Citri Reticulatae Semen Extract Promotes Healthy Aging and Neuroprotection via Autophagy Induction in Caenorhabditis elegans

Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in C. elegans and Cellular Models of Parkinson’s Disease

(2022) Tao Long et al.   Oxidative Medicine and Cellular Longevity

A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females

(2021) Brooke Zanco et al.   eLife

Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

(2021) Wu Zeng et al.   PHARMACOLOGICAL RESEARCH

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

(2020) Nicole L Jenkins et al.   eLife

Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans

(2020) Ai Ito et al.   BIOGERONTOLOGY

Age-dependent effects of floxuridine (FUdR) on senescent pathology and mortality in the nematode Caenorhabditis elegans

(2019) Hongyuan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy promotes visceral aging in wild-type C. elegans

(2019) Alexandre Benedetto et al.   Autophagy

Identification and determination of chemical constituents of Citrus reticulata semen through ultra high performance liquid chromatography combined with Q Exactive Orbitrap tandem mass spectrometry

(2019) GuoDong Zheng et al.   JOURNAL OF SEPARATION SCIENCE

Measuring biological aging in humans: A quest

(2019) Luigi Ferrucci et al.   AGING CELL

Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson’s disease

(2019) Nada Saewanee et al.   NEUROSCIENCE RESEARCH

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

(2018) Marina Ezcurra et al.   CURRENT BIOLOGY

Obacunone causes sustained expression of MKP-1 thus inactivating p38 MAPK to suppress pro-inflammatory mediators through intracellular MIF

(2017) Yuan Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth

(2017) Bin Qi et al.   eLife

Approaches for Studying Autophagy in Caenorhabditis elegans

(2017) Yanfang Chen et al.   Cells

Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery

(2016) Chun-Yan Shen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Obacunone activates the Nrf2-dependent antioxidant responses

(2016) Shengmei Xu et al.   Protein & Cell

Suppression of intestinal carcinogenesis in Apc-mutant mice by limonin

(2015) Satomi Shimizu et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

(2015) Jihoon Nah et al.   MOLECULES AND CELLS

Phenazine derivatives cause proteotoxicity and stress in C. elegans

(2015) Arpita Ray et al.   NEUROSCIENCE LETTERS

C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation

(2015) Jeong-Hoon Hahm et al.   Nature Communications

4-Hydroxybenzoic acid-mediated lifespan extension in Caenorhabditis elegans

(2014) Dae Keun Kim et al.   Journal of Functional Foods

Limonoids and their anti-proliferative and anti-aromatase properties in human breast cancer cells

(2012) Jinhee Kim et al.   Food & Function

Dietary Restriction and Aging: A Unifying Perspective

(2011) Matthew D.W. Piper et al.   Cell Metabolism

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE