Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne M. Wong, Phoebe Luo, Benjamin Keunen, Samuel Pichardo, James M. Drake, Adam C. Waspe
Summary: An adaptive targeting algorithm was developed for real-time correction of misplanned hyperthermia treatments, improving the accuracy and precision of MRgHIFU therapy.
Article
Chemistry, Multidisciplinary
Xiaojing Wang, Gun Kim, James L. Chu, Tingjie Song, Zhenglin Yang, Weijie Guo, Xiangli Shao, Michael L. Oelze, King C. Li, Yi Lu
Summary: In this study, high-intensity focused ultrasound (HIFU) was successfully used to remotely activate DNAzyme sensors for high spatiotemporal resolution detection of metal ions in both in vitro and in vivo settings. The effectiveness of this approach was demonstrated by Zn2+-specific fluorescent resonance energy transfer (FRET) imaging in HeLa cells and mice. These findings offer new possibilities for in vivo imaging and medical diagnosis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Marta Ribeiro, Meriem Boudoukhani, Efres Belmonte-Reche, Nuria Genicio, Sanna Sillankorva, Juan Gallo, Carlos Rodriguez-Abreu, Nadji Moulai-Mostefa, Manuel Banobre-Lopez
Summary: This study introduces a biocompatible hydrogel with magnetic nanoparticles, allowing controlled drug release and non-invasive monitoring, which is crucial for precise treatment of internal diseases.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xiaojing Wang, Gun Kim, James L. Chu, Tingjie Song, Zhenglin Yang, Weijie Guo, Xiangli Shao, Michael L. Oelze, King C. Li, Yi Lu
Summary: This study presents a novel method for detecting metal ions in vivo by combining high-intensity focused ultrasound with DNAzyme sensors. The thermal energy delivered by HIFU can activate the DNAzyme sensors, enabling the recognition of metal ions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Shan Gao, Yutaka Miura, Akira Sumiyoshi, Satoshi Ohno, Keisuke Ogata, Takahiro Nomoto, Makoto Matsui, Yuto Honda, Minoru Suzuki, Megumi Iiyama, Kensuke Osada, Ichio Aoki, Nobuhiro Nishiyama
Summary: Nano-sized contrast agents (NCAs) have the potential to enhance tumor contrast during magnetic resonance imaging. This study introduces a novel molecular mechanism to enhance the relaxation of NCAs, resulting in sharp tumor imaging. The self-folding molecular design allows for minimal loading of gadolinium complexes and selective accumulation in tumor tissues, providing effective anti-tumor results through gadolinium neutron capture therapy.
Review
Pharmacology & Pharmacy
Harshini Ashar, Ashish Ranjan
Summary: High intensity focused ultrasound (HIFU) is a non-invasive therapeutic technology that uses sonic energy to induce thermal and non-thermal effects in tissues. It can ablate tissues, improve drug delivery, and mechanically fragment cells. HIFU has potential applications in treating cancers, infectious diseases, and neuromodulation. This review discusses the role of HIFU in enhancing drug delivery and immunomodulation in soft and calcified tissues.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Engineering, Environmental
Tianzhi Liu, Qian Wan, Chao Zou, Mengjie Chen, Gang Wan, Xin Liu, Hangrong Chen
Summary: This study demonstrates the sophisticated combination of smart mesoporous nanocarriers and the MR-FUS technique for precise regulation of drug release kinetics. Utilizing temperature control and phase transition mechanisms, the efficiency of multi-modal drug release is enhanced, showing significant tumor growth inhibition in in vivo experiments.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Engineering, Biomedical
Vismaya S. Bachu, Jayanidhi Kedda, Ian Suk, Jordan J. Green, Betty Tyler
Summary: HIFU is an emerging and increasingly useful modality in the treatment of cancer and other diseases, using high-energy ultrasound pulses to target specific areas while minimizing damage to surrounding tissues. Its wide applications across various tumor types and organ systems, along with its potential future pathways, highlight the growing importance of this technology in biomedical fields.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Lorena Garcia-Hevia, Inigo Casafont, Jessica Oliveira, Nuria Teran, Monica L. Fanarraga, Juan Gallo, Manuel Banobre-Lopez
Summary: Currently, there are various promising strategies being developed to combine diagnostic and therapeutic capabilities in clinically effective formulations. In this study, a biocompatible magnetic lipid nanocomposite vehicle was created using an efficient and environmentally-friendly method to incorporate magnetic nanoparticles and an anticancer drug. The magnetic formulation showed excellent theranostic performance in vitro and in vivo, enhancing the anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Pengchao Zhao, Jiaxin Guo, Tianshen Jiang, Xiayi Xu, Sirong Chen, Zhuo Li, Jiankun Xu, Gang Li, Liming Bian
Summary: Developing a generalizable delivery system that can control the release of diverse macromolecular drugs is crucial for the treatment of various diseases. In this study, we utilized a vacuolated coacervate, which acts as a barrier to regulate the release rate of macromolecules. By applying ultrasound, the coacervate matrix can be temporarily disrupted, leading to burst release of the macromolecules. The liquidity of the nanoparticle-assembled coacervate allows for rapid recovery of the coacervate matrix, enabling long-term linear release of the macromolecules. This concept of using a vacuolated coacervate-based macromolecular reservoir has great potential in the treatment of different diseases.
