Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This analysis reviewed the literature related to the management of AK to provide evidence-based recommendations for treatment. Strong recommendations were made for using ultraviolet protection, topical medications, and cryosurgery to treat AK. Conditional recommendations were made for photodynamic therapy and diclofenac for the treatment of AK.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This study provides a summary of 18 evidence-based recommendations for the treatment of actinic keratoses, highlighting the effectiveness of treatments such as ultraviolet protection, topical medications, and cryosurgery. The recommendations are subject to limitations, and future research may alter current treatment guidelines.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elena Campione, Monia Di Prete, Cosimo Di Raimondo, Gaetana Costanza, Vincenzo Palumbo, Virginia Garofalo, Sara Mazzilli, Chiara Franceschini, Emi Dika, Luca Bianchi, Augusto Orlandi
Summary: This study evaluated the clinical efficacy of three different therapeutic modalities for actinic keratosis and assessed the expression of matrix metalloproteinases through histopathological examination and immunohistochemistry. The results showed a gradual decrease in actinic keratosis assessment scores at the end of treatments and a reduction in matrix metalloproteinase expression in treated skin lesions compared to baseline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Miguel Fernando Garcia-Gil, Tamara Gracia-Cazana, Paulina Cerro-Munoz, Laura Bernal-Masferrer, Alba Navarro-Bielsa, Yolanda Gilaberte
Summary: This study evaluates the effectiveness and safety of methyl aminolevulinate daylight photodynamic therapy (MAL DL-PDT) performed at home. The results show that MAL DL-PDT is highly effective for the long-term treatment of nonhyperkeratotic actinic keratosis (AK), with a high level of patient satisfaction.
DERMATOLOGIC THERAPY
(2022)
Article
Pharmacology & Pharmacy
Joanna Bartosinska, Paulina Szczepanik-Kulak, Dorota Raczkiewicz, Marta Niewiedziol, Agnieszka Gerkowicz, Dorota Kowalczuk, Miroslaw Kwasny, Dorota Krasowska
Summary: The study evaluated the efficacy and cosmetic outcome of different photosensitizers in AK patients, indicating that ALA-P may have better effects and lower pain intensity compared to ALA-HCl and MAL-HCl.
Article
Oncology
Qin Yi, Jiayan Liu
Summary: It has been found that photodynamic therapy combined with surgical excision has a good therapeutic efficacy in patients with actinic keratosis (AK), and the risk factors for secondary cutaneous squamous cell carcinoma (cSCC) have been analyzed.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yeakuty Jhanker, Melinda N. Mbano, Thellie Ponto, Lore Jane L. Espartero, Miko Yamada, Tarl Prow, Heather A. E. Benson
Summary: Physical drug delivery enhancement technologies, including microneedles, dermarollers, and elongated microparticles, have been shown to significantly improve the penetration and retention of mALA in pig skin. Different technologies demonstrate varying levels of efficacy in enhancing drug permeation and deposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Oncology
Isabella J. Tan, Gaurav N. Pathak, Frederick H. Silver
Summary: Basal cell carcinoma (BCC) and actinic keratosis (AK) are common skin lesions in dermatology clinics. Topical treatments have been proven to effectively treat early forms of superficial BCC, reducing the need for unnecessary biopsies and lowering the economic burden of healthcare. With the increasing prevalence of BCC and AK, topical therapies offer cost-effective treatment options that minimize invasive procedures and associated risks.
Article
Dermatology
Soo Ick Cho, Hanjae Lee, Soyun Cho
Summary: According to this study, patients with rosacea have an increased risk of developing actinic keratosis and keratinocyte carcinoma, while the risk of cutaneous melanoma and gastric, colorectal, and liver cancer is not increased.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Dermatology
Taylor A. Bullock, Jeffrey Negrey, Bo Hu, Christine B. Warren, Tayyaba Hasan, Edward Maytin
Summary: The study found that oral VD3 pretreatment significantly improves the clinical response of AK patients to PDT, and this treatment shows good tolerance.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Jason Thomson, Findlay Bewicke-Copley, Chinedu Anthony Anene, Abha Gulati, Ai Nagano, Karin Purdie, Gareth J. Inman, Charlotte M. Proby, Irene M. Leigh, Catherine A. Harwood, Jun Wang
Summary: This study conducted the largest AK whole exome sequencing study to date and found significant similarities between AK and cSCC in terms of genetic mutations, copy number alterations, driver gene mutations, and mutational signatures. The research identified 44 significantly mutated AK driver genes and suggested that dysregulated TGFf3 signaling may play an important role in AK-cSCC progression.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Dermatology
Aaron S. Farberg, Justin W. Marson, Teo Soleymani
Summary: Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) as a photosensitization agent is approved for the treatment of actinic keratoses (AKs) in the USA. PDT has also been used off-label for nonmelanoma skin cancers. Advantages of PDT include improved cosmesis, while disadvantages include pain. The objective of this review is to discuss current research on topical photosensitizers and modified light delivery regimens to achieve better treatment outcomes with less toxicity in patients with AK, cSCC, BCC, and field cancerization.
DERMATOLOGY AND THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Ewelina Mazur, Dominika Kwiatkowska, Adam Reich
Summary: This review summarizes the effectiveness of photodynamic therapy (PDT) in treating pigmented basal cell carcinoma (BCC) based on current literature. PDT is a light-activated treatment that selectively destroys tumor cells and tissues. However, factors like melanin in the skin can decrease the success of PDT. Various factors, including tumor depth, the degree of pigmentation, and skin phototype, can impact the outcome of this treatment. While PDT is considered to have limited efficacy in treating pigmented lesions, new combination techniques show promising results.
Article
Oncology
Lauren E. Heusinkveld, Taylor A. Bullock, Jeffrey Negrey, Christine B. Warren, Edward V. Maytin
Summary: This study aimed to compare the efficacy of photodynamic therapy (PDT) with or without sandpaper curettage for the treatment of actinic keratosis (AK). The results showed that patients who received sandpaper curettage before PDT treatment had a significantly higher scalp AK clearance rate compared to those who did not receive curettage, after controlling for sex, age, time to follow-up, and baseline AK count.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Clara Curiel-Lewandrowski, Caitlyn N. Myrdal, Kathylynn Saboda, Chengcheng Hu, Edith Arzberger, Giovanni Pellacani, Franz Josef Legat, Martina Ulrich, Petra Hochfellner, Margaret C. Oliviero, Paola Pasquali, Melissa Gill, Rainer Hofmann-Wellenhof
Summary: Non-invasive imaging technology, such as reflectance confocal microscopy, has the potential to enhance the evaluation of actinic keratoses (AKs) and monitor treatment responses over time. Standardized RCM protocols may enable better comparison across clinical trials and early detection of relapses.
