标题
Rings in Clinical Trials and Drugs: Present and Future
作者
关键词
-
出版物
JOURNAL OF MEDICINAL CHEMISTRY
Volume 65, Issue 13, Pages 8699-8712
出版商
American Chemical Society (ACS)
发表日期
2022-06-22
DOI
10.1021/acs.jmedchem.2c00473
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Magic Rings: Navigation in the Ring Chemical Space Guided by the Bioactive Rings
- (2021) Peter Ertl Journal of Chemical Information and Modeling
- Structural Approach to Assessing the Innovativeness of New Drugs Finds Accelerating Rate of Innovation
- (2020) Todd J. Wills et al. ACS Medicinal Chemistry Letters
- Ultra-large library docking for discovering new chemotypes
- (2019) Jiankun Lyu et al. NATURE
- Estimation of clinical trial success rates and related parameters
- (2018) Chi Heem Wong et al. BIOSTATISTICS
- Virtual Exploration of the Ring Systems Chemical Universe
- (2017) Ricardo Visini et al. Journal of Chemical Information and Modeling
- Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery
- (2016) Richard D. Taylor et al. JOURNAL OF MEDICINAL CHEMISTRY
- Current kinase inhibitors cover a tiny fraction of fragment space
- (2015) Hongtao Zhao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Mappability of drug-like space: towards a polypharmacologically competent map of drug-relevant compounds
- (2015) Pavel Sidorov et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- SureChEMBL: a large-scale, chemically annotated patent document database
- (2015) George Papadatos et al. NUCLEIC ACIDS RESEARCH
- PubChem Substance and Compound databases
- (2015) Sunghwan Kim et al. NUCLEIC ACIDS RESEARCH
- Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
- (2014) Bradley Croy Doak et al. CHEMISTRY & BIOLOGY
- Intuitive Ordering of Scaffolds and Scaffold Similarity Searching Using Scaffold Keys
- (2014) Peter Ertl Journal of Chemical Information and Modeling
- Rings in Drugs
- (2014) Richard D. Taylor et al. JOURNAL OF MEDICINAL CHEMISTRY
- Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces
- (2014) Jonghoon Kim et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The 'rule of three' for fragment-based drug discovery: where are we now?
- (2013) Harren Jhoti et al. NATURE REVIEWS DRUG DISCOVERY
- Database of bioactive ring systems with calculated properties and its use in bioisosteric design and scaffold hopping
- (2012) Peter Ertl BIOORGANIC & MEDICINAL CHEMISTRY
- Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17
- (2012) Lars Ruddigkeit et al. Journal of Chemical Information and Modeling
- ZINC: A Free Tool to Discover Chemistry for Biology
- (2012) John J. Irwin et al. Journal of Chemical Information and Modeling
- Quantifying the chemical beauty of drugs
- (2012) G. Richard Bickerton et al. Nature Chemistry
- Drug discovery in the next decade: innovation needed ASAP
- (2011) Youssef L. Bennani DRUG DISCOVERY TODAY
- Matched Molecular Pairs as a Medicinal Chemistry Tool
- (2011) Ed Griffen et al. JOURNAL OF MEDICINAL CHEMISTRY
- ChEMBL: a large-scale bioactivity database for drug discovery
- (2011) A. Gaulton et al. NUCLEIC ACIDS RESEARCH
- Privileged scaffolds for library design and drug discovery
- (2010) Matthew E Welsch et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Best Practices for QSAR Model Development, Validation, and Exploitation
- (2010) Alexander Tropsha Molecular Informatics
- Heteroaromatic Rings of the Future
- (2009) William R. Pitt et al. JOURNAL OF MEDICINAL CHEMISTRY
- 970 Million Druglike Small Molecules for Virtual Screening in the Chemical Universe Database GDB-13
- (2009) Lorenz C. Blum et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery
- (2009) Roman Kombarov et al. MOLECULAR DIVERSITY
- Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
- (2008) M. Paul Gleeson JOURNAL OF MEDICINAL CHEMISTRY
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