Article
Gastroenterology & Hepatology
Aaron B. Parrish, Nicole E. Lopez, Adam Truong, Karen Zaghiyan, Gil Y. Melmed, Dermot P. B. McGovern, Christina Ha, Gaurav Syal, Nirupama Bonthala, Anjali Jain, Carol J. Landers, Stephan R. Targan, Phillip Fleshner
Summary: This study found that serum vedolizumab levels do not affect postoperative morbidity in patients with IBD, but may help reduce the incidence of postoperative ileus in patients with Crohn's disease.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Surgery
Henrique A. Lima, Zorays Moazzam, Selamawit Woldesenbet, Laura Alaimo, Yutaka Endo, Muhammad M. Munir, Chanza F. Shaikh, Vivian Resende, Timothy M. Pawlik
Summary: This study aimed to investigate the association between prolonged county-level poverty and postoperative outcomes. The results showed that prolonged poverty was associated with serious postoperative complications, 30-day readmission, 30-day mortality, and higher healthcare expenditures. The effects of poverty on outcomes were mediated by various socioeconomic factors, and minority patients were disproportionately affected.
Article
Surgery
Michael R. Mathis, Steven Yule, Xiaoting Wu, Roger D. Dias, Allison M. Janda, Sarah L. Krein, Milisa Manojlovich, Matthew D. Caldwell, Korana Stakich-Alpirez, Min Zhang, Jason Corso, Nathan Louis, Tongbo Xu, Jeremy Wolverton, Francis D. Pagani, Donald S. Likosky
Summary: Team familiarity is associated with cardiac surgery outcomes, with high familiarity reducing cardiopulmonary bypass duration and improving efficiency without significantly impacting major postoperative complications and mortality rates.
Article
Medicine, General & Internal
Carlos Riveros, Sanjana Ranganathan, Yash B. Shah, Emily Huang, Jiaqiong Xu, Michael Geng, Zachary Melchiode, Siqi Hu, Brian J. Miles, Nestor Esnaola, Dharam Kaushik, Angela Jerath, Christopher J. D. Wallis, Raj Satkunasivam
Summary: The discharge destination is associated with the 30-day outcomes of surgical patients, and non-home discharge is more closely related to adverse outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yan Guangyu, Lou Jingfeng, Liu Xing, Yuan Hong, Lu Yao
Summary: Postoperative AKI in hypertensive patients undergoing noncardiac surgery is associated with a significantly higher risk of fatal stroke, fatal MI, and all-cause mortality within 5 years. The risk is even higher in patients receiving ACEI/ARB and CCB perioperatively.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Surgery
Y. Wan, Akshaykumar Patel, C. Achary, R. Hewson, M. Phull, R. M. Pearse
Summary: Postoperative infection is a common complication after elective surgery, increasing the risk of death and length of hospital stay. Important treatments include the use of antimicrobials and admission to critical care.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Albane Giger, Clement Schneider, Sandrine Marguerite, Dharmesh Ramlugun, Anne-Lise Maechel, Olivier Collange, Paul-Michel Mertes, Jean-Philippe Mazzucotelli, Michel Kindo
Summary: This study analyzed the impact of a systematic standardized enhanced recovery after cardiac surgery (ERACS) program for patients undergoing surgical aortic valve replacement (SAVR). The ERACS program significantly improved postoperative outcomes, including reduced troponin I peak level, increased left ventricular ejection fraction, decreased incidence of complications such as pneumonia, delirium, and acute renal failure, decreased blood transfusion rate, and shorter intensive care unit stay.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Pediatrics
Robert Brock, Angel Chu, Shengjie Lu, Mary Elizabeth Brindle, Ranjani Somayaji
Summary: In this study, socio-demographic risk factors for complications following pediatric gastrointestinal surgery were identified. Male sex, young age, African American and Native American race, and treatment in a rural hospital were associated with a higher risk of postoperative complications. The study also found that patients with complications have a longer length of stay and higher hospitalization costs compared to those without complications.
Article
Surgery
Alessandro Paro, J. Madison Hyer, Adrian Diaz, Diamantis Tsilimigras, Timothy M. Pawlik
Summary: This study identified distinct profiles of social vulnerability among Medicare beneficiaries and found an association between these profiles and postoperative outcomes. Patients with higher overall vulnerability had worse postoperative outcomes, and outcomes varied across different vulnerability profiles, even among patients with similar overall vulnerability scores.
Article
Anesthesiology
Francois Martin Carrier, Eva Amzallag, Vincent Lecluyse, Genevieve Cote, Etienne J. Couture, Frederick D'Aragon, Stanislas Kandelman, Alexis F. Turgeon, Alain Deschamps, Roy Nitulescu, Codjo Djignefa Djade, Martin Girard, Pierre Beaulieu, Philippe Richebe
Summary: This study found a high 30-day postoperative mortality rate (15.9%) among COVID-19 patients, with frequent pulmonary complications. Although only a small number of surgeries were performed on COVID-19 patients, the pandemic had a significant impact on overall surgical activity volume.
BMC ANESTHESIOLOGY
(2021)
Article
Surgery
Nina S. Cohen, Jiselle M. Bock, Addison K. May
Summary: Surgical site infections are a significant cause of illness and death. There is strong evidence supporting several preventive measures, but their effective implementation is not optimal. It is crucial to identify high-risk patients and avoid pitfalls in diagnosing surgical site infections, especially in emergency surgery patients with physiological disorders. Maintaining a high level of suspicion after surgery is critical in identifying patients with surgical site infections and preventing failure to rescue.
Article
Multidisciplinary Sciences
Hong Fu, Jiang Zheng, Jingyi Lai, Victor W. Xia, Kaiping He, Dingyuan Du
Summary: This study aimed to identify factors associated with serious postoperative outcomes in patients aged 90 years and above. The results showed that factors such as high ASA classification, emergency surgery, and comorbidities like chronic heart failure and chronic kidney disease were independent risk factors for adverse postoperative outcomes.
Article
Oncology
Young Ho Yang, Seong Yong Park, Ha Eun Kim, Byung Jo Park, Chang Young Lee, Jin Gu Lee, Dae Joon Kim, Hyo Chae Paik
Summary: The study investigated the results of postoperative bronchopleural fistula repair and identified mechanical ventilation as a significant adverse factor for its success. The use of omental flap tended to have a higher success rate compared to muscle flap group.
Article
Medicine, General & Internal
Giuseppe Frieri, Marco Valvano, Sara Frassino, Susanna Faenza, Nicola Cesaro, Gianfranco Amicucci, Rosa Manetta, Angelo Viscido, Giovanni Latella
Summary: About 50% of CD patients undergo intestinal resection, and 40% of those experience postoperative recurrence within 5 years. This case series aimed to evaluate the incidence of recurrence in CD patients with high risk and prophylactic treatment using Vedolizumab. Magnetic resonance enterography was used to assess the patients after surgical resection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Surgery
Ashrafun Nessa, Shafaque Shaikh, Mairi Fuller, Yazan A. Masannat, Stavroula L. Kastora
Summary: Robotic nipple-sparing mastectomy has the potential to reduce the risk of nipple necrosis, but it comes with longer operating time and length of stay compared to conventional mastectomy.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Chung Sang Tse, Gil Y. Melmed, Corey A. Siegel, Chien-Hsiang Weng, Samir A. Shah, S. Alandra Weaver, Brant J. Oliver, Glyn Elwyn, Welmoed K. van Deen
Summary: Health confidence has bidirectional temporal correlations with inflammatory bowel disease activity, where low health confidence is associated with higher risks for future disease activity.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Silvio Danese, Marc Ferrante, Brian G. Feagan, Laurent Peyrin-Biroulet, Toshifumi Hibi, William J. Sandborn, Stefan Schreiber, Timothy Ritter, Edward V. Loftus, Gerhard Rogler, Alessandra Oortwijn, Chohee Yun, Franck-Olivier Le Brun, Jason Dinoso, Jeremy Hsieh, Severine Vermeire
Summary: This study evaluated the efficacy and sustainability of filgotinib in treating moderately to severely active ulcerative colitis (UC) patients using the Mayo Clinic Score (pMCS) and patient-reported subscores. The results showed that treatment with filgotinib improved UC symptoms within 7 days and a higher proportion of patients achieved clinical remission at weeks 10 and 58.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Quazim A. Alayo, Edward Loftus Jr, Andres Yarur, David Alvarado, Matthew A. Ciorba, Lisa de las Fuentes, Parakkal Deepak
Summary: Population-based studies have shown that patients with inflammatory bowel disease (IBD) have an increased risk of acute arterial events (AAEs). This study aimed to assess the risk of incident AAEs and premature AAEs in participants with IBD in the UK Biobank (UKB) and found that IBD patients had a higher risk of AAEs and premature AAEs compared to non-IBD controls.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zeinab Bakhshi, Siddhant Yadav, W. Scott Harmsen, Jithinraj Edakkanambeth Varayil, Kevin A. Karls, William J. Tremaine, Edward V. Loftus
Summary: Risk factors for osteonecrosis in inflammatory bowel disease patients include corticosteroid use, estrogen use, arthropathy, and osteoporosis.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Kendra J. Kamp, Stephen E. Hawes, Chung Sang Tse, Siddharth Singh, Nhu Dang, Ridhima Oberai, S. Alandra Weaver, Gil Y. Melmed, Corey A. Siegel, Welmoed K. van Deen
Summary: There is discordance between patients' self-reported remission and remission defined based on patient-reported outcomes in patients with inflammatory bowel disease (IBD), with disease duration and health confidence being associated factors.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Edward V. Loftus, Severine Vermeire, Brian G. Feagan, Franck-Olivier Le Brun, Alessandra Oortwijn, Ulrik Moerch, William J. Sandborn, Toshifumi Hibi
Summary: In patients with ulcerative colitis, the study found that 200 mg of filgotinib can reduce the use of corticosteroids and maintain corticosteroid-free clinical remission. Moreover, compared to other medications, filgotinib demonstrated better outcomes in patients who had not previously used biologic agents.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Daniela Guerrero Vinsard, David H. Bruining, James E. East, Derek Ebner, Sunanda V. Kane, John B. Kisiel, Jonathan A. Leighton, Ryan J. Lennon, Edward V. Loftus, Talha Malik, Michael Picco, Laura Raffals, Guilherme P. Ramos, Priscila Santiago, Nayantara Coelho-Prabhu
Summary: This study aimed to determine the interobserver agreement and accuracy of endoscopists for pathology prediction of visible lesions in inflammatory bowel disease (IBD) using the modified Paris classification. The results showed very low agreement for both the Paris and modified Paris classifications, as well as low accuracy for pathology prediction.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Medicine, Research & Experimental
Edward V. Loftus, Jenny Griffith, Ezequiel Neimark, Alexandra Song, Kori Wallace, Sujani Nannapaneni, Ji Zhou, Rachel Byrne, Kristina Kligys, Yinuo Pang, Xiaomei Liao, Jasmina Kalabic, Marla Dubinsky
Summary: In patients with moderate to severe Crohn's disease (CD), intravenous induction and subcutaneous maintenance dosing with risankizumab was effective and well tolerated. Self-administration of risankizumab using an on-body injector (OBI) may improve treatment adherence and convenience for patients.
ADVANCES IN THERAPY
(2023)
Article
Gastroenterology & Hepatology
Jessica A. Ulrich, Nawras W. Habash, Yasmine A. Ismail, William J. Tremaine, Amy L. Weaver, Joseph A. Murray, Edward V. Loftus Jr, Imad Absah
Summary: This study compared the effectiveness of HBV vaccination for patients with IBD/CD and matched referents, and found that routine testing of anti-HBs titers may not be necessary for fully vaccinated patients with IBD/CD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Reena Khanna, Christopher Ma, Malcolm Hogan, Guangyong Zou, Talat Bessissow, Brian Bressler, Jean-Frederic Colombel, Silvio Danese, Marco Daperno, James E. East, Lawrence Hookey, Edward V. Loftus Jr, John W. D. Mcdonald, Remo Panaccione, Laurent Peyrin-Biroulet, Matt Rutter, Bruce E. Sands, Serverine Vermerire, Julie Remillard, Stefanie C. McFarlane, William J. Sandborn, Geert R. D'Haens, Brian G. Feagan, Vipul Jairath
Summary: This study aimed to define appropriate items for evaluating endoscopic activity and conventions for consistent endoscopic scoring rules in Crohn's disease (CD). The results showed that ulcers, narrowing, and healing should be included in the endoscopic scoring, while scarring and inflammatory polyps should not. The optimal method for defining ulcer depth remains uncertain. This study identified priorities for future research to develop a more representative endoscopic index for CD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Chung Sang Tse, Hang P. P. Nguyen, Siddharth Singh, Parambir S. S. Dulai, Jennifer Neill, Helen Le, Mark Valasek, Thierry Dervieux, Angelina E. E. Collins, Brigid Sweeney Boland
Summary: There is discordance between gastrointestinal symptoms and endoscopic inflammation in patients with ulcerative colitis, and the correlations between symptoms and endoscopic and histologic mucosal healing remain unknown.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Chung Sang Tse, Chien-Hsiang Weng, Michelle Kwon, Courtney Benjamin Wolk, Lily A. Brown, Kanika Malani, Samir A. Shah, Sean D. Fine
Summary: An analysis of over 260 million emergency department visits in the United States from 2007 to 2017 shows that inflammatory bowel disease patients have a more than 10-fold increased risk of suicide deaths, self-harm, substance use, and psychiatric disorders, although the overall self-harm rates are low (less than 1% of all-cause inflammatory bowel disease emergency department visits; total of 56 suicide deaths).
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Siri A. Urquhart, Bryce P. Comstock, Mauricio F. Jin, Courtney N. Day, John E. Eaton, William S. Harmsen, Laura E. Raffals, Edward Loftus, Nayantara Coelho-Prabhu
Summary: The incidence of pouch neoplasia in inflammatory bowel disease patients who have undergone ileal pouch-anal anastomosis (IPAA) is low. Extensive colitis, primary sclerosing cholangitis, and backwash ileitis prior to IPAA as well as rectal dysplasia at time of IPAA raise the risk of pouch neoplasia significantly.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Dermatology
Afsaneh Alavi, Edward V. Loftus Jr
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Chung Sang Tse, Melissa G. Hunt, Lily A. Brown, James D. Lewis
Summary: The diagnosis of IBD brings about significant changes in the lives of most adults. Despite advancements in treatment options, medical and surgical intervention alone may not be enough to completely restore health and prevent long-term disability due to the incurable nature of IBD.
INFLAMMATORY BOWEL DISEASES
(2023)