Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain

Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain

(2022) Nunzio Vicario et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist

(2020) Rita Turnaturi et al.   ACS Chemical Neuroscience

Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation

(2019) Lorella Pasquinucci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist

(2019) Lorella Pasquinucci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

(2019) Nunzio Vicario et al.   MOLECULAR NEUROBIOLOGY

Molecular Interplay Between the Sigma-1 Receptor, Steroids, and Ion Channels

(2019) Sara L. Morales-Lázaro et al.   Frontiers in Pharmacology

A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models

(2019) Wei Lei et al.   JOURNAL OF PAIN

Synthesis and Pharmacological Evaluation of Novel C-8 Substituted Tetrahydroquinolines as Balanced-Affinity Mu/Delta Opioid Ligands for the Treatment of Pain

(2018) Anthony F. Nastase et al.   ACS Chemical Neuroscience

Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review

(2018) Rita Turnaturi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain

(2018) Miguel Ortíz-Rentería et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(+)-and (−)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects

(2017) O. Prezzavento et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice

(2017) Magda Zammataro et al.   Frontiers in Pharmacology

Modeling Tanimoto Similarity Value Distributions and Predicting Search Results

(2016) Martin Vogt et al.   Molecular Informatics

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain

(2016) Nunzio Vicario et al.   Molecular Pain

S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund’s adjuvant models in mice

(2014) Georgia Gris et al.   BEHAVIOURAL PHARMACOLOGY

Topical nasal lysine aspirin in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis with nasal polyposis

(2014) Abhijeet Parikh et al.   Expert Review of Clinical Immunology

Selective sigma-1 receptor antagonists for the treatment of pain

(2014) Carmen Almansa et al.   Future Medicinal Chemistry

Sigma-1 receptor inhibition reverses acute inflammatory hyperalgesia in mice: role of peripheral sigma-1 receptors

(2014) M. A. Tejada et al.   PSYCHOPHARMACOLOGY

σ1 Receptors Are Involved in the Visceral Pain Induced by Intracolonic Administration of Capsaicin in Mice

(2013) Rafael González-Cano et al.   ANESTHESIOLOGY

Sigma 1 receptor: A new therapeutic target for pain

(2013) Daniel Zamanillo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation

(2013) Carmela Parenti et al.   INFLAMMATION RESEARCH

Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain

(2013) Alexander T. Podolsky et al.   LIFE SCIENCES

Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation

(2011) Dae-Hyun Roh et al.   BRITISH JOURNAL OF PHARMACOLOGY

A brief comparison of the pathophysiology of inflammatory versus neuropathic pain

(2011) Qinghao Xu et al.   Current Opinion in Anesthesiology

Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract

(2010) Carlos Sostres et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Synthesis and Resolution ofcis-(±)-Methyl (1R,2S/1S,2R)-2-[(4-Hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(±)-PPCC)]: New σ Receptor Ligands with Neuroprotective Effect

(2010) Orazio Prezzavento et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands

(2009) E. Cobos et al.   Current Neuropharmacology

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

(2009) Beatriz de la Puente et al.   PAIN

Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective sigma-1 ligands and sigma-1 knockout mice

(2009) José Manuel Entrena et al.   PAIN

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS

Intrathecal treatment with σ1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice

(2006) Hyun-Woo Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY