clinical indices, microbial flora, and inflammatory and immune responses, as well as treatment outcomes for periodontal disease and implant therapy. Passive smoking also has potential harmful effects, highlighting the importance of smoking cessation.
PERIODONTOLOGY 2000
(2022)
Review
Infectious Diseases
Asma Gasmi Benahmed, Amin Gasmi, Torsak Tippairote, Pavan Kumar Mujawdiya, Oleksandr Avdeev, Yurii Shanaida, Geir Bjorklund
Summary: Dental implants are commonly used to replace lost teeth, and titanium implants have a high success rate. However, there is an increasing risk of peri-implantitis, an inflammatory disease that affects the tissues around the implant. This review highlights the impact of different metabolic conditions on peri-implantitis and emphasizes the importance of considering both local and systemic factors in dental implant procedures and treatment.
Article
Materials Science, Multidisciplinary
Agata Sotniczuk, Halina Garbacz
Summary: This article summarizes several strategies proposed in recent years to optimize the properties of nanostructured titanium products for dental applications, including bulk modifications, surface modifications, and deposition of bioactive coatings. Additionally, insights are provided on how changes in microstructure induced by the fabrication of nanograined Ti can be successfully exploited to improve surface properties.
ADVANCED ENGINEERING MATERIALS
(2021)
Review
Dermatology
Shuangfei Liu, Huan Yang, Jinru Song, Yue Zhang, Ahmed T. H. Abualhssain, Bin Yang
Summary: Keloid, a fibroproliferative disorder of the skin, has genetic heterogeneity and susceptibility among different races and ethnicities. Multiple loci and specific gene variants on chromosomes are associated with keloid pathogenesis, but the genetic mechanism of keloid formation remains unknown. In this review, current studies on heredity, genetic polymorphisms, predisposing genes, DNA methylation, and non-coding RNA are evaluated and summarized. The aim is to better understand the genetics and epigenetics of keloids and develop new therapeutic approaches.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Microbiology
Maria Carmen Sanchez, Andrea Alonso-Espanol, Honorato Ribeiro-Vidal, Bettina Alonso, David Herrera, Mariano Sanz
Summary: Microbial biofilm modeling has advanced in sophistication and scope, with a focus on studying periodontal and peri-implant diseases. A biofilm static model using representative bacteria showed a similar pattern to in vivo subgingival biofilms, leading to the development of standardized methodologies. Testing in different applications and evolving to dynamic biofilm models have provided insights into the formation and behavior of microbial communities when exposed to antimicrobial compounds.
Editorial Material
Multidisciplinary Sciences
Ran Elkon, Reuven Agami
Summary: Basic design principles that protect enhancer networks against the harmful effects of genetic mutations have been elucidated.
Article
Dentistry, Oral Surgery & Medicine
Andrea Ravida, Maria Vera Rodriguez, Muhammad H. A. Saleh, Matthew Galli, Musa Qazi, Giuseppe Troiano, Hom-Lay Wang, Pablo Galindo Moreno
Summary: This study found that the grading of periodontitis has an impact on implant failure and the occurrence of peri-implantitis, but there is no direct correlation between higher-level stages and grades and the prevalence of peri-implantitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Editorial Material
Dentistry, Oral Surgery & Medicine
Giovanpaolo Pini Prato, Riccardo Di Gianfilippo
Summary: To fully comprehend the evolution of periodontal plastic surgery, it is important to delve into its past challenges and successes over the last 70 years, from the 1950s to today. This editorial provides a perspective on the field, highlighting the interrelationships between influential surgical techniques and advancements in research methodology. The evolution of periodontal plastic surgery is a story of scientific progress and ongoing research, fostering a sense of community and shared knowledge.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Materials Science, Multidisciplinary
R. Jayasree, K. Raghava, M. Sadhasivam, P. V. V. Srinivas, R. Vijay, K. G. Pradeep, T. N. Rao, D. Chakravarty
Summary: This work presents the fabrication of bilayered single-piece Ti6Al4V-YSZ dental implants using spark plasma sintering. A customized tapered die was used to produce a one-step single component with different materials having widely varying sintering temperatures. The bi-layered implants, with Ti6Al4V acting as the fixture and YSZ as the crown, overcome the limitations of conventional two-piece or three-piece implants. These implants exhibit excellent mechanical and in-vitro biological properties, including good biocompatibility, non-cytotoxicity, good cell adhesion, and hemo-compatibility, making them suitable for dental applications.
Article
Dentistry, Oral Surgery & Medicine
Jenna C. Hyer, David E. Deas, A. Archontia Palaiologou, Marcel E. Noujeim, Michael J. Mader, Brian L. Mealey
Summary: Enhancements in digital images did not significantly improve the detection of dental calculus on radiographs. Increasing the area of calculus on the root surface and the size of calculus deposits led to improved sensitivity in detection.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Gastroenterology & Hepatology
Kevimy Agossa, Lidia Roman, Marjolaine Gosset, Clara Yzet, Mathurin Fumery
Summary: Patients with inflammatory bowel disease (IBD) are at increased risk for periodontitis and caries. Some evidence suggests that periodontitis might be associated with a lower response to anti-TNF medications. However, there is no reliable evidence to suggest that IBD patients are at greater risk for complications during routine dental care. Guidelines for dental management focusing on early detection and treatment of infections before immunosuppressant use are recommended.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Biochemical Research Methods
Hulya Cevik-Aras, Goran Kjeller, Lena Larsson
JOURNAL OF IMMUNOLOGICAL METHODS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Tobias Fretwurst, Carlos Garaicoa-Pazmino, Katja Nelson, William Giannobile, Cristiane H. Squarize, Lena Larsson, Rogerio M. Castilho
CLINICAL ORAL IMPLANTS RESEARCH
(2020)
Article
Engineering, Biomedical
Yuki Ichioka, Farah Asa'ad, Behnosh Ohrnell Malekzadeh, Anna Westerlund, Lena Larsson
Summary: The study found that the surface characteristics of minimally rough titanium do impact DNA damage and repair pathways, including epigenetic factors. Compared to smooth titanium, minimally rough titanium surfaces induce less DNA damage and higher levels of DNA repair cells.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Biochemistry & Molecular Biology
Ismael Khouly, Rosalie Salus Braun, Michelle Ordway, Bradley Eric Aouizerat, Iya Ghassib, Lena Larsson, Farah Asa'ad
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Dentistry, Oral Surgery & Medicine
Carlotta Dionigi, Lena Larsson, Olivier Carcuac, Tord Berglundh
JOURNAL OF CLINICAL PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Tobias Fretwurst, Janina Mueller, Lena Larsson, Peter Bronsert, Derek Hazard, Rogerio M. Castilho, Ralf Kohal, Katja Nelson, Gerhard Iglhaut
Summary: The pilot study aimed to histologically classify inflamed peri-implant soft tissue around ceramic implants compared to titanium implants. It found a similar cell population distribution in peri-implantitis around both types of implants, with differences potentially dependent on the patient's specific immune status.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Farah Asa'ad, Goda Pelanyte, Jincy Philip, Christer Dahlin, Lena Larsson
Article
Engineering, Biomedical
Yuki Ichioka, Jan Derks, Gunnar Dahlen, Tord Berglundh, Lena Larsson
Summary: In this in vitro study, different mechanical decontamination techniques were used on biofilm-contaminated titanium surfaces to evaluate surface cleanness and cytocompatibility. The results showed that shot-blasted surfaces had higher residual bacterial counts with certain cleaning techniques, and differed in decontamination effectiveness and cytocompatibility compared to non-modified surfaces. The use of cleaning devices on shot-blasted surfaces may have some impact on cytocompatibility.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Lena Larsson, Carlos Garaicoa-Pazmino, Farah Asa'ad, Rogerio Moraes Castilho
Summary: This review presents the current understanding of endotoxin tolerance (ET) in chronic inflammatory diseases and explores its potential connection with periodontitis. Mechanisms and pathways such as Toll-like receptors, nuclear factor κB, immune cell apoptosis, epigenetics, and microRNAs regulate ET and contribute to chronic inflammatory diseases including periodontitis. While the direct relationship between ET and periodontal destruction is not fully understood, evidence suggests potential tolerization of periodontal ligament cells and gingival tissues with reduced levels of Toll-like receptors. Further research is needed to investigate the crucial role of ET in the pathogenesis of periodontal diseases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuki Ichioka, Jan Derks, Gunnar Dahlen, Tord Berglundh, Lena Larsson
Summary: The study evaluated biofilm removal and cytocompatibility after chemo-mechanical surface decontamination. Alkaline electrized water and citric acid were found to be superior on rough surfaces, while N-acetyl-L-cysteine and alkaline electrized water were better for promoting cytocompatibility.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Ismael Khouly, Simon Pardinas Lopez, Silvia Maria Diaz Prado, Luca Ferrantino, Josephine Kalm, Lena Larsson, Farah Asa'ad
Summary: This study aimed to evaluate the relationship between implant failure (IF) due to peri-implantitis (PIT) and global DNA methylation levels. The study found higher global DNA methylation levels in gingival tissue samples compared to bone, regardless of the study groups. However, there were similar global DNA methylation levels between the IF and periodontally healthy (PH) groups. Furthermore, the study revealed differences in global DNA methylation levels between gingival tissues and bone, suggesting different epigenetic responses between tissues within the same microenvironment. Further research is needed to clarify these findings and evaluate the role of epigenetic modifications in IF caused by PIT.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Carlotta Dionigi, Lena Larsson, Julia C. Difloe-Geisert, Nicola U. Zitzmann, Tord Berglundh
Summary: Differences in the cellular expression of epigenetic markers and oxidative stress were observed in periodontitis lesions between smokers and non-smokers, suggesting that smoking may downregulate host response and epigenetic mechanisms in periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Editorial Material
Immunology
Farah Asa'ad, Young-Dan Cho, Lena Larsson
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shogo Maekawa, Young-Dan Cho, Frederic Kauffmann, Yao Yao, James V. Sugai, Xiaoyang Zhong, Caroline Schmiedeler, Nitin Kinra, Alyssa Moy, Lena Larsson, Joerg Lahann, William V. Giannobile
Summary: Dental implants are crucial for individuals with tooth loss. A study shows that using chemical vapor deposition (CVD) technology and bone morphogenetic protein (BMP) gene delivery on titanium surfaces can promote bone regeneration and bone-to-implant contact.
ADVANCED MATERIALS INTERFACES
(2022)
