Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Review
Pharmacology & Pharmacy
Maria P. Nikolova, Enamala Manoj Kumar, Murthy S. Chavali
Summary: Liposomes are nanoparticles capable of incorporating both hydrophilic and hydrophobic drugs simultaneously. They offer numerous advantages over conventional drug delivery systems, particularly in targeted delivery.
Review
Pharmacology & Pharmacy
Antonia Antoniou, Sabrina Giofre, Pierfausto Seneci, Daniele Passarella, Sara Pellegrino
Summary: Liposomes are lipidic supramolecular aggregates with the ability to encapsulate and carry molecules of various natures, making them ideal for drug delivery systems. Recent advancements in chemical modifications have led to the development of smart liposome-based drug delivery systems with tunable features and disease-directed capabilities.
DRUG DISCOVERY TODAY
(2021)
Article
Chemistry, Applied
Eunhye Yang, Ho-Sup Jung, Pahn-Shick Chang
Summary: In this study, a stimulus-responsive polymer complex called capsosomes containing trilaurin-based solid lipid nanoparticles (SLNs) known as CSLNs was prepared for the oral delivery of hydrophilic molecules. The capsosomes showed improved stability and prolonged retention time under small intestinal conditions and bypassed the gastrointestinal tract. These findings demonstrate the potential application of pH-sensitive capsosomes for the oral delivery of food nutraceuticals.
FOOD HYDROCOLLOIDS
(2022)
Article
Nanoscience & Nanotechnology
Luoping Zhai, Chuangwei Luo, Hannan Gao, Shuaifan Du, Jiyun Shi, Fan Wang
Summary: The study designed a dual pH-responsive DOX-encapsulated liposome targeting the acidic tumor microenvironment, utilizing acid-sensitive peptide (DVar7) and acid-sensitive phospholipid (DOPE) responses to increase uptake and controlled release of DOX. Results showed that DVar7 enhanced liposome uptake in tumors and prolonged retention time, with further enhancement in therapeutic efficacy by regulating tumor acidity with glucose injection. This strategy has the potential to improve drug resistance in clinical practice and enhance the therapeutic effect of chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nikolaos Naziris, Natassa Pippa, Evangelia Sereti, Varvara Chrysostomou, Marta Kedzierska, Jakub Kajdanek, Maksim Ionov, Katarzyna Milowska, Lucja Balcerzak, Stefano Garofalo, Cristina Limatola, Stergios Pispas, Konstantinos Dimas, Maria Bryszewska, Costas Demetzos
Summary: This study developed functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer for the delivery of the antiglioma agent TRAM-34 inside glioblastoma cells. The nanosystems exhibited functional properties under pH conditions, as well as biocompatibility and cellular internalization. These chimeric nanoplatforms show promise for biomedical applications and should be further studied for delivering therapeutic molecules to glioblastoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Milad Ashrafizadeh, Masoud Delfi, Ali Zarrabi, Ashkan Bigham, Esmaeel Sharifi, Navid Rabiee, Ana Claudia Paiva-Santos, Alan Prem Kumar, Shing Cheng Tan, Kiavash Hushmandi, Jun Ren, Ehsan Nazarzadeh Zare, Pooyan Makvandi
Summary: This review discusses the use of stimuli-responsive liposomes for targeted drug delivery in cancer therapy. These liposomes can be triggered by various stimuli such as pH, redox, enzymes, light, heat, and magnetic field to release drugs at tumor sites. The stimuli-responsive liposomes have shown great potential in improving the efficacy of anticancer drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Environmental
Biao Liu, Jinrong Wang, Yongbo Peng, Hongliang Zeng, Qun Zhang, Minhua Deng, Wei Xiang, Jiahao Liu, Xing Hu, Xuewen Liu, Jianfei Xie, Weibin Hou, Jin Tang, Zhi Long, Long Wang, Jianye Liu
Summary: Conventional chemotherapy cannot specifically target cancer cells, leading to damage to normal tissues and organs. In addition, cancer stem cells (CSCs)-induced tumor regrowth and drug resistance limit the effectiveness of certain chemotherapy drugs. This study developed a CD71/CD44 dual-aptamer-gemcitabine (CD71-CD44-GEMs) conjugate for treating bladder cancer by targeting bladder cancer cells and bladder CSCs. The results showed that CD71-CD44-GEMs had selective binding and high inhibitory effects on bladder cancer both in vitro and in vivo. It also exhibited stronger binding affinity and inhibitory efficacy compared to CD71-GEMs or CD44-GEMs in bladder cancer. Therefore, CD71-CD44-GEMs represents a promising approach for bladder cancer treatment as it can effectively target both bladder cancer cells and CSCs and deliver drugs efficiently.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Jana K. Alwattar, Amina T. Mneimneh, Kawthar K. Abla, Mohammed M. Mehanna, Ahmed N. Allam
Summary: The era of nanotechnology has brought about novel research strategies in drug delivery, with liposomes and metal nanocarriers showing distinctive advantages but also limitations. By combining the criteria of both liposomes and metallic moieties, nanohybrid systems offer a promising approach for successful theranostic delivery, particularly in combating diseases like cancer.
Article
Pharmacology & Pharmacy
Federica Rinaldi, Jacopo Forte, Giada Pontecorvi, Patrizia Nadia Hanieh, Alessandra Care, Maria Bellenghi, Valentina Tirelli, Maria Grazia Ammendolia, Gianfranco Mattia, Carlotta Marianecci, Rossella Puglisi, Maria Carafa
Summary: This study focused on the development of nanoemulsions and niosomes containing oleic acid for the treatment of melanoma, aiming to improve drug delivery efficiency and reduce toxicity. Results showed that these new nanostructures exhibited stability, pH-sensitivity, efficient cellular uptake, and no cell toxicity, indicating their potential as a powerful strategy for metastatic melanoma therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
S. Umesh, S. Sarkar, S. Bera, P. Moitra, S. Bhattacharya
Summary: A new hydrogel was developed by mixing 5'-guanosine monophosphate disodium salt and 1,4,5,8-naphthalene tetracarboxylic acid tetra potassium salt. The hydrogel showed excellent stability and pH-responsive properties. It was used for the encapsulation and delivery of an anticancer drug, and demonstrated high drug loading capacity and controlled release capabilities. In vivo studies showed significant regression of tumor volume after administration of the drug-loaded hydrogel.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Bidyut Kumar Pragti, Bidyut Kumar Kundu, Satyam Singh, Wilson Alphonse Carlton Ranjith, Sayantan Sarkar, Avinash Sonawane, Suman Mukhopadhyay
Summary: This study demonstrates the potential of pH-responsive nanogels to improve chemotherapy outcomes for human cancer cells. The nanogels exhibited high efficacy and selectivity towards cancer cells, and the synthesized compounds also showed the ability to generate radical oxygen species within cells.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Fan Li, Yan Liang, Miaochen Wang, Xing Xu, Fen Zhao, Xu Wang, Yong Sun, Wantao Chen
Summary: The pH cascade-responsive micellar nanoplatform with nucleus-targeted ability effectively combines synergistic chemo-photodynamic therapy for cancer treatment. The novel multifunctional nanoplatform demonstrates high anticancer efficacy both in vitro and in vivo, making it a promising candidate for synergistic anticancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Yongjia Huang, Tingting Wang, Qunyou Tan, Dan He, Mingjun Wu, Jingchuan Fan, Jie Yang, Cailing Zhong, Kailing Li, Jingqing Zhang
Summary: The article discusses the challenges of delivering therapeutic agents specifically to dysfunctional mitochondria in tumor progression and presents a variety of pathways to achieve smart stimuli-responsive and mitochondria-targeted drug delivery systems. These systems not only target the mitochondria with precision but also respond to internal and external stimuli to increase efficacy and reduce side effects, showing promise as a potential precision medicine for cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Eirik A. L. Rustad, Susannah von Hofsten, Robin Kumar, Eirik A. Laensman, Gerd Berge, Natasa Skalko-Basnet
Summary: Nanomedicine has been successful in developing superior anticancer therapies, but there are still challenges in treating certain tumors, such as glioblastoma. In this study, pH-responsive liposomes were used to deliver drugs to glioblastoma cells, taking advantage of the acidic extracellular environment. The results showed improved intracellular uptake of drugs in glioblastoma cells compared to non-pH-responsive liposomes, regardless of the length of PEG.
Article
Oncology
Maria Vittoria Dieci, Luisa Carbognin, Federica Miglietta, Fabio Canino, Carlo Alberto Giorgi, Enrico Cumerlato, Ottavia Amato, Davide Massa, Gaia Griguolo, Elisa Genovesi, Giovanna Garufi, Diana Giannarelli, Antonio Tornincasa, Lucia Trudu, Silvia Michieletto, Tania Saibene, Marcello Lo Mele, Matteo Fassan, Giovanni Zarrilli, Federico Piacentini, Emilio Bria, Valentina Guarneri
Summary: This study demonstrates that incorporating carboplatin into neoadjuvant chemotherapy significantly improves pathological complete response (pCR) in triple-negative breast cancer (TNBC) patients. Additionally, the combination of anthracycline-taxane chemotherapy with carboplatin enhances immune infiltration. Finally, the increase in tumor-infiltrating lymphocytes (TILs) after neoadjuvant chemotherapy exposure is independently associated with distant disease-free survival.
BRITISH JOURNAL OF CANCER
(2023)
Correction
Multidisciplinary Sciences
Yilong Li, Nicola D. Roberts, Jeremiah A. Wala, Ofer Shapira, Steven E. Schumacher, Kiran Kumar, Ekta Khurana, Sebastian Waszak, Jan O. Korbel, James E. Haber, Marcin Imielinski, Joachim Weischenfeldt, Rameen Beroukhim, Peter J. Campbell
Correction
Multidisciplinary Sciences
Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C. Dentro, Santiago Gonzalez, Daniel Rosebrock, Thomas J. Mitchell, Yulia Rubanova, Pavana Anur, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vazquez-Garcia, Kerstin Haase, Lara Jerman, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, Nilgun Donmez, Dimitri G. Livitz, Marek Cmero, Jonas Demeulemeester, Steven Schumacher, Yu Fan, Xiaotong Yao, Juhee Lee, Matthias Schlesner, Paul C. Boutros, David D. Bowtell, Hongtu Zhu, Gad Getz, Marcin Imielinski, Rameen Beroukhim, S. Cenk Sahinalp, Yuan Ji, Martin Peifer, Florian Markowetz, Ville Mustonen, Ke Yuan, Wenyi Wang, Quaid D. Morris, Paul T. Spellman, David C. Wedge, Peter Van Loo
Correction
Multidisciplinary Sciences
Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Jeremiah A. Wala, Ofer Shapira, Grace Tiao, Henrik Hornshoj, Julian M. Hess, Randi Istrup Juul, Ziao Lin, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andres Lanzos, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Pratiti Bandopadhayay, Johanna Bertl, Keith A. Boroevich, John Busanovich, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, David Craft, Priyanka Dhingra, Klev Diamanti, Nuno A. Fonseca, Abel Gonzalez-Perez, Qianyun Guo, Mark P. Hamilton, Nicholas J. Haradhvala, Chen Hong, Keren Isaev, Todd A. Johnson, Malene Juul, Andre Kahles, Abdullah Kahraman, Youngwook Kim, Jan Komorowski, Kiran Kumar, Sushant Kumar, Donghoon Lee, Kjong-Van Lehmann, Yilong Li, Eric Minwei Liu, Lucas Lochovsky, Keunchil Park, Oriol Pich, Nicola D. Roberts, Gordon Saksena, Steven E. Schumacher, Nikos Sidiropoulos, Lina Sieverling, Nasa Sinnott-Armstrong, Chip Stewart, David Tamborero, Jose M. C. Tubio, Husen M. Umer, Liis Uuskuela-Reimand, Claes Wadelius, Lina Wadi, Xiaotong Yao, Cheng-Zhong Zhang, Jing Zhang, James E. Haber, Asger Hobolth, Marcin Imielinski, Manolis Kellis, Michael S. Lawrence, Christian von Mering, Hidewaki Nakagawa, Benjamin J. Raphael, Mark A. Rubin, Chris Sander, Lincoln D. Stein, Joshua M. Stuart, Tatsuhiko Tsunoda, David A. Wheeler, Rory Johnson, Jueri Reimand, Mark Gerstein, Ekta Khurana, Peter J. Campbell, Nuria Lopez-Bigas, Joachim Weischenfeldt, Rameen Beroukhim, Inigo Martincorena, Jakob Skou Pedersen, Gad Getz
Letter
Cell Biology
Andrea Remo, Federica Grillo, Alessandro Vanoli, Paola Parente, Luca Mastracci, Valentina Angerilli, Emanuele Damiano Urso, Francesca Bergamo, Matteo Fassan
Article
Pathology
Federica Miglietta, Valentina Carraro, Ottavia Amato, Gaia Griguolo, Michele Bottosso, Giada Munari, Giovanni Zarrilli, Marcello Lo Mele, Caterina Barbieri, Angelo Paolo Dei Tos, Valentina Guarneri, Maria Vittoria Dieci, Matteo Fassan
Summary: This study aims to track the dynamics of the PI3K/PTEN/mTOR pathway in HR+/HER2- breast cancer patients receiving neoadjuvant chemotherapy. The results show that this pathway is highly dynamic and may play a crucial role in shaping the molecular landscape of breast cancer with residual disease after chemotherapy.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Pathology
Valentina Angerilli, Paola Parente, Michela Campora, Clara Ugolini, Serena Battista, Paola Cassoni, Alessandro Gambella, Francesco Cavallin, Giuseppe De Lisi, Alessandro Vanoli, Federica Grillo, Luca Mastracci, Matteo Fassan
Summary: In this study, the clinicopathological and molecular features of HER2-low gastric/gastro-oesophageal junction cancers were investigated. It was found that HER2-low expression was more common in biopsy specimens and varied among different institutions. If further research confirms the effectiveness of novel anti-HER2 agents in HER2-low gastro-oesophageal cancers, the interpretation of HER2 status may need to be revised.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Sibilla Molon, Paola Brun, Melania Scarpa, Dario Bizzotto, Gaia Zuccolotto, Marco Scarpa, Matteo Fassan, Imerio Angriman, Antonio Rosato, Paola Braghetta, Ignazio Castagliuolo, Paolo Bonaldo
Summary: The study investigates the role of collagen VI in the development of intestinal inflammation and finds that it plays an important role in lymphatic vessel development and intestinal inflammation. The study also reveals that high collagen VI expression in the colon biopsies of CD patients is associated with increased surgical risk and disease recurrence.
JOURNAL OF PATHOLOGY
(2023)
Correction
Biotechnology & Applied Microbiology
Sergei Yakneen, Sebastian M. Waszak, Michael Gertz, Jan O. Korbel
NATURE BIOTECHNOLOGY
(2023)
Article
Genetics & Heredity
Andrea Remo, Federica Grillo, Luca Mastracci, Michele Simbolo, Matteo Fassan, Maria Paola Cecchini, Giuseppe Miscio, Antonio Sassano, Paola Parente, Alessandro Vanoli, Giovanna Sabella, Guido Giordano, Emanuele Damiano Urso, Luigi Cerulo, Aldo Scarpa, Francesco Fiorica, Massimo Pancione
Summary: A recent study explores the genetic and immunophenotypic characteristics of rhabdoid colorectal tumors (RCTs). The findings reveal that RCTs exhibit mismatch repair-deficient phenotypes, CK7-/CK20-/CDX2- marker phenotype, and aberrant activation of the MAPK pathway, particularly with BRAF V600E mutations. While SMARCB1/INI1 expression is normal, the ciliogenic markers CROCC and β-tubulin are globally altered in RCTs. Overall, these results indicate that primary ciliogenesis and MAPK pathway activation contribute to the aggressiveness of RCTs, suggesting a potential therapeutic target.
Review
Oncology
Astghik Stepanyan, Matteo Fassan, Gaya Spolverato, Ignazio Castagliuolo, Melania Scarpa, Marco Scarpa, IMMUNOREACT Study Grp
Summary: Neoadjuvant therapy (NT) followed by surgery is the main treatment for rectal cancer patients. Immune biomarkers are being recognized as potential predictors of NT response. A meta-analysis was performed to estimate their predictive significance.
Article
Oncology
Ottavia De Simoni, Luca Dal Santo, Marco Scarpa, Giada Munari, Ylenia Camilla Spolverato, Antonio Scapinello, Sara Lonardi, Caterina Solda, Francesca Bergamo, Alberto Fantin, Romeo Bardini, Pierluigi Pilati, Matteo Fassan, Mario Gruppo
Summary: The aim of this study is to determine the potential significant tumor microenvironment (TME) immune markers of long-term survival in pancreatic ductal adenocarcinoma (PDAC) patients. Immunohistochemical staining was performed to characterize the TME using tissue microarray. The results showed that high density of CD8+ lymphocytes and low density of FOXP3+ and iNOS+ tumor-associated macrophages (TAMs) are predictors of good prognosis in PDAC patients.
Article
Pathology
Remo Alessandris, Federico Moroso, Mauro Michelotto, Matteo Fassan, Valentina Angerilli, Linda Callegari, Mirto Foletto
Summary: The use of preoperative upper gastrointestinal endoscopy and postoperative histopathological examination in bariatric surgery is still controversial. Based on the clinical experience of the authors, both preoperative endoscopic assessment and postoperative histopathological examination of the specimen are recommended to provide optimal treatment for these patients.
Review
Pathology
Valentina Angerilli, Matteo Fassan, Paola Parente, Irene Gullo, Michela Campora, Chiara Rossi, Maria Luisa Sacramento, Gianmaria Pennelli, Alessandro Vanoli, Federica Grillo, Luca Mastracci
Summary: PD-L1 is an established immunohistochemical biomarker for predicting the response to immunotherapy. However, it still has limitations due to changing cut-off values and scoring systems, as well as variability between observers and laboratories. This review focuses on the staining patterns and challenges in evaluating PD-L1 in gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma.
Review
Pathology
Valentina Angerilli, Lorenzo Fornaro, Francesco Pepe, Silvia Maria Rossi, Giuseppe Perrone, Umberto Malapelle, Matteo Fassan
Summary: Cholangiocarcinoma (CCA) is a heterogeneous group of neoplasms with a poor prognosis. FGFR2 fusions/rearrangements are druggable genetic alterations in a subset of CCAs. Standardization of molecular testing for FGFR2 alterations in CCA is necessary with the emergence of FGFR-targeting therapies.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)