Article
Immunology
Yufei Mo, Kelvin Kai-Wang To, Runhong Zhou, Li Liu, Tianyu Cao, Haode Huang, Zhenglong Du, Chun Yu Hubert Lim, Lok-Yan Yim, Tsz-Yat Luk, Jacky Man-Chun Chan, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Owen Tak-Yin Tsang, Anthony Raymond Tam, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Zhiwei Chen
Summary: This study focused on mitochondrial dysfunction in T-cell subsets during SARS-CoV-2 infection and found an association between this dysfunction and impaired T-cell functionality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ling Ni, Meng-Li Cheng, Yu Feng, Hui Zhao, Jingyuan Liu, Fang Ye, Qing Ye, Gengzhen Zhu, Xiaoli Li, Pengzhi Wang, Jing Shao, Yong-Qiang Deng, Peng Wei, Fang Chen, Cheng-Feng Qin, Guoqing Wang, Fan Li, Hui Zeng, Chen Dong
Summary: Severe COVID-19 patients with acute respiratory distress syndrome (ARDS) showed specific antibody responses to SARS-CoV-2, but had reduced levels of NK cells and CD8(+) T cells, as well as decreased IFN gamma expression in CD4(+) T cells. Their lymphocytes in peripheral blood failed to produce IFN gamma against viral proteins, highlighting the importance of cellular immunity in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Lukas Borcherding, Alime Sema Teksen, Bianca Grosser, Tina Schaller, Klaus Hirschbuehl, Rainer Claus, Oliver Spring, Michael Wittmann, Christoph Roemmele, Eva Sipos, Bruno Maerkl
Summary: Studies have shown that in COVID-19 patients, professional antigen-presenting cells increase in number in the later stages of the disease, but fail to mature, resulting in the inability to activate T cells, affecting the immune response.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Lidewij W. Ruemke, Wouter L. Smit, Ailko Bossink, Gijs J. M. Limonard, Danya Muilwijk, Lenneke E. M. Haas, Chantal Reusken, Sanne van der Wal, Bing J. Thio, Yvonne M. G. van Os, Hendrik Gremmels, Jeffrey M. Beekman, Monique Nijhuis, Annemarie M. J. Wensing, Michiel Heron, Steven F. T. Thijsen
Summary: This study longitudinally characterized cellular immune responses in COVID-19 patients, and found that severe patients had impaired early IFN-γ-secreting virus-specific T-cell responses compared to moderate patients. In addition, a substantial proportion of T-cell response was directed against the conserved membrane protein, which may have implications for diagnostics and vaccine design. These findings further support the role of dysregulated adaptive immunity in COVID-19 immunopathogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Andreas Toernell, Elin Blick, Samer Al-Dury, Hanna Grauers Wiktorin, Johan Waern, Johan Ringlander, Sigrun Einarsdottir, Magnus Lindh, Kristoffer Hellstrand, Martin Lagging, Anna Martner
Summary: This study aimed to characterize innate and adaptive immune functions, including antigen-specific T cell responses to COVID-19 vaccination, in patients with compensated and decompensated cirrhosis. The results showed that cirrhotic patients had significantly different immune phenotype and function compared to healthy controls after COVID-19 vaccination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Beeke Tappe, Chris D. Lauruschkat, Lea Strobel, Jezreel Pantaleon Garcia, Oliver Kurzai, Silke Rebhan, Sabrina Kraus, Elena Pfeuffer-Jovic, Lydia Bussemer, Lotte Possler, Matthias Held, Kerstin Huenniger, Olaf Kniemeyer, Sascha Schaeuble, Axel A. Brakhage, Gianni Panagiotou, P. Lewis White, Hermann Einsele, Juergen Loeffler, Sebastian Wurster
Summary: Patients with COVID-19 are vulnerable to deadly secondary fungal infections, but there is limited experimental evidence on the impact of SARS-CoV-2 on antifungal immunity. This study found that T-helper cells in COVID-19 patients had weakened activation and cytokine release in response to fungal antigens, and there was reduced granulocyte activation and fungal killing capacity. These weakened immune responses to fungi were not associated with COVID-19 severity or corticosteroid intake. The findings provide insights into the immune predisposition to post-viral mold infections in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Paola de Candia, Giuseppe Matarese
Summary: This study reveals the role of folate-dependent one carbon metabolism enzyme MTHFD2 in CD4(+) T cell polarization and suggests its involvement in suppressing pro-inflammatory T cells while promoting regulatory T cells.
