Article
Plant Sciences
Ying-Ying Li, Zeng-Hui Tian, Shan-Shan Su, Jing-Jing Shi, Chao Zhou, Li-Hua Zhang, Fa-Rong Zhang, Yan-Ke Hao
Summary: This study showed that HDHW inhibits apoptosis of RTECs by modulating the PI3K/Akt/mTOR signaling pathway, providing experimental evidence for its anti-fibrotic effect on the kidneys and partially elucidating its pharmacological mechanism of action.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bihui Li, Xing Zhang, Qianyao Ren, Li Gao, Jing Tian
Summary: Despite promising results in vitro and preclinical studies, the dual PI3K/Akt/mTOR inhibitor NVP-BEZ235 and the ATP-competitive mTOR inhibitor PP242 failed to show inhibitory efficacy against renal cell carcinoma (RCC) in clinical settings. However, they both demonstrated marked effects by targeting TAK1-dependent pathways in RCC cells, especially NVP-BEZ235, suggesting potential application in combination therapy for RCC.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aarti Sharma, Sidharth Mehan
Summary: The PI3K-AKT/mTOR signaling pathway plays a crucial role in various biological processes and its dysregulation can lead to neurodevelopmental disorders like autism. Inhibiting this pathway may hold therapeutic value for autism treatment. The use of PI3K-AKT/mTOR signaling pathway inhibitors is currently being explored for the treatment of autism and other neurodegenerative disorders.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Veterinary Sciences
Jingsong Liu, Xueming Zhang, Shengnan Yue, Jingcheng Fu, Jin Chen, Ruochao Huang, Pengyuan Shang, Kai Zhong, Shuang Guo, Xianqin Jiao, Guangming Zha, Liqiang Han, Guoyu Yang, Heping Li, Yueying Wang
Summary: The study demonstrates that EPO promotes proliferation of MAC-T cells and has a better anti-inflammatory effect in cells treated with LPS, showing anti-apoptotic and anti-autophagic effects as well. These beneficial effects are dependent on the regulation of the PI3K/Akt/mTOR signaling pathway.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Qingsong Yang, Sizhen Li, Zixiu Zhou, Xiaodong Yang, Yating Liu, Kuanxiao Hao, Min Fu
Summary: The study found that Trimetazidine (TMZ) can inhibit excessive autophagy by activating the PI3K/Akt/mTOR pathway, thereby improving retinal endothelial dysfunction induced by high glucose.
Review
Biochemistry & Molecular Biology
Stefano Ratti, Raffaella Mauro, Cristina Rocchi, Sara Mongiorgi, Giulia Ramazzotti, Mauro Gargiulo, Lucia Manzoli, Lucio Cocco, Roberta Fiume
Summary: This review examines the importance of critical enzymes such as PI3K, AKT, and mTOR in the maturation and failure of arteriovenous fistula (AVF) for haemodialysis treatment. These enzymes play a role in various cellular activities and are associated with multiple diseases. They are also druggable targets, which can be targeted to control specific aspects of AVF and provide more personalized therapy.
Article
Cell Biology
I-Lun Hsin, Huang-Pin Shen, Hui-Yi Chang, Jiunn-Liang Ko, Po-Hui Wang
Summary: The study revealed a novel mechanism of the PI3K/mTOR dual inhibitor, PQR309, in lowering cell viability in endometrial cancer cells by disrupting the PI3K/Akt/mTOR/c-Myc/mtp53 positive feedback loop.
Article
Biochemistry & Molecular Biology
Belen Sanz-Castillo, Begona Hurtado, Diana Vara-Ciruelos, Aicha El Bakkali, Dario Hermida, Beatriz Salvador-Barbero, Diego Martinez-Alonso, Jose Gonzalez-Martinez, Clara Santiveri, Ramon Campos-Olivas, Pilar Ximenez-Embun, Javier Munoz, Monica Alvarez-Fernandez, Marcos Malumbres
Summary: This study reveals that the cell cycle kinase MASTL/Greatwall inhibits the activity of the PI3K-AKT signaling pathway by phosphorylating the PP2A/B55 inhibitor ENSA/ARPP19, thus limiting AKT activity. Furthermore, the study finds that MASTL is directly phosphorylated by mTORC1, which limits the dephosphorylation of IRS1 and GRB10 downstream of mTORC1, further restraining AKT activity. This research highlights the importance of the MASTL-PP2A/B55 kinase-phosphatase module in controlling AKT and maintaining metabolic homeostasis.
Review
Oncology
Wojciech Wiese, Julia Barczuk, Olga Racinska, Natalia Siwecka, Wioletta Rozpedek-Kaminska, Artur Slupianek, Radoslaw Sierpinski, Ireneusz Majsterek
Summary: The PI3K/Akt/mTOR pathway is crucial in cancer development and can be a potential therapeutic target for leukemia. Recent research indicates that inhibition of this pathway may lead to improved treatment outcomes for leukemia.
Review
Cell Biology
Jiawei Xu, Yu Li, Meili Kang, Cuicui Chang, Hong Wei, Chi Zhang, Yuhua Chen
Summary: Cell death is a natural biological process that is classified into different types. Investigating the details of cell death is crucial for finding effective targets for disease treatments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shike Yan, Bing Zhang, Jingwen Feng, Haigang Wu, Namin Duan, Yamin Zhu, Yueliang Zhao, Shuang Shen, Kai Zhang, Wenhui Wu, Ning Liu
Summary: FGFC1 selectively suppressed the growth of NSCLC cells with EGFR mutation, induced apoptosis of erlotinib-resistant NSCLC cells via mitochondrial dysfunction and ROS accumulation, and inhibited EGFR and its downstream PI3K/Akt/mTOR pathway by directly binding to EGFR. Additionally, FGFC1 inhibited the migration and invasion of NSCLC cells and effectively inhibited tumor growth in a xenograft model, indicating its potential as a candidate for erlotinib-resistant NSCLC therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Medicine, Research & Experimental
Nunghathai Sawasdee, Kanyaluck Jantakee, Methi Wathikthinnakon, Suthida Panwong, Jeeraporn Pekkoh, Kritsana Duangjan, Pa-thai Yenchitsomanus, Aussara Panya
Summary: The ethanolic extract from Chlorella sp. was found to inhibit the growth of five types of cancer cells and promote cancer cell death by inhibiting the AKT/mTOR pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yonghe Li, Yaolin Yin, Yi He, Kun He, Jingdong Li
Summary: This study investigated the influence of son of sevenless homolog 1 (SOS1) on invasion and metastasis of hepatocellular carcinoma (HCC) cells. High expression of SOS1 was observed in most human liver cancers, indicating a worse prognosis. Knockout of SOS1 significantly decreased cell invasion and migration, inhibited the epithelial-mesenchymal transition (EMT), and suppressed the PI3K/AKT/mTOR pathway. These findings suggest that SOS1 may play a role in promoting invasion, migration, and metastasis of HCC cells through the activation of the PI3K/AKT/mTOR pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)