Review
Oncology
Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Summary: Magnetic Particle Imaging (MPI) is an emerging imaging technique that provides direct imaging of superparamagnetic iron oxide nanoparticles, showing great potential in cancer diagnosis and therapy monitoring. Different from MRI, MPI offers ideal image contrast with zero background tissue signal, enabling clear visualization of cancer. MPI enhances therapeutic precision and accuracy through magnetic means, contributing to the advancement of cancer imaging and guided therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinrui Zhang, Lisa Landgraf, Nikolaos Bailis, Michael Unger, Thies H. Jochimsen, Andreas Melzer
Summary: Image-guided high-intensity focused ultrasound (HIFU) has gained increasing popularity in medicine for tumor ablation, neurological disease treatment, and bone metastases management. The mechanical and thermal effects of focused ultrasound enable tissue histotripsy, supportive radiation therapy, and targeted drug delivery. Integration of imaging modalities into HIFU systems enhances treatment precision and safety, showing potential to reduce adverse effects and improve postoperative quality of life.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Evgenii Kim, Jared Van Reet, Hyun-Chul Kim, Kavin Kowsari, Seung-Schik Yoo
Summary: Low-intensity transcranial focused ultrasound (FUS) is a non-/minimally-invasive therapy that facilitates drug delivery to the brain and modulates brain tissue excitability. However, research has shown that FUS may exacerbate local cerebrovascular injury and result in intracerebral hemorrhaging. Therefore, caution should be taken when using FUS in individuals with weakened vascular integrity.
Review
Oncology
Rajneesh Mungur, Jiesheng Zheng, Ben Wang, Xinhua Chen, Renya Zhan, Ying Tong
Summary: The use of LIFU+MBs in drug delivery for glioblastoma has shown to be a safe and effective method, with improved drug uptake and tumor control without causing harm to brain structures.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Sitong Liu, Xiuqi Hou, Wenjian Zhu, Fang Zhang, Weiling Chen, Binjian Yang, Xin Luo, Dalin Wu, Zhong Cao
Summary: Magnetic resonance imaging-guided high-intensity focused ultrasound (MRI-guided HIFU) is a non-invasive strategy for tumor diagnosis and treatment. Researchers prepared a multifunctional nanotheranostic agent (SSPN) by loading perfluorohexane (PFH) and superparamagnetic iron oxides (SPIOs) in silica lipid, aiming for MRI-guided HIFU ablation of tumors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Henrik Odeen, Nick Todd, Christopher Dillon, Allison Payne, Dennis L. Parker
MAGNETIC RESONANCE IN MEDICINE
(2016)
Article
Biophysics
Christopher Dillon, Robert Roemer, Allison Payne
NMR IN BIOMEDICINE
(2015)
Article
Oncology
Sara L. Johnson, Christopher Dillon, Henrik Odeen, Dennis Parker, Douglas Christensen, Allison Payne
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexis I. Farrer, Scott Almquist, Christopher R. Dillon, Leigh A. Neumayer, Dennis L. Parker, Douglas A. Christensen, Allison Payne
Article
Engineering, Biomedical
C. R. Dillon, G. Borasi, A. Payne
PHYSICS IN MEDICINE AND BIOLOGY
(2016)
Article
Engineering, Biomedical
Y. C. Shi, D. L. Parker, C. R. Dillon
PHYSICS IN MEDICINE AND BIOLOGY
(2016)
Article
Oncology
Christopher R. Dillon, Viola Rieke, Pejman Ghanouni, Allison Payne
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2018)
Article
Nanoscience & Nanotechnology
Nick Frazier, Allison Payne, Christopher Dillon, Nithya Subrahmanyam, Hamidreza Ghandehari
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2017)
Article
Oncology
Christopher R. Dillon, Alexis Farrer, Hailey McLean, Scott Almquist, Douglas Christensen, Allison Payne
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2018)
Article
Oncology
Christopher R. Dillon, Allison Payne, Douglas A. Christensen, Robert B. Roemer
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2014)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bryant T. Svedin, Christopher R. Dillon, Dennis L. Parker
MAGNETIC RESONANCE IN MEDICINE
(2019)
Article
Oncology
Sara L. Johnson, Douglas A. Christensen, Christopher R. Dillon, Allison Payne
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher Dillon, Maryam Rezvani, Hailey McLean, Marisa Adelman, Mark Dassel, Elke Jarboe, Margit Janat-Amsbury, Allison Payne
Article
Oncology
Robb Merrill, Henrik Odeen, Christopher Dillon, Rachelle Bitton, Pejman Ghanouni, Allison Payne
Summary: The study introduces an open-source MRgFUS active skin cooling system to reduce skin burns during treatment of superficial tissues. By using a conformable skin-cooling pad assembly with feedback control, the system maintains continuous flow and pressure during the procedure, showing promising results in reducing skin burns.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