Article
Multidisciplinary Sciences
Anna Martner, Hanna Grauers Wiktorin, Andreas Tornell, Johan Ringlander, Mohammad Arabpour, Magnus Lindh, Martin Lagging, Staffan Nilsson, Kristoffer Hellstrand
Summary: This study identified two phases of T cell reactivity in COVID-19 patients: an early transient response and a durable cell memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Bahire Kalfaoglu, Jose Almeida-Santos, Chanidapa Adele Tye, Yorifumi Satou, Masahiro Ono
Summary: Research indicates that T-cells play crucial roles in the immunity to COVID-19, with dysregulation noted in severe cases. The impairment of FOXP3 induction in CD4(+) T-cells may lead to abnormal T-cell responses, while hyperactivated T-cells could potentially contribute to dysregulation and tissue destruction in severe COVID-19 patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Sonia Andre, Morgane Picard, Renaud Cezar, Florence Roux-Dalvai, Aurelie Alleaume-Butaux, Calaiselvy Soundaramourty, Andre Santa Cruz, Ana Mendes-Frias, Clarisse Gotti, Mickael Leclercq, Alexandre Nicolas, Alexandra Tauzin, Alexandre Carvalho, Carlos Capela, Jorge Pedrosa, Antonio Gil Castro, Lucy Kundura, Paul Loubet, Albert Sotto, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Geraud Claret, Sandra Duvnjak, Tu-Anh Tran, Gina Racine, Ouafa Zghidi-Abouzid, Pierre Nioche, Ricardo Silvestre, Arnaud Droit, Fabrizio Mammano, Pierre Corbeau, Jerome Estaquier
Summary: By comparing COVID-19 patients with healthy donors, the study found a strong correlation between T cell apoptosis and lymphopenia in severe cases. The plasma levels of soluble FasL (sFasL) and T cell surface expression of Fas/CD95 were positively correlated with T cell death and CD4 T cell counts. The study also identified modulations in the Bcl-2 family and demonstrated the potential of a pan-caspase inhibitor, Q-VD, to prevent T cell apoptosis and enhance Th1 transcripts.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Oncology
Tianyu Cao, Li Liu, Kelvin Kai-Wang To, Chun-Yu Lim, Runhong Zhou, Yue Ming, Ka-Yi Kwan, Sulan Yu, Chun-Yin Chan, Biao Zhou, Haode Huang, Yufei Mo, Zhenglong Du, Ruomei Gong, Luk-Tsz Yat, Ivan Fan-Ngai Hung, Anthony Raymond Tam, Wing-Kin To, Wai-Shing Leung, Thomas Shiu-Hong Chik, Owen Tak-Yin Tsang, Xiang Lin, You-qiang Song, Kwok-Yung Yuen, Zhiwei Chen
Summary: Background: Patients with COVID-19 display a wide range of disease severity and immune responses, and the mechanisms are unclear. Methods: We studied 137 patients infected with SARS-CoV-2, divided into mild and severe groups, and analyzed their immune and mitochondrial functions. Results: Severe patients showed increased activation of extrafollicular B cells and inflammation, while mild patients countered the disease through modulation of B cell mitochondrial function. Patients who received prior vaccination showed reduced B cell responses and milder disease. Conclusion: We identified an immune mechanism that controls disease severity, with implications for virus research, treatment, and vaccine development.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Kun Yang, Matthew Holt, Min Fan, Victor Lam, Yong Yang, Tuanzhu Ha, David L. Williams, Chuanfu Li, Xiaohui Wang
Summary: COVID-19, caused by SARS-CoV-2, results in global healthcare crises. Endothelial cell damage and lactate play important roles in COVID-19 pathogenesis and severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Mehrnoush Hadaddzadeh Shakiba, Ioanna Gemuend, Marc Beyer, Lorenzo Bonaguro
Summary: This mini-review examines the role of T cells in COVID-19, with a particular focus on the local immune response in the lung. The study discusses the reported T cell phenotypes in mild, moderate, and severe COVID-19, highlighting the protective and damaging roles of the T cell response in lung inflammation and pointing out some unanswered questions in the field.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Andrew C. Yang, Fabian Kern, Patricia M. Losada, Maayan R. Agam, Christina A. Maat, Georges P. Schmartz, Tobias Fehlmann, Julian A. Stein, Nicholas Schaum, Davis P. Lee, Kruti Calcuttawala, Ryan T. Vest, Daniela Berdnik, Nannan Lu, Oliver Hahn, David Gate, M. Windy McNerney, Divya Channappa, Inma Cobos, Nicole Ludwig, Walter J. Schulz-Schaeffer, Andreas Keller, Tony Wyss-Coray
Summary: This study found that patients with COVID-19 exhibited widespread cellular perturbations in the brain, including the relay of peripheral inflammation into the brain by choroid plexus barrier cells and infiltration of peripheral T cells. Additionally, COVID-19 affected synaptic signaling of upper-layer excitatory neurons linked to cognitive function.
