Review
Multidisciplinary Sciences
Soheil Hassanipour, Morteza Arab-Zozani, Bahman Amani, Forough Heidarzad, Mohammad Fathalipour, Rudolph Martinez-de-Hoyo
Summary: The meta-analysis of Favipiravir in the treatment of COVID-19 showed significant clinical improvement in the Favipiravir group compared to the control group after seven days of hospitalization. However, there was no significant difference in viral clearance and oxygen therapy requirement between the two groups. The mortality rate was approximately 30% lower in the Favipiravir group, but this finding was not statistically significant.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Jiaxin Chen, Yuangui Cai, Yicong Chen, Anthony P. Williams, Yifang Gao, Jinsheng Zeng
Summary: The study found that NMAEs (nervous and muscular adverse events) after COVID-19 vaccination are common, particularly headache and myalgia. Although these adverse events are mostly mild reactions, continuous monitoring is still necessary during the vaccination process.
Review
Medicine, General & Internal
Julia W. Haas, Friederike L. Bender, Sarah Ballou, John M. Kelley, Marcel Wilhelm, Franklin G. Miller, Winfried Rief, Ted J. Kaptchuk
Summary: This systematic review and meta-analysis found that significantly more adverse events (AEs) were reported in the vaccine groups compared with the placebo groups, but the rates of reported AEs in the placebo arms were still substantial. Public vaccination programs should take into account the high rates of AEs in placebo arms.
Review
Medicine, General & Internal
Jiayu Wen, Quanxian Liu, Daoyan Tang, Jian-Qing He
Summary: Based on a systematic review and meta-analysis of published randomized controlled trials, the effectiveness of Bacillus Calmette-Guerin (BCG) vaccination in preventing COVID-19 infection and severe disease is inconclusive. The rates of infection, hospitalization, ICU admission, and mortality did not differ significantly between the BCG vaccination group and the control group. Current evidence does not support the use of BCG vaccination for COVID-19 prevention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Ali Pormohammad, Mohammad Zarei, Saied Ghorbani, Mehdi Mohammadi, Mohammad Hossein Razizadeh, Diana L. Turner, Raymond J. Turner
Summary: This study systematically reviewed the clinical features of COVID-19 vaccines in clinical trials, finding that mRNA-based and adenovirus-vectored vaccines exhibited different efficacy and side effect profiles. Both types of vaccines showed high efficacy after the first and second doses, with mRNA-based vaccines having higher reported side effects.
Review
Immunology
Hamidreza Kouhpayeh, Hossein Ansari
Summary: This study evaluated the safety and efficacy of COVID-19 vaccines. The results showed that mRNA vaccines are associated with a higher risk of adverse events following immunization. However, currently all types of vaccines still have greater benefits, and vaccination is highly recommended.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shaolei Ma, Changsheng Xu, Shijiang Liu, Xiaodi Sun, Renqi Li, Mingjie Mao, Shanwu Feng, Xian Wang
Summary: Current clinical trials suggest that corticosteroid use may reduce overall mortality in severe COVID-19 patients, decrease disease progression, and not increase the incidence of serious adverse events. However, more trials are needed to confirm these results.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Infectious Diseases
Shinya Tsuzuki, Kayoko Hayakawa, Yohei Doi, Tomohiro Shinozaki, Yukari Uemura, Nobuaki Matsunaga, Mari Terada, Setsuko Suzuki, Yusuke Asai, Gen Yamada, Sho Saito, Taro Shibata, Masashi Kondo, Kazuo Izumi, Masayuki Hojo, Tetsuya Mizoue, Kazuhisa Yokota, Fukumi Nakamura-Uchiyama, Fumitake Saito, Wataru Sugiura, Norio Ohmagari
Summary: This study evaluated the effectiveness of favipiravir on nonsevere, early-stage COVID-19 patients using a nationwide registry. The results showed that favipiravir did not have a positive effect on the clinical outcome of these patients, suggesting that it is not an essential drug for COVID-19 treatment.
INFECTIOUS DISEASES AND THERAPY
(2022)
Review
Pharmacology & Pharmacy
Hongfei Zhu, Mengting Li, Chen Tian, Honghao Lai, Yuqing Zhang, Jiaheng Shi, Nannan Shi, Hui Zhao, Kehu Yang, Hongcai Shang, Xin Sun, Jie Liu, Long Ge, Luqi Huang
Summary: Through a systematic review of randomized controlled trials and observational studies, this study found that Chinese herbal medicine (CHM) treatment is effective and safe for mild/moderate COVID-19 patients. CHM treatment can reduce the conversion rate to severe cases and mortality, shorten the time to symptom resolution, length of hospital stay, and time to viral clearance, and increase the rate of nucleic acid conversion.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Mayur Murali, Leher Gumber, Hannah Jethwa, Divolka Ganesh, Jamie Hartmann-Boyce, Harpreet Sood, Francesco Zaccardi, Kamlesh Khunti
Summary: This study aimed to assess the representation of ethnic groups in UK-based COVID-19 randomised controlled trials (RCTs). The findings revealed that Asian, Black, and Mixed ethnic groups are under-represented or incorrectly classified in UK COVID-19 RCTs. These findings may not apply outside of the UK setting.
Article
Dermatology
P. Punyaratabandhu, S. Vanitchpongphan
Summary: The study found that Favipiravir (FVP) may induce cutaneous adverse reactions in COVID-19 patients. Clinicians should be aware of this potential drug-related allergy and exclude it as a cause of rash during FVP treatment for COVID-19.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Medicine, General & Internal
Xiaolong Zong, Xiao Wang, Yaru Liu, Zhenyu Li, Weiding Wang, Dianjun Wei, Zhuqing Chen
Summary: This study conducted a systematic review and meta-analysis to assess the efficacy of antiplatelet therapy for the treatment of COVID-19. The results showed that antiplatelet treatment may reduce the risk of mortality in COVID-19 patients, but the evidence from randomized controlled trials did not support the use of antiplatelet therapy in standard care.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mojtaba Shohan, Roohangiz Nashibi, Mohammad-Reza Mahmoudian-Sani, Farhad Abolnezhadian, Mehri Ghafourian, Seyed Mohammad Alavi, Asaad Sharhani, Ali Khodadadi
Summary: This study evaluated the therapeutic efficacy of quercetin in combination with remdesivir and favipiravir in severe hospitalized COVID-19 patients. Quercetin was found to prevent disease progression and reduce inflammatory markers related to SARS-Cov-2 pathogenesis. However, the impact on mortality and ICU-admission duration was not significant.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Infectious Diseases
Pinyo Rattanaumpawan, Supunnee Jirajariyavej, Kanokorn Lerdlamyong, Nattawan Palavutitotai, Jatuporn Saiyarin
Summary: This retrospective observational study in Thailand found that favipiravir showed promising effectiveness in treating hospitalized COVID-19 patients. Older age, higher baseline NEWS2 score, and lower loading dose of favipiravir were identified as poor prognostic factors for early clinical improvement.
Review
Infectious Diseases
Fangyuan Tian, Qiyi Feng, Zhaoyan Chen
Summary: This study aimed to evaluate the efficacy and safety of molnupiravir in the treatment of COVID-19. The meta-analysis results showed that molnupiravir can accelerate the rehabilitation of COVID-19 patients, but it does not significantly reduce mortality and hospitalisation.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Sport Sciences
Linh Tran, Abdelrahman M. Makram, Omar Mohamed Makram, Muhammed Khaled Elfaituri, Sara Morsy, Sherief Ghozy, Ahmed Helmy Zayan, Nguyen Hai Nam, Marwa Mostafa Mohamed Zaki, Elizabeth L. Allison, Truong Hong Hieu, Loc Le Quang, Dang The Hung, Nguyen Tien Huy
Summary: This systematic review and meta-analysis found that Kinesio taping can significantly improve pain and disability in musculoskeletal disorders. Regardless of the body region, application of Kinesio taping for the first five days and four-to-six weeks resulted in efficacy.
RESEARCH IN SPORTS MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Yusuke Kimura, Yukinori Koyama, Kojiro Taura, Aoi Kudoh, Kanae Echizen, Daichi Nakamura, Xuefeng Li, Nguyen Hai Nam, Yusuke Uemoto, Takahiro Nishio, Gen Yamamoto, Satoru Seo, Keiko Iwaisako, Akira Watanabe, Etsuro Hatano
Summary: This study aimed to investigate the role of collagen gene expressing hepatic cells in liver regeneration following partial hepatectomy (PH). The analysis of collagen gene expressing cells revealed the presence of distinct hepatic stellate cell clusters during liver regeneration, with these cells promoting the regeneration process.
Review
Gastroenterology & Hepatology
Randa Elsheikh, Hoang Thuy Tien, Abdelrahman M. Makram, Nguyen Thanh Van, Trang Thi Bich Le, Tamilarasy Vasanthakumaran, Nguyen Tien Huy
Summary: Since April 2022, there has been a rapidly spreading outbreak of acute hepatitis of unknown origin in children under 16 years old in multiple countries. Adenovirus serotype 41 has been identified as the most likely cause of the disease. However, further investigations are being carried out to explain the severity of the clinical presentation, which is not typical for this type of virus.
Review
Pharmacology & Pharmacy
Dao Ngoc Hien Tam, Nguyen Hai Nam, Nguyen The Ky Cuong, Dang The Hung, Dang Thi Soa, Ahmad Altom, Linh Tran, Heba Elhadad, Nguyen Tien Huy
Summary: This study aimed to systematically review the anticancer effects of compound K (CK). Fifty-four articles were included in the review, and the results showed that CK had potential anticancer activity in in vitro and in vivo studies, inhibiting various cancer cell lines. In mice models, there was a significant decrease in tumor volume after CK treatment. CK could be a potential supplementary treatment in cancer chemotherapies, but further safety assessments and clinical trials are needed for drug development.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Psychiatry
Ho Nguyen Yen Phi, Truong Quoc Tho, Bui Xuan Manh, Tran Anh Ngoc, Pham Thi Minh Chau, Nguyen Trung Nghia, Tran Trung Nghia, Huynh Ho Ngoc Quynh, Nguyen Tien Huy, Ngo Tich Linh, Pham Le An
Summary: This study identified a high prevalence of depressive disorders in primary care clinics in Ho Chi Minh City, Vietnam, but a low recognition rate by general practitioners.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
(2023)
Letter
Virology
Nguyen K. Quan, Dang H. Thien, Nguyen T. Huy
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Vu Thi Thu Trang, Le Van Truong, Truong Van Dat, Randa Elsheikh, Nguyen Tuan Anh, Dang Xuan Thang, Vo Viet Thang, Abdelrahman M. Makram, Nguyen Tien Huy, Nagasaki University Collaborative
Summary: The study aimed to assess the impact of Ho Chi Minh City's policy to delay the second dose of the COVID-19 vaccine on the equal provision of healthcare. The results showed that holding the second dose of the vaccine was associated with a lower risk of low oxygen saturation. Therefore, governments should consider adopting this approach for greater community benefit.
Article
Immunology
Le Thi Thuy Hang, Hoang Kim Tu Trinh, Luong Bac An, Nguyen Thi Tuyet, Phan Vinh Tho, Nguyen Tien Huy, Pham Thi Le Hoa
Summary: This study observed the percentages and mRNA levels of regulatory T (Treg) and T helper 17 (Th17) cells in patients with chronic hepatitis B virus (HBV) infection. The results showed that these cells were significantly increased in severe hepatitis flare cases. This finding highlights the importance of these cells in the immune response to HBV.
Article
Public, Environmental & Occupational Health
Venkata Vasavi Vadduri, Ayako Toyokawa, Nguyen Ngoc Hoang Linh, Dang Nguyen, Jeza M. Abdul Aziz, Norio Ohmagari, Nguyen Tien Huy
PATHOGENS AND GLOBAL HEALTH
(2023)
Article
Medicine, General & Internal
Mahmoud A. Hafez, Fouad Zamel, Tarek El-Khadrawi, Ibrahim El Ganzoury, Abdel M. Lotfy, Maher Fansa, Abdelrahman M. Makram
Summary: This study reviewed the rate and management of prosthetic joint infection (PJI) in Egypt based on the Egyptian Community Arthroplasty Registry (ECAR) and data from six arthroplasty surgeons. Out of 5216 total hip and knee arthroplasties (THA and TKA), the overall infection rate was 4.03% with a higher rate in THA. Staphylococcus aureus was the most common organism and vancomycin was commonly used as the antibiotic. The study emphasizes the importance of improving operating theater design and infection control education to reduce infection rates, as well as the need for a national arthroplasty registry.
ANNALS OF MEDICINE AND SURGERY
(2023)
Letter
Infectious Diseases
Marcel Alied, Patricia Takako Endo, Victor Hugo Aquino, Venkata Vasavi Vadduri, Nguyen Tien Huy
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Nasreen G. Majeed, Shakhawan A. Mustafa, Abdelrahman M. Makram, Paxshan A. Mohammed, Jeza M. Abdul Aziz, Mina M. Mansour, Dilsoz M. Qadir, Ali T. Arif, Maryam B. Mahmmod, Mariwan K. Rasheed, Nguyen Tien Huy
Summary: This study aimed to identify the factors that may influence obstetricians' decisions regarding cesarean sections. The results showed that most obstetricians supported non-medically indicated cesarean sections and believed that women have the right to choose their mode of delivery. However, there were differences in attitudes among obstetricians, and some faced lawsuits for refusing to perform cesarean sections. Factors influencing obstetricians' acceptance of non-medically indicated cesarean sections included unsure or refused responses from the doctors, doctors who do not frequently perform cesarean sections, and those who refuse to perform them being more likely to agree that women have the right to request cesarean sections.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Pediatrics
Mohammed Abdellatif, Gehad Mohamed Tawfik, Abdelrahman M. Makram, Mostafa Khaled Abdelsattar, Monica Dobs, Dimitrios N. Papadopoulos, Bao-Long Hoang-Trong, Esraa Mahmoud Mostafa, Pham Diep Thuy Duong, Nguyen Tien Huy
Summary: Phototherapy may be associated with an increased risk of future cancer, particularly hematopoietic cancers and leukemia. Further research is needed to confirm this risk, especially when considering premature infants.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Health Care Sciences & Services
Truong Van Dat, Vo Linh Tu, Nguyen Khoi Quan, Nguyen Hong Minh, Tran Dinh Trung, Tran Nhat Le, Dang Phuc-Vinh, Dieu-Thuong Thi Trinh, Luyen Pham Dinh, Hai-Yen Nguyen-Thi, Nguyen Tien Huy
Summary: Telepharmacy, as a delivery of pharmacy care using telecommunication technologies, has been proven effective in addressing pharmacist shortages and facilitating safe medication administration in underserved areas. It also has the potential to drive innovation in the healthcare industry.
TELEMEDICINE AND E-HEALTH
(2023)
