The association between urinary pentosidine levels and cognition in drug-naive patients with Parkinson's disease

Advanced glycation end products (AGEs) are suggested to play a potential role in the progression of Parkinson's disease (PD). The association between urinary levels of pentosidine, one of the best-characterized AGEs, and clinical conditions such as motor severity and cognition were investigated in patients with PD. Data on the clinical characteristics and urinary levels of pentosidine for 44 drug-naive patients aged 60 years or older with PD were collected. The association between urinary pentosidine levels and severity of motor symptoms and cognition was analyzed using the Montreal Cognitive Assessment Scale (MoCA). Urinary pentosidine values increased with age (R-2 =0.286, p < 0.001) and were negatively correlated with the MoCA score (R-2 = 0.255, p= 0.001). Urinary pentosidine levels were significantly correlated with age (r = 0.535, p < 0.001), Hoehn-Yahr stage (r = 0.340, p <0.05), and total MoCA score (r = - 0.505, p < 0.001). Multiple linear regression analysis showed that older age (beta= 0.543; 95% confidence interval [CI] 0.300, 1.307; p =0.003) was significantly associated with severity of motor symptoms, and that older age (beta = - 0.456; 95% CI - 0.287, - 0.054; p = 0.005) and urinary pentosidine levels (beta = - 0.311; 95% CI - 0.428, - 0.004; p = 0.046) were significantly associated with a lower MoCA score. Urinary pentosidine levels were significantly associated with lower cognition in drug-naive PD patients. These findings have important clinical implications and suggest that pentosidine may be a potential marker for cognitive impairment in early PD.

Automated summary

The study found that urinary levels of pentosidine were associated with motor severity and cognition in patients with Parkinson's disease. Urinary pentosidine levels increased with age and were negatively correlated with cognitive ability. The levels were also significantly correlated with age, disease stage, and overall cognitive function. These findings have important clinical implications and suggest that pentosidine may be a potential marker for cognitive impairment in early Parkinson's disease.