Article
Microbiology
Elena Winheim, Linus Rinke, Konstantin Lutz, Anna Reischer, Alexandra Leutbecher, Lina Wolfram, Lisa Rausch, Jan Kranich, Paul R. Wratil, Johanna E. Huber, Dirk Baumjohann, Simon Rothenfusser, Benjamin Schubert, Anne Hilgendorff, Johannes C. Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Michael Von Bergwelt-Baildon, Konstantin Stark, Tobias Straub, Thomas Brocker, Oliver T. Keppler, Marion Subklewe, Anne B. Krug
Summary: COVID-19 patients exhibit reduced numbers and impaired function of DCs in the blood, correlated with disease severity and potential consequences for disease management and susceptibility to secondary infections.
Article
Clinical Neurology
Max Borsche, Andre Maertens, Philipp Hoermann, Theresa Brueckmann, Katja Lohmann, Sinem Tunc, Christine Klein, Karsten Hiller, Alexander Balck
Summary: This study investigates the differences in glucose metabolism between Parkinson's disease (PD) patients and healthy controls using advanced biochemical methods. The results show that glucose production pathways differ between idiopathic and PRKN mutation carriers, and are associated with diabetes. This study provides the first in vivo evidence for alterations in glucose metabolism in idiopathic PD.
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Lukas van de Sand, Peer Brass, Jonas Gregorius, Kevin Pattberg, Andrea Engler, Ulf Dittmer, Christian Taube, Stephan Brock, Marc Moritz Berger, Thorsten Brenner, Oliver Witzke, Adalbert Krawczyk
Summary: The COVID-19 pandemic has caused millions of deaths worldwide and remains a significant health issue. Infection by SARS-CoV-2 can be categorized into different phases, and hyperinflammation during the acute pneumonia phase is a major cause of disease progression and death. Early initiation of treatment is crucial for optimal patient care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Allergy
Sophia Bjoerkander, Paul Maier, Maura Kere, Simon Kebede Merid, Lorenz Wirth, Whitney Wiegel, Sandra Ekstroem, Inger Kull, Anna Bergstroem, Erik Melen, Jenny Mjoesberg, Christopher Andrew Tibbitt
Article
Medical Laboratory Technology
Gunnar Treff, Franziska Treff, Mahdi Sareban, Lisa M. Schiefer, Larissa Schaefer, Peter Schmidt, Josef Niebauer, Juergen M. Steinacker, Erik R. Swenson, Kai E. Swenson, Benjamin Mayer, Marc M. Berger
Summary: This study investigated the reliability and robustness of two widely used blood gas analyzers at high altitude. The results showed that compared to RAD, SIE had lower reliability at both 423m and 4559m, especially at 4559m where data reporting issues were more prevalent.
CLINICAL BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Sascha David, Christian Bode, Klaus Stahl
Summary: This is a clinical trial evaluating the impact of early therapeutic plasma exchange (TPE) on patients with septic shock. The researchers hypothesize that TPE can mitigate the maladaptive host response, thereby limiting organ dysfunction and improving survival. This study has the potential to change the current treatment standard for this condition.
Article
Medicine, General & Internal
Thilo von Groote, Melanie Meersch, Stefano Romagnoli, Marlies Ostermann, Javier Ripolles-Melchor, Antoine Guillaume Schneider, Wim Vandenberghe, Celine Monard, Silvia De Rosa, Lucia Cattin, Tim Rahmel, Michael Adamzik, Diego Parise, Angel Candela-Toha, Jan Gerrit Haaker, Ulrich Goebel, Alice Bernard, Nuttha Lumlertgul, Paula Fernandez-Valdes-Bango, Irene Romero Bhathal, A. Suarez-de-la-Rica, Jan Larmann, Gianluca Villa, Savino Spadaro, Hinnerk Wulf, Christian Arndt, Christian Putensen, Raquel Garcia-Alvarez, Timo Brandenburger, Antonio Siniscalchi, Richard Ellerkmann, Florian Espeter, Christian Porschen, Mahan Sadjadi, Khaschayar Saadat-Gilani, Raphael Weiss, Joachim Gerss, John Kellum, Alexander Zarbock
Summary: The BigpAK-2 trial aims to verify the effectiveness of the KDIGO guideline-based bundle in reducing the incidence and severity of AKI after surgery. It will recruit 1302 high-risk patients undergoing major surgery and randomize them into either a standard of care or the KDIGO-based AKI care bundle. The primary endpoint is the incidence of moderate or severe AKI within 72 hours after surgery.
