Review
Biochemistry & Molecular Biology
Martina Morchio, Emanuele Sher, David A. Collier, Daniel W. Lambert, Fiona M. Boissonade
Summary: Neuropathic pain is a highly prevalent condition that affects approximately 8% of the adult population in the UK. The underlying pathophysiology is complex and involves various processes, such as altered neuronal excitability, dysregulated intracellular signaling, and activation of immune and glial cells. Over the past 15 years, miRNAs have emerged as important regulators in neuropathic pain development, acting through the modulation of mRNA translation. Animal studies have identified several miRNAs involved in different stages of nociceptive pathways, but the translation of these findings to human subjects with neuropathic pain is still limited and dependent on the specific etiology. Further research using human tissue and liquid samples may provide valuable insights into miRNAs as diagnostic biomarkers or potential therapeutic targets for neuropathic pain.
Review
Genetics & Heredity
Huan Chen, Guoping Xie, Qunying Luo, Yisha Yang, Siheng Hu
Summary: Breast cancer is a complex disease with unregulated proliferative activity, and dysregulation of cell cycle modulators is a driving factor. In recent years, non-coding RNAs, including miRNAs, circRNAs, and lncRNAs, have been found to play important roles in cell cycle regulation. Understanding the precise roles and mechanisms of these non-coding RNAs could lead to new strategies for diagnosing and treating breast cancer.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Review
Cell Biology
Derong Xu, Xuexiao Ma, Chong Sun, Jialuo Han, Chuanli Zhou, Matthew T. V. Chan, William K. K. Wu
Summary: Neuropathic pain, caused by diseases or injuries of the somatosensory nervous system, affects about 10% of the general population. circRNAs have been found to play key roles in the pathogenesis of neuropathic pain, offering potential for diagnostic, prognostic, and therapeutic applications in clinical management.
CELL PROLIFERATION
(2021)
Review
Behavioral Sciences
Yi-Li Zheng, Jia-Bao Guo, Ge Song, Zheng Yang, Xuan Su, Pei-Jie Chen, Xue-Qiang Wang
Summary: This review discusses the characteristics and functions of circRNAs in neuropathic pain. Through the review of emerging evidence, it is found that deregulation of circRNAs is involved in the development of neuropathic pain and they can modulate downstream gene expression by sponging miRNAs. These findings provide a theoretical basis for the use of circRNAs as biomarkers and therapeutic targets in neuropathic pain.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Cell Biology
Yuhao Lin, Qiqi Sun, Bao Zhang, Wei Zhao, Chenguang Shen
Summary: COVID-19 is a global endemic with severe illness and fatalities. Non-coding RNAs play crucial roles in viral infection and anti-viral immune response, including regulating the expression of antiviral genes and helping the virus evade the immune system. This review summarizes recent research on long non-coding RNAs and microRNAs in SARS-CoV-2 infection and antiviral response, discusses potential mechanisms, and provides insights for detection, treatment, prevention, and future directions of research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mehrdad Hashemi, Mohsen Rashidi, Kiavash Hushmandi, Timo L. M. ten Hagen, Shokooh Salimimoghadam, Afshin Taheriazam, Maliheh Entezari, Mojtaba Falahati
Summary: HMGA2 is a protein that regulates chromatin structure in the nucleus and aberrant expression of this protein is observed in carcinogenesis. It plays a role in various cancer hallmarks and targets key signaling pathways in cancer cells. The interaction between HMGA2 and miRNAs, as well as the regulation of this axis by lncRNAs and circRNAs, is discussed in this review. Additionally, the effect of miRNA and HMGA2 interactions on cancer cell therapy response is examined.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Xin Shi, Panpan Li, Xiang Wu, Jun Shu
Summary: This study compared the gene expression profiles of normal individuals, patients with lumbar disc herniation (LDH), and patients with adult degenerative scoliosis (ADS). Key non-coding RNAs (ncRNAs) associated with the development of ADS were identified, and a regulatory network between ncRNAs and mRNAs was constructed. These findings are important for understanding the pathogenesis of ADS.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Yu-Ying Zhao, Zi-Jun Wu, Li-Juan Zhu, Tong-Xiang Niu, Bin Liu, Jing Li
Summary: Neuropathic pain, resulting from damage to the somatosensory nervous system, is a worldwide clinical condition with significant economic and public health burdens. Neurogenic inflammation and neuroinflammation have been found to play a role in the development of neuropathic pain. Altered miRNA expression profiles are involved in the pathogenesis of inflammatory and neuropathic pain by regulating neuroinflammation, nerve regeneration, and abnormal ion channel expression. The study of exosomal miRNA has contributed to our understanding of the pathophysiology of neuropathic pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Anesthesiology
Marc A. Russo, Ralf Baron, Anthony H. Dickenson, Kai-Uwe Kern, Danielle M. Santarelli
Summary: Ambroxol is a versatile drug with multiple therapeutic actions, including mucoactive, secretolytic, anti-inflammatory, antioxidant, and local anesthetic properties. It has a long history of use in respiratory diseases and has shown efficacy in relieving sore throat. Recent research has focused on its potential for neuropathic pain treatment, despite slow progress. Ambroxol is an inhibitor of Na(v)1.8, an important player in neuropathic pain, and Na(v)1.7, a promising target for chronic pain treatment. This review discusses its analgesic mechanisms, synergistic properties, preclinical and clinical results in managing persistent pain and neuropathic pain symptoms. It is a safe drug with extensive data, encouraging further investigation for repurposing, and urging the pharmaceutical industry to develop optimized formulations for neuropathic pain.
Article
Biochemistry & Molecular Biology
Ioana Maria Maier, Adrian Cornel Maier
Summary: Numerous studies have explored the mechanism and manifestation of endometriosis, highlighting the need for non-invasive diagnostic methods like miRNAs and lncRNAs to diagnose the condition early and alleviate patient suffering. Multiple clinical trials suggest that miRNA can serve as a non-invasive diagnostic tool for differentiating endometriosis stages.
Review
Chemistry, Multidisciplinary
Shanshan Liu, Benzheng Jiao, Hongguang Zhao, Xinyue Liang, Fengyan Jin, Xiaodong Liu, Ji-Fan Hu
Summary: Lipid metabolic reprogramming plays a crucial role in cancer, and dysregulated non-coding RNAs, especially lncRNAs and circRNAs, are involved in the regulation of this process. Understanding their regulatory targets and mechanisms is important for identifying new therapeutic targets and treatment strategies for cancer patients with lipid metabolic reprogramming.
Article
Immunology
Xiaolan Chen, Zhijun Wang, Yangfeng Chen, Ibrahim Akinci, Wei Luo, Yibin Xu, Endashaw Jebessa, Damer Blake, Nick Sparks, Olivier Hanotte, Qinghua Nie
Summary: In this study, the expression patterns of circRNAs, miRNAs, and mRNAs in spleens from Eimeria tenella-infected and non-infected chickens were analyzed using RNA-seq. The results showed differential expression of circRNAs, miRNAs, and mRNAs, and regulatory networks were constructed to investigate the interaction mechanisms between chickens and Eimeria spp. Additionally, functional validation revealed that circMGAT5 may inhibit the activation of macrophages through the circMGAT5-miR-132c-5p-MMD axis during Eimeria infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tianyi Wang, Liu Liu, Dongzhe Song, Dingming Huang
Summary: This review summarizes the role of long noncoding RNAs (lncRNAs) in the pathogenesis, diagnosis, and treatment of trigeminal neuralgia (TN). Recent studies have identified potential lncRNA loci for the diagnosis and treatment of TN. It is suggested that the current diagnostic system could be improved by selecting transcriptomic biomarkers and developing lncRNA-based molecular diagnostic systems for TN. However, further studies are needed to test the diagnostic and therapeutic value of lncRNAs in TN.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Wenxiao Jiang, Shuya Pan, Xin Chen, Zhi-wei Wang, Xueqiong Zhu
Summary: The focus of the study is on understanding the regulatory roles of long noncoding RNAs and circular RNAs in the PD-1/PD-L1 pathway, in hopes of driving more precise and effective cancer immune checkpoint therapies.
Article
Genetics & Heredity
Jie Wang, Meigui Wang, Jiahao Shao, Zheliang Liu, Chong Fu, Guanhe Chen, Kaisen Zhao, Hong Li, Wenqiang Sun, Xianbo Jia, Shiyi Chen, Songjia Lai
Summary: This study investigated the impact of a high-fat diet on lncRNA and miRNA expression in rabbit liver tissues, revealing potential regulatory pathways related to lipid metabolism. The findings provide insights into hepatic steatosis in rabbits and highlight the relevance of CeRNA regulatory networks.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Liuzhu Zhou, Ling Cai, Hongjie Ruan, Li Zhang, Jun Wang, Huijun Jiang, Yuan Wu, Shanwu Feng, Jin Chen
Summary: Burn injuries pose significant burdens on public health, requiring efficacious antibacterial wound-healing dressings. The PCL-COS-Qe/Ru nanofiber membranes demonstrated superior antioxidant and antibacterial activities, showing great potential as ideal options for treating burn injuries.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medical Laboratory Technology
Yuru Fan, Chong Fan, Pengyuan Mao, Can Rui, Xinyan Wang, Wenwen Hou, Ting Luan, Zhiyong Dong, Ping Li, Shanwu Feng, Xin Zeng
Summary: The study evaluated the impact of intrapartum fever on patients, showing that it may affect blood parameters. Intrapartum fever may not only be caused by infection, and differences in white blood cells, red blood cells, and hemoglobin before and after childbirth were significant.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Neurosciences
Jing Wang, Feng Zhou, Susu Zhang, Mao Mao, Shanwu Feng, Xian Wang
Summary: This study demonstrates that duloxetine (DUL) can alleviate chemotherapy-induced peripheral neuropathic pain by suppressing the upregulation of transient receptor potential vanilloid 1 (TRPV1), reducing the release of calcitonin gene-related peptide (CGRP) and substance P (SP), and mitigating the activation of spinal cord glia and expression of tumor necrosis factor-alpha (TNF-alpha).
NEUROSCIENCE LETTERS
(2022)
Article
Microbiology
Zhiyong Dong, Chong Fan, Wenwen Hou, Can Rui, Xinyan Wang, Yuru Fan, Ling Zhao, Qing Wang, Zhichong Wang, Xin Zeng, Shanwu Feng, Ping Li
Summary: This study successfully established a mouse model of vaginal Candida albicans infection and found that the infection can inhibit placental development and lead to adverse pregnancy outcomes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Neurosciences
Yazhou Wen, Shanwu Feng, Hongyu Dai, Meng Mao, Zhenhui Zhou, Bin Li, Chaoran Wang, Xuechun Cai, Shuming Li, Jiaojiao Yang, Quan Ren, Jie Sun
Summary: The study found that surgery/anesthesia caused an imbalance in intestinal flora, leading to neurocognitive impairment, increased the number of Th17 cells in various organs, and elevated levels of IL17, IL17R, and inflammatory factors in the hippocampus. Administration of antibiotics before surgery/anesthesia significantly reduced Th17 cell numbers, IL17 levels, IL17R levels, and inflammatory factor production, thereby improving memory function.
NEUROSCIENCE LETTERS
(2022)
Article
Pharmacology & Pharmacy
Ping Zhu, Ling Cai, Qiao Liu, Shanwu Feng, Hongjie Ruan, Li Zhang, Liuzhu Zhou, Huijun Jiang, Hongsheng Wang, Jianming Wang, Jin Chen
Summary: Nowadays, finding efficient and safe bactericidal agents to combat pathogenic infections is crucial. In this study, a simple method for preparing mesoporous silica nanoparticles using α-Linolenic acid (α-LA) nano-emulsion as a template was developed. The obtained nanoparticles showed apparent antibacterial effect against Staphylococcus aureus and outstanding antimycobacterial activity against drug-sensitive and drug-resistant Mycobacterium tuberculosis when encapsulating Rifampicin. This study provides a promising approach to tackle drug-resistant infectious microbes.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Clinical Neurology
Ming Jiang, Qianqian Li, Mingjie Mao, Chenyang Xu, Rongrong Zhou, Yazhou Wen, Hongmei Yuan, Shanwu Feng
Summary: This study investigated whether Esketamine could alleviate postoperative depression symptoms in patients with missed miscarriages who underwent painless curettage. The results showed that Esketamine effectively treated postoperative depressive symptoms, decreased propofol consumption, and reduced inflammatory response.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Yunyun Sun, Jun Zhang, ShanWu Feng
Summary: The objective of this study was to evaluate the effects of remimazolam supplemented to combined general anesthesia on stress and cognitive performance in elder patients who underwent hip surgery. The results showed that remimazolam supplementation significantly improved heart rate and SpO2 levels, and effectively reduced stress levels and cognitive dysfunction.
PSYCHIATRY INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Huiying Zhang, Hongmei Yuan, Huiling Yu, Yue Zhang, Shanwu Feng
Summary: The combination of pleth variability index (PVI) and inferior vena cava-collapsibility index (IVC-CI) has correlation and consistency in cesarean delivery in twin pregnancies. PVI is a valuable predictor of cesarean delivery volume in twin pregnancies.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Cell Biology
Xiaoyun Sun, Yuying Shen, Muhuo Ji, Shanwu Feng, Yuzhu Gao, Jianjun Yang, Jinchun Shen
Summary: Frailty is identified as an independent risk factor for one-year mortality in elderly patients undergoing elective orthopedic surgery, and should be routinely assessed in preoperative practice.
Article
Neurosciences
Feng Zhou, Xian Wang, Baoyu Han, Xiaohui Tang, Ru Liu, Qing Ji, Zhiqiang Zhou, Lidong Zhang
Summary: Microglia activation and subsequent pro-inflammatory responses are key players in the development of neuropathic pain. Recent studies have shown that the gut microbiota can promote microglial maturation and inflammatory capabilities through the production of SCFAs. Antibiotic treatment may offer a new approach to treating neuropathic pain by reducing SCFAs production and inhibiting microglial polarization.
Review
Biochemistry & Molecular Biology
Shaolei Ma, Changsheng Xu, Shijiang Liu, Xiaodi Sun, Renqi Li, Mingjie Mao, Shanwu Feng, Xian Wang
Summary: Current clinical trials suggest that corticosteroid use may reduce overall mortality in severe COVID-19 patients, decrease disease progression, and not increase the incidence of serious adverse events. However, more trials are needed to confirm these results.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
