期刊
MARINE DRUGS
卷 20, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/md20080486
关键词
marine-derived fungus; Eutypella scoparia; polyketide; absolute configuration; anti-inflammatory activity
资金
- National Natural Science Foundation of China [41830535]
- Shandong Provincial Natural Science Foundation (Major Basic Research Projects) [ZR2019ZD18]
- Program of Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao, China)
- Taishan Scholars Program, China
- Natural Science Foundation of Hebei Province of China [H2021201059]
Three new polyketides were isolated from a marine-derived fungus, and their structures and configurations were determined. These compounds showed anti-inflammatory activities, with compounds 5 and 6 exhibiting the strongest effects.
Three new polyketides, eutyketides A and B (1 and 2) and cytosporin X (3), along with four known compounds (4-7), were obtained from the marine-derived fungus Eutypella scoparia. The planar structures of 1 and 2 were elucidated by extensive HRMS and 1D and 2D NMR analyses. Their relative configurations of C-13 and C-14 were determined with chemical conversions by introducing an acetonylidene group. The absolute configurations of 1-3 were determined by comparing their experimental electronic circular dichroism (ECD) data with their computed ECD results. All of the isolated compounds were tested for their anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages. Compounds 5 and 6 showed stronger anti-inflammatory activities than the other compounds, with the inhibition of 49.0% and 54.9% at a concentration of 50.0 mu g/mL, respectively.
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