The efficacy of receptor tyrosine kinase EphA2 autophosphorylation increases with EphA2 oligomer size
出版年份 2022 全文链接
标题
The efficacy of receptor tyrosine kinase EphA2 autophosphorylation increases with EphA2 oligomer size
作者
关键词
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出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume -, Issue -, Pages 102370
出版商
Elsevier BV
发表日期
2022-08-13
DOI
10.1016/j.jbc.2022.102370
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling
- (2022) Maricel Gomez-Soler et al. iScience
- Oncogenic functions and therapeutic targeting of EphA2 in cancer
- (2021) Kalin Wilson et al. ONCOGENE
- Fluorescence intensity fluctuation analysis of receptor oligomerization in membrane domains
- (2021) Gabriel Biener et al. BIOPHYSICAL JOURNAL
- Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker
- (2021) Bernhard C. Lechtenberg et al. Nature Communications
- Resolving Membrane Protein–Protein Interactions in Live Cells with Pulsed Interleaved Excitation Fluorescence Cross-Correlation Spectroscopy
- (2020) Shaun Christie et al. ACCOUNTS OF CHEMICAL RESEARCH
- Quantifying the strength of heterointeractions among receptor tyrosine kinases from different subfamilies: Implications for cell signaling
- (2020) Michael D Paul et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads
- (2020) Gemma E. Mudd et al. JOURNAL OF MEDICINAL CHEMISTRY
- Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers
- (2020) Toon Verheyen et al. NUCLEIC ACIDS RESEARCH
- Probing membrane protein association using concentration‐dependent Number and Brightness
- (2020) Kalina Hristova et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The Biased Ligands NGF and NT-3 Differentially Stabilize Trk-A Dimers
- (2020) Fozia Ahmed et al. BIOPHYSICAL JOURNAL
- Fluorescence-based Methods for the Study of Protein-Protein Interactions Modulated by Ligand Binding
- (2020) Michael R. Stoneman et al. CURRENT PHARMACEUTICAL DESIGN
- Biased Receptor Signaling in Drug Discovery
- (2019) Terry Kenakin PHARMACOLOGICAL REVIEWS
- Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling
- (2019) Maricel Gomez-Soler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A general method to quantify ligand-driven oligomerization from fluorescence-based images
- (2019) Michael R. Stoneman et al. NATURE METHODS
- Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide–Drug Conjugate
- (2018) Ahmed F. Salem et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell
- (2018) Luca Gambini et al. ACS Chemical Biology
- Signaling bias in drug discovery
- (2017) Terry Kenakin Expert Opinion on Drug Discovery
- A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation
- (2017) Terry Kenakin MOLECULAR PHARMACOLOGY
- A small peptide promotes EphA2 kinase-dependent signaling by stabilizing EphA2 dimers
- (2016) Deo R. Singh et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Fully quantified spectral imaging reveals in vivo membrane protein interactions
- (2016) Christopher King et al. Integrative Biology
- EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
- (2016) Sarah R. Needham et al. Nature Communications
- Molecular basis for multimerization in the activation of the epidermal growth factor receptor
- (2016) Yongjian Huang et al. eLife
- Characterization of Membrane Protein Interactions in Plasma Membrane Derived Vesicles with Quantitative Imaging Förster Resonance Energy Transfer
- (2015) Sarvenaz Sarabipour et al. ACCOUNTS OF CHEMICAL RESEARCH
- Eph Receptors and Ephrins: Therapeutic Opportunities
- (2015) Antonio Barquilla et al. Annual Review of Pharmacology and Toxicology
- Targeting the Eph System with Peptides and Peptide Conjugates
- (2015) Stefan Riedl et al. CURRENT DRUG TARGETS
- Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor
- (2014) Ilaria Lamberto et al. ACS Chemical Biology
- EphA2 and Src regulate equatorial cell morphogenesis during lens development
- (2013) C. Cheng et al. DEVELOPMENT
- Structurally encoded intraclass differences in EphA clusters drive distinct cell responses
- (2013) Elena Seiradake et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor
- (2013) Srinivas Duggineni et al. ACS Medicinal Chemistry Letters
- Eph/Ephrin Signaling in Injury and Inflammation
- (2012) Mark G. Coulthard et al. AMERICAN JOURNAL OF PATHOLOGY
- SLIC Superpixels Compared to State-of-the-Art Superpixel Methods
- (2012) R. Achanta et al. IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
- Alteration of the EphA2/Ephrin-A Signaling Axis in Psoriatic Epidermis
- (2012) Kristin Gordon et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Ephs and ephrins resurface in inflammation, immunity, and atherosclerosis
- (2012) Steven Daniel Funk et al. PHARMACOLOGICAL RESEARCH
- A Simple Method for Quantifying Functional Selectivity and Agonist Bias
- (2011) Terry Kenakin et al. ACS Chemical Neuroscience
- EphA2 Receptor Activation by Monomeric Ephrin-A1 on Supported Membranes
- (2011) Qian Xu et al. BIOPHYSICAL JOURNAL
- Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae
- (2011) Bidisha Sinha et al. CELL
- Inactivation of EphA2 promotes tight junction formation and impairs angiogenesis in brain endothelial cells
- (2011) Na Zhou et al. MICROVASCULAR RESEARCH
- Quantifying Ligand Bias at Seven-Transmembrane Receptors
- (2011) S. Rajagopal et al. MOLECULAR PHARMACOLOGY
- Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis
- (2011) A. G. Godin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Eph receptors with peptides and small molecules: Progress and challenges
- (2011) Roberta Noberini et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells
- (2010) Nai-Ying Yang et al. CELLULAR SIGNALLING
- An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly
- (2010) Elena Seiradake et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Distribution of resting and ligand-bound ErbB1 and ErbB2 receptor tyrosine kinases in living cells using number and brightness analysis
- (2010) P. Nagy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Architecture of Eph receptor clusters
- (2010) J. P. Himanen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt
- (2009) Hui Miao et al. CANCER CELL
- Mutations of theEPHA2receptor tyrosine kinase gene cause autosomal dominant congenital cataract
- (2009) Tianxiao Zhang et al. HUMAN MUTATION
- Mapping the Number of Molecules and Brightness in the Laser Scanning Microscope
- (2007) Michelle A. Digman et al. BIOPHYSICAL JOURNAL
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