4.7 Article

Cerebellum anatomy predicts individual risk-taking behavior and risk tolerance

期刊

NEUROIMAGE
卷 254, 期 -, 页码 -

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2022.119148

关键词

Risk tolerance; Balloon analogue risk task; Cerebellum; Hierarchical Bayesian modeling

资金

  1. National Institutes of Health [R01-HL102119, R01-MH107571, R01-NS113889, R21-AG051981]
  2. Shanghai International Studies University Research Projects [20171140020]
  3. National Natural Science Foundation of China [71942003, 72101156]
  4. Program for Professors of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning [TP2016020, GZ2019003]

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Human risk tolerance varies from person to person, and individuals often have different preferences when facing similar risky situations. This study found a strong association between left cerebellum gray matter volume and individual risk-taking behavior and risk tolerance, suggesting the important role of the cerebellum in risk tolerance.
Human risk tolerance is highly idiosyncratic and individuals often show distinctive preferences when faced with similar risky situations. However, the neural underpinnings of individual differences in risk-taking remain un-clear. Here we combined structural and perfusion MRI and examined the associations between brain anatomy and individual risk-taking behavior/risk tolerance in a sample of 115 healthy participants during the Balloon Ana-logue Risk Task, a well-established sequential risky decision paradigm. Both whole brain and region-of-interest analyses showed that the left cerebellum gray matter volume (GMV) has a strong association with individual risk-taking behavior and risk tolerance, outperforming the previously reported associations with the amygdala and right posterior parietal cortex (PPC) GMV. Left cerebellum GMV also accounted for risk tolerance and risk-taking behavior changes with aging. However, regional cerebral blood flow (CBF) provided no additional predictive power. These findings suggest a novel cerebellar anatomical contribution to individual differences in risk toler-ance. Further studies are necessary to elucidate the underestimated important role of cerebellum in risk-taking.

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