Pancreatic PCSK9 controls the organization of the β-cell secretory pathway via LDLR-cholesterol axis

Maturation of beta cells: lessons from in vivo and in vitro models

(2022) Tom Barsby et al.   DIABETOLOGIA

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

(2021) Lorenzo Da Dalt et al.   EUROPEAN HEART JOURNAL

Monoclonal Antibodies in the Management of Familial Hypercholesterolemia: Focus on PCSK9 and ANGPTL3 Inhibitors

(2021) Angela Pirillo et al.   Current Atherosclerosis Reports

Effects of Germline VHL Deficiency on Growth, Metabolism, and Mitochondria

(2020) Silverio Perrotta et al.   NEW ENGLAND JOURNAL OF MEDICINE

New Pharmacological Approaches to Target PCSK9

(2020) Alberico L. Catapano et al.   Current Atherosclerosis Reports

Verbascoside Protects Pancreatic β-Cells against ER-Stress

(2020) Alessandra Galli et al.   Biomedicines

Cholesterol metabolism, pancreatic β-cell function and diabetes

(2019) Carla Perego et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Long-Term Efficacy and Safety of Evolocumab in Patients With Hypercholesterolemia

(2019) Michael J. Koren et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

PCSK9 deficiency reduces insulin secretion and promotes glucose intolerance: the role of the low-density lipoprotein receptor

(2018) Lorenzo Da Dalt et al.   EUROPEAN HEART JOURNAL

Control of insulin granule formation and function by the ABC transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP

(2018) Syed Saad Hussain et al.   MOLECULAR BIOLOGY OF THE CELL

Pancreatic islet of Langerhans' cytoarchitecture and ultrastructure in normal glucose tolerance and in type 2 diabetes mellitus

(2018) Franco Folli et al.   DIABETES OBESITY & METABOLISM

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

(2018) James Cantley et al.   DIABETOLOGIA

The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism

(2017) Jonas Maczewsky et al.   ENDOCRINOLOGY

Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors: Shaping the future after the further cardiovascular outcomes research with PCSK9 inhibition in subjects with elevated risk (FOURIER) trial

(2017) Niki Katsiki et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

(2017) Amand F Schmidt et al.   Lancet Diabetes & Endocrinology

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions

(2017) Maria Dolores Perez Carrion et al.   Scientific Reports

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes

(2016) Brian A. Ference et al.   NEW ENGLAND JOURNAL OF MEDICINE

PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse LiverSignificance

(2015) Annie Demers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Weaning Triggers a Maturation Step of Pancreatic β Cells

(2015) Miri Stolovich-Rain et al.   DEVELOPMENTAL CELL

Role of cholesterol in SNARE-mediated trafficking on intracellular membranes

(2015) C. Enrich et al.   JOURNAL OF CELL SCIENCE

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning

(2015) Cécile Jacovetti et al.   Nature Communications

Role of Epac2A/Rap1 Signaling in Interplay Between Incretin and Sulfonylurea in Insulin Secretion

(2014) Harumi Takahashi et al.   DIABETES

MicroRNA-7a regulates pancreatic β cell function

(2014) Mathieu Latreille et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting PCSK9 for Hypercholesterolemia

(2013) Giuseppe Danilo Norata et al.   Annual Review of Pharmacology and Toxicology

Two ABCB4 point mutations of strategic NBD-motifs do not prevent protein targeting to the plasma membrane but promote MDR3 dysfunction

(2013) Dario Degiorgio et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired  -Cell Function

(2012) J. K. Kruit et al.   DIABETES

Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking

(2012) Jonathan S. Bogan et al.   TRAFFIC

Cholesterol-enriched membrane rafts and insulin secretion

(2012) Ronald Dirkx Jr et al.   Journal of Diabetes Investigation

The Glial Glutamate Transporter 1 (GLT1) Is Expressed by Pancreatic β-Cells and Prevents Glutamate-induced β-Cell Death

(2011) Eliana S. Di Cairano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proprotein convertase subtilisin/kexin type 9 (PCSK9): From structure–function relation to therapeutic inhibition

(2011) G. Tibolla et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

The Surface Density of the Glutamate Transporter EAAC1 is Controlled by Interactions with PDZK1 and AP2 Adaptor Complexes

(2010) Anna D’ Amico et al.   TRAFFIC

PCSK9 is expressed in pancreatic δ-cells and does not alter insulin secretion

(2009) Cédric Langhi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disproportionate Hyperproinsulinemia, β-Cell Restricted Prohormone Convertase 2 Deficiency, and Cell Cycle Inhibitors Expression by Human Islets Transplanted into Athymic Nude Mice: Insights into Nonimmune-Mediated Mechanisms of Delayed Islet Graft Failure

(2009) Alberto M. Davalli et al.   CELL TRANSPLANTATION

Cholesterol metabolism and pancreatic β-cell function

(2009) Michelle Fryirs et al.   CURRENT OPINION IN LIPIDOLOGY

Pdx1 and other factors that regulate pancreatic β-cell survival

(2009) K. Fujimoto et al.   DIABETES OBESITY & METABOLISM

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities

(2009) Majambu Mbikay et al.   FEBS LETTERS

Cholesterol in islet dysfunction and type 2 diabetes

(2008) Liam R. Brunham et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells

(2007) Michael J. MacDonald et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS