Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Psychiatry
Liwei Xing, Jinlong Xu, Yuanyuan Wei, Yang Chen, Haina Zhuang, Wei Tang, Shun Yu, Junbao Zhang, Guochen Yin, Ruirui Wang, Rong Zhao, Dongdong Qin
Summary: Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder that affects reproductive women, leading to various symptoms such as depression. The exact pathogenesis of depression in PCOS is still unclear, highlighting the need for further research to fully understand its mechanisms and treatment strategies.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Hongying Shan, Renxin Luo, Xuanying Guo, Rong Li, Zhenhong Ye, Tianliu Peng, Fenting Liu, Zi Yang
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women, which is associated with infertility, menstrual irregularities, endometrial hyperplasia, and obesity. The disease and its complications are closely related to local oxidative stress imbalance in the endometrium, affecting endometrial receptivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Review
Medicine, General & Internal
Junde Zhao, Xiaohui Sui, Qingyu Shi, Dan Su, Zhiheng Lin
Summary: This meta-analysis demonstrates the efficacy of antioxidant intervention in patients with PCOS, showing a significant effect on insulin resistance and lipid metabolism improvement. However, antioxidant intervention has no discernible impact on testosterone levels or body mass index. Omega-3 may be a more effective antioxidant intervention for PCOS.
Article
Endocrinology & Metabolism
Linyi Song, Jin Yu, Danying Zhang, Xi Li, Lu Chen, Zailong Cai, Chaoqin Yu
Summary: Excess androgen could damage the mitochondrial ultrastructure and function of ovarian granulosa cells in PCOS model rats by down-regulating the expression of NDUFB8 and ATP5j.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Sima Vaez, Kazem Parivr, Fardin Amidi, Nasim Hayati Rudbari, Ashraf Moini, Naser Amini
Summary: Quercetin intake has positive effects on PCOS patients, improving oocyte and embryo grade, increasing pregnancy rate, and reducing inflammation and LH parameters.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Huize Chen, Chujun Deng, Zeyu Meng, Shengxi Meng
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease characterized by menstrual disorders, infertility, and obesity, often accompanied by insulin resistance and metabolic disorders. Traditional Chinese medicine (TCM) has significant advantages in treating PCOS and can effectively reduce insulin levels, regulate lipid metabolism, and improve ovulation and pregnancy rates. This article reviews the efficacy and safety of Chinese herbs and other TCM treatments (such as acupuncture) for PCOS and its complications, as well as their impact on cellular endocrine and mechanisms, providing new clinical ideas for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Yang Ye, Cong-Cong Zhou, Hang-Qi Hu, Ii Fukuzawa, Hao-Lin Zhang
Summary: PCOS is a common endocrine and metabolic disorder among women, and current treatments have unsatisfactory efficacy. Acupuncture has shown significant effectiveness in regulating hormone levels, promoting ovulation, and attenuating insulin resistance. However, the mechanisms of acupuncture therapy in treating PCOS have not been comprehensively studied and evaluated.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Youngjae Ryu, Yong Jin Kim, Yoon Young Kim, Jungwoo Kim, Sung Woo Kim, Hoon Kim, Seung Yup Ku
Summary: This study successfully established a PCOS model in mice using STZ, with findings indicating that low doses of STZ can induce PCOS features without causing diabetes features. Different doses of STZ treatment had varying effects on body weight, blood glucose levels, and hormone levels in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Min Zhang, Chong Liu, Xiao-Qiong Yuan, Fei-Peng Cui, Yu Miao, Wen Yao, Dan-Yu Qin, Yan-Ling Deng, Pan-Pan Chen, Jia-Yue Zeng, Xiao-Ying Liu, Yang Wu, Cheng-Ru Li, Wen-Qing Lu, Yu-Feng Li, Qiang Zeng
Summary: Phthalate exposures are associated with increased prevalence of polycystic ovary (PCO) and polycystic ovary syndrome (PCOS).
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yue Che, Jie Yu, Yu-Shan Li, Yu-Chen Zhu, Tao Tao
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, affecting fertility and increasing the risk of various health problems. The current understanding of its pathogenesis is still incomplete, leading to difficulties in accurate diagnosis and personalized treatment. This article summarizes the current findings on the genetic, epigenetic, gut microbiota, brain responses, and metabolomics aspects of PCOS, highlighting the challenges in phenotyping and potential treatment approaches. It also discusses the intergenerational transmission of PCOS, providing insights for better management in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Ying-yi Luan, Lei Zhang, Yi-qiu Peng, Ying-ying Li, Rui-xia Liu, Cheng-hong Yin
Summary: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting females, characterized by chronic low-level inflammation, hormonal and immune dysregulation. It can lead to infertility, irregular menstruation, acne, hirsutism, and obesity.
CLINICA CHIMICA ACTA
(2022)
Article
Medicine, Research & Experimental
Leticia Morales-Ledesma, Angelica Trujillo Hernandez, Maria Isabel Ramirez, Gabriela Rosas, Rosa Linares
Summary: In both cyclic animals and EV-PCOS models, blocking VIP receptors reveals differential effects on ovarian function, with changes in steroidogenesis and ovarian catecholamine levels. The binding of VIP to its receptors regulates the responses of steroid hormones and catecholamines in the ovaries, highlighting the importance of VIP signaling in the pathophysiology of PCOS.
Article
Endocrinology & Metabolism
Claire Falzarano, Taylor Lofton, Adjoa Osei-Ntansah, Trinitee Oliver, Taylor Southward, Salim Stewart, Stanley Andrisse
Summary: Recent research has shown a high prevalence of nonalcoholic fatty liver disease (NAFLD) in women with polycystic ovary syndrome (PCOS). Women with normal weight can also develop NAFLD. The majority of studies focus on adult, premenopausal women and little attention has been given to young and adolescent women with NAFLD. Future research should include more diverse populations and study the contribution of excess androgens and insulin resistance to NAFLD risk in women with PCOS of varying weights, ages, and ethnicities.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Zeyan Li, Yueqing Tang, Shiqin Zhu, Dawei Li, Xiao Han, Gangli Gu, Naidong Xing, Juchao Ren, Zhaoxin Guo, Wei Jiao, Lei Yan, Zhonghua Xu, Wenhua Zhang
Article
Cell Biology
Qingqing Xu, Xiaofei Liu, Shiqin Zhu, Xuelei Hu, Huanmin Niu, Xiulei Zhang, Deyu Zhu, Effat Un Nesa, Keli Tian, Huiqing Yuan
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Review
Obstetrics & Gynecology
Shiqin Zhu, Bingqian Zhang, Xiao Jiang, Zeyan Li, Shigang Zhao, Linlin Cui, Zi-Jiang Chen
FERTILITY AND STERILITY
(2019)
Review
Clinical Neurology
Zeyan Li, Zhiqing Fang, Naidong Xing, Shiqin Zhu, Yidong Fan
SLEEP MEDICINE REVIEWS
(2019)
Article
Biochemistry & Molecular Biology
Shiqin Zhu, Zeyan Li, Linlin Cui, Yanli Ban, Peter C. K. Leung, Yan Li, Jinlong Ma
Summary: The study showed that integrin beta 1 mediates activin A-promoted trophoblast invasion through the ALK4-activated SMAD2/3-SMAD4 pathway. The predictive/diagnostic value of first-trimester maternal serum activin A for hypertensive disorders of pregnancy might be different in the IVF population.
Article
Cell Biology
Zeyan Li, Shuo Zhao, Shiqin Zhu, Yidong Fan
Summary: The study identified the miR-153-5p/AGO1 axis as crucial in the occurrence and progression of ccRCC tumors through the PI3K/Akt signaling pathway, providing potential therapeutic targets and prognostic biomarkers for patients with ccRCC.
CELL DEATH & DISEASE
(2021)
Review
Endocrinology & Metabolism
Shiqin Zhu, Zeyan Li, Cuiping Hu, Fengxuan Sun, Chunling Wang, Haitao Yuan, Yan Li
Summary: A systematic review and meta-analysis showed that women with PCOS have higher accumulations of visceral fat, abdominal subcutaneous fat, total body fat, trunk fat, and android fat compared to BMI-matched controls. However, when only studies using MRI or CT were considered, there were no significant differences in body fat distribution between PCOS and controls. Additionally, young and non-obese PCOS patients were found to be more likely to accumulate android fat.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Hongyu Zhao, Rufeng Chen, Dongxue Zheng, Feng Xiong, Fan Jia, Jinyuan Liu, Lili Zhang, Nana Zhang, Shiqin Zhu, Yongmei Liu, Linhua Zhao, Xinmin Liu
Summary: This study analyzed the characteristics of the intestinal microbiota in patients with PCOS-IR and explored the mechanism of modified Banxia Xiexin Decoction in treating PCOS-IR. The results showed that PCOS-IR model had an imbalance of intestinal microbiota and Genus Clostridium_sensu_stricto_1 might be the pivotal pathogenic bacteria. Modified Banxia Xiexin Decoction can improve PCOS-IR by regulating the balance of intestinal microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Xiangxin Lan, Ling Guo, Shiqin Zhu, Yongzhi Cao, Yue Niu, Shuwen Han, Zeyan Li, Yan Li, Junhao Yan
Summary: Pregnancy-induced hypertension (PIH) is a common pregnancy complication that affects the mother and fetus. The incidence of PIH is higher in pregnancies conceived after assisted reproductive technology (ART) than in spontaneous pregnancies. This study found that using a cytokine profile can effectively predict the risk of PIH in ART pregnancies, providing a basis for early intervention and prevention of PIH.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Ling Guo, Xiangxin Lan, Shanshan Liu, Lianqiong Xu, Shiqin Zhu, Hong-jin Zhao, Jinlai Meng, Yan Li
Summary: In this study, comprehensive bioinformatic analysis and logistic regression analysis were used to compare serum cytokine profiles between normotensive pregnant subjects and PE patients. The results showed significant differences in cytokine expressions between the two groups, which had significant correlations with the clinical features of PE. A panel of nine cytokines was identified for the diagnosis of PE, and a diagnostic model constructed from these cytokines showed better performance than any individual cytokine, providing a basis for developing early clinical diagnostic and therapeutic strategies for PE.
INFLAMMATION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Nana Zhang, Yan Liao, Hongyu Zhao, Tong Chen, Fan Jia, Yue Yu, Shiqin Zhu, Chaoying Wang, Wufan Zhang, Xinmin Liu
Summary: This study used a bidirectional two-sample Mendelian randomization (MR) design to investigate the causal association between polycystic ovary syndrome (PCOS) and 25-hydroxyvitamin D (25OHD) deficiency. The findings showed a negative association between genetically determined PCOS and 25OHD levels, but this causal effect disappeared when adjusting for obesity and insulin resistance. The study failed to find a substantial causal effect of 25OHD deficiency on the risk of PCOS. Further observational studies and clinical trials are needed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