Article
Dermatology
Anna Szymanska, Elzbieta Budzisz, Anna Erkiert-Polguj
Summary: The 30% azelaic acid peel was found to significantly reduce sebum secretion and acne lesions, with good tolerance among participants.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Dermatology
Anna Erkiert-Polguj, Barbara Algiert-Zielinska, Janusz Skubalski, Helena Rotsztejn
Summary: The study indicated that using the IPL system alone and combining it with RF yielded similar results in hair reduction, but the combined treatment was more effective in long-term observations. These therapies were found to be safe, effective, and comfortable for patients with skin phototypes II or III.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Dermatology
Sylwia Jarzabek, Helena Rotsztejn
Summary: The study involved 27 female subjects who received five oxygen microdermabrasion treatments every 2 weeks. Measurements of skin parameters were taken before and 2 weeks after the last treatment, with measurement points on the forehead, cheek, and nose petal. Results showed that oxybrasion treatments increase skin hydration and have a significant influence on the decrease of the skin hydrolipid coat and pH.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Review
Dermatology
Anna Kolodziejczak, Helena Rotsztejn
Summary: The eye area is of great importance in esthetic dermatology and difficult to treat. Skillful treatment can greatly improve the quality of life for patients. This study aims to present different changes in the eye area and factors that affect their appearance and intensity. Treatment methods for various eye area problems are also discussed. Proper diagnosis requires understanding the skin structure and its disorders. Many people simplify eye area problems to shadows, swelling, and wrinkles, and only focus on one form of therapy. However, as shown in this review, there are a variety of defects. Treating eye area problems requires a systematic and multi-specialist approach.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Emilia Scieszko, Emilian Budny, Helena Rotsztejn, Anna Erkiert-Polguj
Summary: The study found that during the pandemic, women paid more attention to facial care, engaged in more comprehensive home skincare routine, which had a positive impact on their skin. Additionally, the importance of the Internet significantly increased as a source of knowledge in cosmetology and a thriving market for cosmetic products.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Engineering, Biomedical
Anna Kolodziejczak, Helena Rotsztejn
Summary: This study evaluated the effects of non-ablative fractional laser, bipolar radiofrequency, and intense pulsed light on skin elasticity and wrinkles, all of which showed improvements in these aspects. However, participants did not observe significant impacts of these methods on other signs of skin aging.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Dermatology
Sylwia Jarzabek-Perz, Paulina Mucha, Helena Rotsztejn
Summary: The study found that there was a significant increase in facial skin hydration after the application of gluconolactone solution, with no significant differences between the 10% and 30% solutions. It concludes that gluconolactone is an effective moisturizing substance for dry skin care.
SKIN RESEARCH AND TECHNOLOGY
(2021)
Review
Dermatology
Mirella Batory, Helena Rotsztejn
Summary: Shikimic acid is a multifunctional cosmetic ingredient with antiviral, exfoliating, deodorizing, anti-acne, anti-dandruff, whitening and moisturizing properties. It also regulates sebum production, has antibacterial, anti-inflammatory, hair growth stimulating, anti-aging effects, and antifungal properties.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Anna Szymanska, Elzbieta Budzisz, Anna Erkiert-Polguj
Summary: A series of six treatments using near-infrared low-level laser therapy resulted in significant improvements in acne lesions and a notable decrease in skin sebum excretion. The study concludes that this treatment option is safe and effective for acne vulgaris.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Dermatology
Anna Szymanska, Elzbieta Budzisz, Anna Erkiert-Polguj
Summary: The study assessed the effectiveness of a 20% azelaic acid solution on seborrhea in acne patients, showing a decrease in sebum levels post-treatment. The total number of acne lesions and disease severity also significantly improved, indicating the long-term sebostatic action of the chemical peel with 20% azelaic acid.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Kamila Zdunska-Peciak, Anna Kolodziejczak, Helena Rotsztejn
Summary: The study on the effects of ascorbic acid and ferulic acid treatment on the signs of photoaging showed significant improvements in skin hydration, melanin level, elasticity, and erythema intensity. Both acids demonstrated statistically significant impact on these skin parameters.
DERMATOLOGIC THERAPY
(2022)
Article
Medicine, General & Internal
Agata Markiewicz-Tomczyk, Elzbieta Budzisz, Anna Erkiert-Polguj
Summary: Combined methods of applying chemical peels and antioxidants with microneedle mesotherapy showed promising results for skin rejuvenation in a study involving 20 female volunteers. The use of a 40% vitamin C solution with microneedling and a 10% vitamin C solution without microneedling, in addition to azelaic acid, significantly improved hydration, skin elasticity, and reduced melanin and erythema index. The combination of active ingredients and delivery techniques has great potential to enhance cosmetic preparations' effectiveness in multiple ways.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
M. Zasada, A. Erkiert-Polguj, M. Markowicz-Piasecka, A. Bakiewicz, E. Budzisz
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2020)
