期刊
ORGANIC LETTERS
卷 24, 期 28, 页码 5034-5039出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01768
关键词
-
资金
- NIH [5R01GM125920-03]
A direct formylation method using cost-effective deuterated glyoxylic acid as the formylation agent has been developed. This method allows for the synthesis of structurally diverse C1-deuterated 3-formylindoles with high D-incorporation using visible light and air as the terminal oxidant.
Direct formylation of feedstock indoles with newly developed, cost-effective deuterated glyoxylic acid as formylation agent under visible light and air (O2) as terminal oxidant has been developed. An isatin byproduct produced from the corresponding indole reactant serves as a facilitator for the formylation process. The simple, mild, metal-and oxidant-free protocol enables the synthesis of structurally diverse C1-deuterated 3-formylindoles with broad functional group tolerance and late-stage functionalization at a high level of D-incorporation (95-99%).
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