Article
Immunology
Andreas Limmer, Andrea Engler, Simone Kattner, Jonas Gregorius, Kevin Thomas Pattberg, Rebecca Schulz, Jansje Schwab, Johannes Roth, Thomas Vogl, Adalbert Krawczyk, Oliver Witzke, Gennadiy Zelinskyy, Ulf Dittmer, Thorsten Brenner, Marc Moritz Berger
Summary: This study analyzed the immune and coagulation systems of 127 COVID-19 patients. The results showed that many severe patients exhibited signs of immunosuppression and a pronounced pro-coagulation phenotype. Therefore, individualized therapies are necessary for COVID-19 treatment.
Article
Critical Care Medicine
Endry H. T. Lim, Alexander P. J. Vlaar, Sanne de Bruin, Simon M. Rueckinger, Claus A. Thielert, Maria A. Habel, Renfeng Guo, Bruce E. Burnett, James E. Dickinson, Matthijs Brouwer, Niels Riedemann, Diederik van de Beek
Summary: A study has shown that vilobelimab, a medication targeting COVID-19, efficiently inhibits C5a, reducing mortality in critically ill patients without any immunogenicity associated with treatment.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Article
Medicine, General & Internal
Simone Kattner, Sivagurunathan Sutharsan, Marc Moritz Berger, Andreas Limmer, Lutz-Bernhard Jehn, Frank Herbstreit, Thorsten Brenner, Christian Taube, Francesco Bonella
Summary: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection has a variable disease course. KL-6 has the potential to be a candidate biomarker for predicting the severity and outcome of SARS-CoV-2 pneumonia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Critical Care Medicine
Klaus Stahl, Christian Bode, Sascha David
Article
Clinical Neurology
Felix Lehmann, Anna-Laura Potthoff, Valeri Borger, Muriel Heimann, Stefan Felix Ehrentraut, Christina Schaub, Christian Putensen, Johannes Weller, Christian Bode, Hartmut Vatter, Ulrich Herrlinger, Patrick Schuss, Niklas Schaefer, Matthias Schneider
Summary: Postoperative ICU monitoring is important for patient safety after resection of newly diagnosed glioblastoma. However, secondary unplanned ICU readmission is associated with poor survival in these patients, especially for those who received dexamethasone for more than 7 days before surgery. Precise patient selection and further scientific debate are crucial for patient safety in surgical treatment of glioblastoma.
NEUROSURGICAL REVIEW
(2023)
Review
Critical Care Medicine
Christian Bode, Sebastian Weis, Andrea Sauer, Pedro Wendel-Garcia, Sascha David
Summary: This article explores the immune dysregulation in sepsis and studies on treatment methods targeting the host response, as well as discusses the future prospects of precision medicine approaches in sepsis.
Article
Multidisciplinary Sciences
Marc Moritz Berger, Anika Huesing, Nicolai Niessen, Lisa Maria Schiefer, Michael Schneider, Peter Baertsch, Karl-Heinz Joeckel
Summary: The prevalence of acute mountain sickness (AMS) was assessed in mountaineers at different altitudes in the Western Alps. AMS was found to be common at altitudes >= 3650 m, and factors such as a history of AMS, higher altitude, lower degree of pre-acclimatization, and younger age were identified as risk factors. Slow ascent was weakly associated with AMS prevalence.
Article
Critical Care Medicine
Julia Leonhardt, Mirrin J. Dorresteijn, Sophie Neugebauer, Diana Mihaylov, Julia Kunze, Ignacio Rubio, Frank-Stephan Hohberger, Silke Leonhardt, Michael Kiehntopf, Klaus Stahl, Christian Bode, Sascha David, Frank A. D. T. G. Wagener, Peter Pickkers, Michael Bauer
Summary: The study found that circulating bile acids capable of inducing immunosuppression are present in septic shock patients, particularly in those with severe liver failure. Future research may need to explore whether modulating bile acid metabolism can improve the clinical course and outcome of sepsis in these patients.
Letter
Urology & Nephrology
Arturo Blazquez-Navarro, Lisa Mittmann, Constantin Joachim Thieme, Moritz Anft, Krystallenia Paniskaki, Adrian Doevelaar, Felix Sebastian Seibert, Bodo Hoelzer, Margarete Justine Konik, Marc Moritz Berger, Thorsten Brenner, Clemens Tempfer, Carsten Watzl, Toni Luise Meister, Stephanie Pfaender, Eike Steinmann, Sebastian Dolff, Ulf Dittmer, Oliver Witzke, Ulrik Stervbo, Toralf Roch, Michal Or-Guil, Timm Henning Westhoff, Nina Babel
JOURNAL OF NEPHROLOGY
(2023)