Article
Immunology
Si-Hang Wang, Ying Shan, Si-Zhe Li, Ya-Gang Zuo
Summary: This case series suggests that using the anti-IL-4 receptor & alpha; antibody Dupilumab may be an effective treatment for moderate to severe BP patients. Impressive efficacy and safety profiles were observed after 1 year of follow-up.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Katie A. Dunleavy, Darrell S. Pardi
Summary: This article summarizes and synthesizes current FDA-approved biological therapy for Crohn's disease and examines the positioning of medical therapy as emerging biologics break onto the market.
GASTROENTEROLOGY REPORT
(2022)
Article
Medicine, Research & Experimental
Michael J. Stewart, Talat Bessissow, James Gregor, Maureen Hazel, Tracy S. H. In, Kinda Karra, Dorota Dajnowiec, Martin Williamson, Bernie Sattin
Summary: In this study comparing UC patients receiving golimumab or adalimumab, no significant differences were observed in treatment patterns or healthcare resource utilization outcomes.
ADVANCES IN THERAPY
(2021)
Article
Gastroenterology & Hepatology
Laura E. Targownik, Charles N. Bernstein, Eric Benchimol, Gilaad G. Kaplan, Harminder Singh, Aruni Tennakoon, Zoann Nugent, Stephanie B. Coward, M. Ellen Kuenzig, Sanjay K. Murthy
Summary: Early administration of anti-TNF therapy is associated with reduced healthcare resource utilization in CD, but not in UC.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
N. Nimalan A. Jeganathan, Walter A. Koltun
Summary: Rates of anastomotic leak following intestinal resections in inflammatory bowel disease are significantly influenced by clinical characteristics such as low serum albumin, preoperative abscess, reoperative abdominal surgery, and steroid use. While the literature may be conflicting, common themes suggest factors like biologic therapy, immunomodulator use, and method of anastomosis do not increase anastomotic-related complications. Attention to identifying, optimizing, and reducing known risks is crucial in achieving a low rate of anastomotic leakage in colorectal surgery.
CLINICS IN COLON AND RECTAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Neeraj Narula, Emily C. L. Wong, Raed AlRamdan, Hasan Bualbanat, John K. Marshall, A. Hillary Steinhart, Tomer Greener, Mark S. Silverberg
Summary: The study demonstrates that higher maintenance doses of adalimumab are more effective in prolonging time to treatment failure in CD patients who failed anti-TNF therapy, compared with standard doses. Adverse events did not differ significantly between the two dose regimens.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Evi Zhuleku, Beatriz Antolin-Fontes, Andras Borsi, Riikka Nissinen, Ivana Bravata, Jennifer Norma Barthelmes, Manuela Le Bars, Jennifer Lee, Alun Passey, Ulf Maywald, Barthold Deiters, Bernd Bokemeyer, Thomas Wilke, Marco Ghiani
Summary: This study aims to investigate the outcomes of CD patients who switch to different types of biologics compared to switching to another anti-TNF after initial anti-TNF therapy failure. The results suggest that CD patients achieve more favorable outcomes when switching to biologics outside the anti-TNF class.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Cell & Tissue Engineering
Min Young Park, Yong Sik Yoon, Jong Lyul Lee, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang, Chang Sik Yu
Summary: This study compared the closure rates of perianal fistulas in Crohn's disease patients treated with anti-tumor necrosis factor (TNF) agents or autologous adipose tissue-derived stem cell (auto-ASC) transplantation. The results showed that the closure rate was significantly faster in the auto-ASC transplantation group.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Caiguang Liu, Na Li, Shukai Zhan, Zhenyi Tian, Dongxuan Wu, Tong Li, Zhirong Zeng, Xiaojun Zhuang
Summary: The results of this meta-analysis demonstrate that biologics are more effective than non-biological treatments in preventing postoperative recurrence in patients with Crohn's disease, with anti-TNFα agents showing superiority in preventing endoscopic recurrence. Additionally, infliximab and adalimumab have similar efficacy in preventing postoperative recurrence.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2021)
Article
Medicine, Research & Experimental
Salma Merhaben, Shema Ayadi, Monia Tangour, Nadia Boujelbene, Rayfa Ghariani, Leila Mouelhi, Fathi Merhaben
Summary: Primary hepatic lymphoma is a rare variant of non-Hodgkin's lymphoma, with an incidence of 0.016% among all non-Hodgkin lymphomas. The most common histologic subtype is large diffuse B-cell lymphoma. The pathogenesis is not clearly established, but immunosuppressive therapy has been suggested as a risk factor. We present an intriguing case study of a 23-year-old male patient with Crohn's Disease, who had been receiving a combination therapy of thiopurine and anti-TNF for 6 years and was diagnosed with primary hepatic diffuse large B-cell lymphoma.
Article
Gastroenterology & Hepatology
Pauline Riviere, Caitlyn Kanters, Gauthier Pellet, Alexander Ni, Marianne Hupe, Nesrine Aboulhamid, Florian Poullenot, Alain Bitton, Frank Zerbib, Peter L. Lakatos, Waqqas Afif, David Laharie, Talat Bessissow
Summary: This study aimed to compare the efficacy of anti-tumor necrosis factor agents and ustekinumab in patients with Crohn's disease. The results showed that anti-tumor necrosis factor agents as first-line biological therapy were associated with higher response rates at 3 months compared to ustekinumab.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Lorant Gonczi, Laszlo Lakatos, Zsuzsanna Kurti, Petra Golovics, Tunde Pandur, Gyula David, Zsuzsanna Erdelyi, Istvan Szita, Peter L. Lakatos
Summary: This study conducted a prospective study on Crohn's disease patients in Hungary and found a high incidence rate, reflecting the era of biologic therapy in treatment strategies. The progression of disease behavior was low and long-term surgery rates had decreased.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Zsuzsanna Kurti, Lorant Gonczi, Laszlo Lakatos, Petra Golovics, Tunde Pandur, Gyula David, Zsuzsanna Erdelyi, Istvan Szita, Peter L. Lakatos
Summary: This study analyzed the incidence, prevalence, disease phenotype, treatment strategy, disease course, and colectomy rates of ulcerative colitis (UC) patients in Hungary from 2007 to 2018. The results showed a high incidence of UC in Hungary, similar to high-incidence areas in Western Europe. Treatment strategies were consistent with the biological era, and the probability of disease progression and colectomy rates were lower compared to data from Western European centers.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Anesthesiology
Jakob Oxlund, Torben Knudsen, Helle Leonthin, Palle Toft, Poul Jorgen Jennum
Summary: Sleep deprivation in the intensive care unit (ICU) is common and linked to delirium and higher mortality. Polysomnography (PSG) is the gold standard for sleep evaluation, but practical limitations lead to the use of subjective sleep assessment (SSA) in many ICUs. However, the agreement between SSA and PSG remains unclear, and SSA may overestimate total sleep time (TST). This study found that the agreement between SSA and PSG was low in mechanically ventilated ICU patients, and there was a significant overestimation of TST when using SSA.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Editorial Material
Gastroenterology & Hepatology
C. Vigano, G. M. Sampietro
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Piotr Eder, Bram Verstock, Emma Culver, Gabriele Dragoni, Lea Isabell Kredel, Joanna Wypych, Ana Garcia Garcia de Paredes, Magdalena Kaniewska, Haim Leibovitzh, Triana Lobaton, Marie Truyens, Grzegorz Oracz, Davide Giuseppe Ribaldone, Teresa Starzynska, Abdenor Badaoui, Jean-Francois Rahier, Cristina Bezzio, Peter Bossuyt, Katherine Falloon, Daniela Pugliese, Catherine Frakes Vozzo, Tine Jess, Lone Larsen, Soren Schou Olensen, Partha Pal, Maria Chaparro, Dikla Dror, Pierre Ellul, Iga Gromny, Maria Janiak, Katarzyna Maciejewska, Noam Peleg, Ariella Bar-Gil Shitrit, Lukasz Szwed, Renata Talar-Wojnarowska, Yifat Snir, Roni Weisshof, Eran Zittan, Izabela Miechowicz, Idan Goren
Summary: This study investigated the long-term outcomes of autoimmune pancreatitis (AIP) and inflammatory bowel disease (IBD) in patients with coexisting AIP-IBD, as well as the predictors of complicated AIP course. The majority of patients had type 2 AIP and colonic IBD, and the AIP course was relatively benign with favorable prognosis, but a quarter of the patients developed pancreatic complications. Age, family history, and CD were identified as potential predictors of uncomplicated AIP course.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Clinical Neurology
Johanna M. Ospel, Mahmood Mirza, Frederic Clarencon, Adnan Siddiqui, Karen Doyle, Arturo Consoli, Maxim Mokin, Teresa Ullberg, Osama Zaidat, Romain Bourcier, Zsolt Kulcsar, Matthew J. Gounis, David S. Liebeskind, Jens Fiehler, Ana Paula Narata, Marc Ribo, Tudor Jovin, Nobuyuki Sakai, Ansaar Rai, Ray McCarthy, Franziska Dorn, Tommy Andersson, Charles B. L. M. Majoie, Ricardo Hanel, Ashutosh Jadhav, Christian Riedel, Angel Chamorro, Waleed Brinjikji, Vincent Costalat, Simon F. DeMeyer, Raul G. Nogueira, Christophe Cognard, Joan Montaner, Thomas W. Leung, Carlos Molina, Heleen van Beusekom, Antoni Davalos, John Weisel, Rene Chapot, Markus Moehlenbruch, Patrick Brouwer
Summary: This study used the DELPHI technique to investigate the features of challenging clots in mechanical thrombectomy for acute stroke. After three rounds of DELPHI survey, it was found that white-colored clots, calcified clots, stiff clots, sticky/adherent clots, hard clots, difficult to pass clots, and clots that are resistant to pulling are considered challenging clots.
