Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice
出版年份 2022 全文链接
标题
Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice
作者
关键词
-
出版物
NEUROPHARMACOLOGY
Volume -, Issue -, Pages 109203
出版商
Elsevier BV
发表日期
2022-08-03
DOI
10.1016/j.neuropharm.2022.109203
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Everolimus as a possible prenatal treatment of in utero diagnosed subependymal lesions in tuberous sclerosis complex: a case report
- (2021) Sergio Cavalheiro et al. CHILDS NERVOUS SYSTEM
- mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus
- (2021) Tomas Petrasek et al. Journal of Neurodevelopmental Disorders
- The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease
- (2020) Jiang-Fan Chen et al. Purinergic Signalling
- Purinergic signaling in infectious diseases of the central nervous system
- (2020) Vinícius Santos Alves et al. BRAIN BEHAVIOR AND IMMUNITY
- A randomized controlled trial with everolimus for IQ and autism in tuberous sclerosis complex
- (2019) Iris E. Overwater et al. NEUROLOGY
- Evaluation of Fluoro-Jade C Staining: Specificity and Application to Damaged Immature Neuronal Cells in the Normal and Injured Mouse Brain
- (2019) Takuya Ikenari et al. NEUROSCIENCE
- Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect
- (2018) Guoping Liu et al. BRAIN RESEARCH
- Uncoupling of ER/Mitochondrial Oxidative Stress in mTORC1 Hyperactivation-Associated Skin Hypopigmentation
- (2018) Fei Yang et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease
- (2018) António C. Silva et al. NEUROBIOLOGY OF DISEASE
- Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
- (2018) Claudio Soto et al. NATURE NEUROSCIENCE
- Modulation of Microglial Activation by Adenosine A2a Receptor in Animal Models of Perinatal Brain Injury
- (2018) Marina Colella et al. Frontiers in Neurology
- The P2X7 Receptor in Infection and Inflammation
- (2017) Francesco Di Virgilio et al. IMMUNITY
- A Novel Focal Seizure Pattern Generated in Superficial Layers of the Olfactory Cortex
- (2017) Laura Uva et al. JOURNAL OF NEUROSCIENCE
- The biphasic function of microglia in ischemic stroke
- (2017) Yuanyuan Ma et al. PROGRESS IN NEUROBIOLOGY
- Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration
- (2017) Tian Zhou et al. Frontiers in Neuroanatomy
- Everolimus for treatment of tuberous sclerosis complex-associated neuropsychiatric disorders
- (2017) Darcy A. Krueger et al. Annals of Clinical and Translational Neurology
- mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type
- (2016) Daojing Li et al. FASEB JOURNAL
- Adenosine Type A2A Receptor in Peripheral Cell from Patients with Alzheimer’s Disease, Vascular Dementia, and Idiopathic Normal Pressure Hydrocephalus: A New/Old Potential Target
- (2016) Beatrice Arosio et al. JOURNAL OF ALZHEIMERS DISEASE
- Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study
- (2016) Jacqueline A French et al. LANCET
- Long-term treatment of epilepsy with everolimus in tuberous sclerosis
- (2016) Darcy A. Krueger et al. NEUROLOGY
- Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex
- (2016) A.C. Felix-Ortiz et al. NEUROSCIENCE
- Olfactory abnormalities in temporal lobe epilepsy
- (2015) M. Desai et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Neurological and neuropsychiatric aspects of tuberous sclerosis complex
- (2015) Paolo Curatolo et al. LANCET NEUROLOGY
- Pilot Validation of the Tuberous Sclerosis-Associated Neuropsychiatric Disorders (TAND) Checklist
- (2015) Loren Leclezio et al. PEDIATRIC NEUROLOGY
- Tuberous Sclerosis Associated Neuropsychiatric Disorders (TAND) and the TAND Checklist
- (2015) Petrus J. de Vries et al. PEDIATRIC NEUROLOGY
- Regulation of autophagy by amino acids and MTOR-dependent signal transduction
- (2014) Alfred J. Meijer et al. AMINO ACIDS
- The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype
- (2014) Lucia Lisi et al. Journal of Neuroinflammation
- Mammalian Target of Rapamycin Inhibitors for Intractable Epilepsy and Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex
- (2014) Michael Cardamone et al. JOURNAL OF PEDIATRICS
- Phagocytosis of Microglia in the Central Nervous System Diseases
- (2014) Ruying Fu et al. MOLECULAR NEUROBIOLOGY
- Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits
- (2014) Guomei Tang et al. NEURON
- The Neurology of mTOR
- (2014) Jonathan O. Lipton et al. NEURON
- Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
- (2013) Sovan Sarkar BIOCHEMICAL SOCIETY TRANSACTIONS
- Involvement of P2X4 receptors in hippocampal microglial activation afterstatus epilepticus
- (2013) Lauriane Ulmann et al. GLIA
- Rapamycin unbalances the polarization of human macrophages to M1
- (2013) Alessia Mercalli et al. IMMUNOLOGY
- Immunomagnetic enrichment and flow cytometric characterization of mouse microglia
- (2013) Supinder S. Bedi et al. JOURNAL OF NEUROSCIENCE METHODS
- Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma
- (2013) D. A. Krueger et al. NEUROLOGY
- Temporal and Mosaic Tsc1 Deletion in the Developing Thalamus Disrupts Thalamocortical Circuitry, Neural Function, and Behavior
- (2013) Elizabeth A. Normand et al. NEURON
- Autophagy and apoptosis dysfunction in neurodegenerative disorders
- (2013) Saeid Ghavami et al. PROGRESS IN NEUROBIOLOGY
- The TSC-mTOR pathway regulates macrophage polarization
- (2013) Vanessa Byles et al. Nature Communications
- Blocking mTORC1 activity by rapamycin leads to impairment of spatial memory retrieval but not acquisition in C57BL/6J mice
- (2012) Alev Deli et al. BEHAVIOURAL BRAIN RESEARCH
- Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration
- (2012) Keiko Ohsawa et al. JOURNAL OF NEUROCHEMISTRY
- Mitochondria, oxidative stress and neurodegeneration
- (2012) Antonio Federico et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex
- (2012) R. Michelle Reith et al. NEUROBIOLOGY OF DISEASE
- A Smell That Causes Seizure
- (2012) Minh Q. Nguyen et al. PLoS One
- The mTOR Inhibitor Rapamycin Has Limited Acute Anticonvulsant Effects in Mice
- (2012) Adam L. Hartman et al. PLoS One
- Cellular function and molecular structure of ecto-nucleotidases
- (2012) Herbert Zimmermann et al. Purinergic Signalling
- Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
- (2012) Atsushi Sato et al. Nature Communications
- Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
- (2011) Loredana Stoica et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Purinergic signalling: From normal behaviour to pathological brain function
- (2011) Geoffrey Burnstock et al. PROGRESS IN NEUROBIOLOGY
- Adenosine 2A receptor: a crucial neuromodulator with bidirectional effect in neuroinflammation and brain injury
- (2011) Shuang-Shuang Dai et al. REVIEWS IN THE NEUROSCIENCES
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- (2011) R. C. Paolicelli et al. SCIENCE
- Decreased Clearance of CNS -Amyloid in Alzheimer's Disease
- (2010) K. G. Mawuenyega et al. SCIENCE
- Microglial Interactions with Synapses Are Modulated by Visual Experience
- (2010) Marie-Ève Tremblay et al. PLOS BIOLOGY
- The tuberous sclerosis complex
- (2009) Ksenia A. Orlova et al. Annals of the New York Academy of Sciences
- The natural history of epilepsy in tuberous sclerosis complex
- (2009) Catherine J. Chu-Shore et al. EPILEPSIA
- Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β
- (2009) Alessandro Michelucci et al. JOURNAL OF NEUROIMMUNOLOGY
- The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy
- (2009) L.-H. Zeng et al. JOURNAL OF NEUROSCIENCE
- Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals
- (2009) H. Wake et al. JOURNAL OF NEUROSCIENCE
- Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
- (2008) Ling-Hui Zeng et al. ANNALS OF NEUROLOGY
- Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy
- (2008) S. A. Villalta et al. HUMAN MOLECULAR GENETICS
- The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
- (2008) Thomas Weichhart et al. IMMUNITY
- Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis
- (2008) Dan Ehninger et al. NATURE MEDICINE
- Synuclein activates microglia in a model of Parkinson's disease
- (2007) Xiaomin Su et al. NEUROBIOLOGY OF AGING
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started