CLINICAL NEURORADIOLOGY
(2023)
Article
Nursing
Janni Petersen Fallesen, Marie Louise Krogh, Lisbeth Rosenbek Minet, Mette Maria Skjoth, Torben Knudsen, Jens Kjeldsen
Summary: This study aims to explore the communication experiences between patients with Inflammatory bowel disease and healthcare professionals in outpatient clinics, and to identify the important factors such as easy access, predictability of follow-up appointments, privacy, and quality of time with healthcare professionals.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Medicine, General & Internal
Cristina Rubin de Celix, Javier Martin-de-Carpi, Gemma Pujol-Muncunill, Laura Maria Palomino, Marta Velasco Rodriguez-Belvis, Rafael Martin-Masot, Victor Manuel Navas-Lopez, Elena Ricart, Maria Jose Casanova, Alejandro Rodriguez-Martinez, Eduardo Leo-Carnerero, Alba Alcaraz, Miriam Manosa, Vicent Hernandez, Maria Consuelo Cobelas Cobelas, Cesar Sanchez, Luis Menchen, Francisco Mesonero, Manuel Barreiro-De Acosta, Nazareth Martinon-Torres, Coral Tejido Sandoval, Alicia Rendo Vazquez, Pilar Corsino, Raquel Vicente, Alejandro Hernandez-Camba, Jose Ramon Alberto Alonso, I. Alonso-Abreu, Ana Maria Castro Millan, Laia Peries Reverter, Beatriz Castro, Estela Fernandez-Salgado, M. Mercedes Busto Cuinas, Jose Manuel Benitez, Lucia Madero, Fernando Clemente, Sabino Riestra, Santiago Jimenez-Trevino, Maia Bosca-Watts, Elena Crehua-Gaudiza, Marta Calvo Moya, Jose Maria Huguet, Ester-Maria Largo-Blanco, Leticia Gonzalez Vives, Rocio Plaza, Ivan Guerra, Josefa Barrio, Laura Escartin, Erika Alfambra, Noelia Cruz, M. Carmen Munoz, Maria Guadalupe Munoz Pino, Manuel Van Domselaar, Belen Botella, David Monfort Miquel, M. Carmen Rodriguez Grau, Agustin De La Mano, Yolanda Ber, Maria Calvo Iniguez, Teresa de Jesus Martinez-Perez, Maria Chaparro, Javier P. Gisbert
Summary: This study evaluated the impact of transition on inflammatory bowel disease (IBD) outcomes and found that transition care programs improve patient outcomes after the transfer from pediatric to adult IBD units. Active IBD at the time of transfer impairs outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Molly S. George, Jenifer Sanchez, Christina Rollings, David Fear, Peter Irving, Linda V. Sinclair, Anna Schurich
Summary: Long-term T cell dysregulation following COVID-19 disease is associated with disease severity and long-covid symptoms. Alterations in cellular origin and protein content of extracellular vesicles (EV) during COVID-19 convalescence are linked to initial disease severity. EV derived from convalescent donors can affect the function and metabolic rewiring of CD4 and CD8 T cells, with immune-suppressive properties observed in mild cases.
Article
Medicine, General & Internal
Lena Royston, Stephane Isnard, Carolina A. Berini, Simeng Bu, Peter L. Lakatos, Talat Bessissow, Nicolas Chomont, Marina Klein, Bertrand Lebouche, Alexandra de Pokomandy, Nadine Kronfli, Cecilia T. Costiniuk, Rejean Thomas, Cecile Tremblay, Guy Boivin, Jean-Pierre Routy
Summary: This study aims to assess whether letermovir, a novel anti-CMV drug, can inhibit CMV subclinical replication in HIV patients receiving ART, and subsequently reduce CMV-associated gut damage and inflammation. The study will conduct a 14-week open-label, randomized, controlled clinical trial with 60 CMV-seropositive ART-treated HIV patients. The effects of letermovir on gut damage, microbial translocation, inflammation, and HIV reservoir size will be evaluated.
Meeting Abstract
Gastroenterology & Hepatology
P. Bacsur, P. Wetwittayakhlang, T. Resal, M. Rutka, T. Bessissow, W. Atif, A. Balint, A. Fabian, R. Bor, Z. Szepes, K. Farkas, P. L. Lakatos, T. Molnar
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
J. Burisch, M. Zhao, S. Odes, P. De Cruz, S. Vermeire, C. N. Bernstein, G. G. Kaplan, D. Duricova, D. Greenberg, H. O. Melberg, M. Watanabe, H. S. Ahn, L. Targownik, V. E. H. Pittet, V. Annese, K. Park, K. H. Konstantinos H, M. L. Hoivik, Z. Krznaric, M. Chaparro, E. V. Loftus, P. L. Lakatos, J. P. Gisbert, W. Bemelman, B. Moum, R. B. Gearry, M. D. Kappelman, A. Hart, M. Pierik, J. Andrews, S. Ng, R. D'Inca, P. Munkholm
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
G. D'Haens, P. Bossuyt, F. Baert, T. Molnar, E. Clasquin, M. Lowenberg, N. Montazeri, H. Peeters, G. Lambrecht, S. Vermeire
JOURNAL OF CROHNS & COLITIS
(2023)
