Modulation of Microglia M2 Polarization and Alleviation of Hippocampal Neuron Injury By MiR-106b-5p/RGMa in a Mouse Model of Status Epilepticus

Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson’s disease

(2021) Wakana Oda et al.   Cell Death & Disease

miR-106b-5p upregulation is associated with microglial activation and inflammation in the mouse hippocampus following status epilepticus

(2021) Tao Yu et al.   EXPERIMENTAL BRAIN RESEARCH

Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity

(2020) Peravina Therajaran et al.   EPILEPSIA

miR-106b-5p induces immune imbalance of Treg/Th17 in immune thrombocytopenic purpura through NR4A3/Foxp3 pathway

(2020) Jian-Qin Li et al.   CELL CYCLE

MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia

(2020) Ioanna Plastira et al.   Journal of Neuroinflammation

Blueberry Counteracts BV-2 Microglia Morphological and Functional Switch after LPS Challenge

(2020) Maria Giovanna De Caris et al.   Nutrients

Circular RNA Circ_ANKMY2 Regulates Temporal Lobe Epilepsy Progression via the miR-106b-5p/FOXP1 Axis

(2020) Qing Lin et al.   NEUROCHEMICAL RESEARCH

Circular RNA circ_DROSHA alleviates the neural damage in a cell model of temporal lobe epilepsy through regulating miR-106b-5p/MEF2C axis

(2020) Donglin Zheng et al.   CELLULAR SIGNALLING

Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway

(2019) Qing Liu et al.   Journal of Neuroinflammation

Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A

(2019) Andreas Körner et al.   Nature Communications

Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice

(2019) Xinjian Zhu et al.   Frontiers in Cellular Neuroscience

Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model

(2019) Yijun Shen et al.   BRAIN BEHAVIOR AND IMMUNITY

microRNA‐132 is overexpressed in glia in temporal lobe epilepsy and reduces the expression of pro‐epileptogenic factors in human cultured astrocytes

(2019) Anatoly Korotkov et al.   GLIA

Biomarkers For Epileptogenesis And Its Treatment

(2019) Jerome Engel et al.   NEUROPHARMACOLOGY

Emerging Roles for Microglial Phagocytic Signaling in Epilepsy

(2019) Season K. Wyatt-Johnson et al.   Epilepsy Currents

Synaptic Pruning by Microglia in Epilepsy

(2019) Megumi Andoh et al.   Journal of Clinical Medicine

Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury

(2018) Hiroshi Nakagawa et al.   CEREBRAL CORTEX

Inflammation and Epilepsy: Preclinical Findings and Potential Clinical Translation

(2018) Gaetano Terrone et al.   CURRENT PHARMACEUTICAL DESIGN

The primary prevention of epilepsy: A report of the Prevention Task Force of the International League Against Epilepsy

(2018) David J. Thurman et al.   EPILEPSIA

Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis

(2018) A. J. Becker   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica

(2018) Kana Harada et al.   Scientific Reports

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

(2018) Xiaofeng Zhao et al.   Cell Reports

The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis

(2018) Linda Kalilani et al.   EPILEPSIA

Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis

(2018) Shogo Tanabe et al.   Cell Death & Disease

Anxiety and depressive disorders in people with epilepsy: A meta-analysis

(2017) Amelia J. Scott et al.   EPILEPSIA

MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C/EBP-α pathway in intracerebral hemorrhage

(2017) Anyong Yu et al.   IMMUNOLOGY LETTERS

Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease

(2017) Joanna A. Korecka et al.   JOURNAL OF NEUROSCIENCE

Downregulation of miR-106b attenuates inflammatory responses and joint damage in collagen-induced arthritis

(2017) Yunxia Tao et al.   RHEUMATOLOGY

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling

(2017) Christian Siebold et al.   TRENDS IN CELL BIOLOGY

Elevated serum miR-106b and miR-146a in patients with focal and generalized epilepsy

(2016) Ning An et al.   EPILEPSY RESEARCH

Microglia engulf viable newborn cells in the epileptic dentate gyrus

(2016) Cong Luo et al.   GLIA

A novel role for RGMa in modulation of bone marrow-derived dendritic cells maturation induced by lipopolysaccharide

(2016) Xuxu Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress

(2016) Pengfei Li et al.   MOLECULAR NEUROBIOLOGY

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Prevalence and incidence of epilepsy

(2016) Kirsten M. Fiest et al.   NEUROLOGY

Kangxian capsules: Effects on convulsive injuries, N -methyl- d -aspartate (NMDA) receptor subunit expression, and free Ca 2+ concentration in a rat hippocampal neuron epileptic discharge model

(2016) Xian-Qing Ren et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models

(2015) Melissa J. Benson et al.   EPILEPSIA

P2Y6 Receptor-Mediated Microglial Phagocytosis in Radiation-Induced Brain Injury

(2015) Yongteng Xu et al.   MOLECULAR NEUROBIOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Immunity and Inflammation in Epilepsy

(2015) Annamaria Vezzani et al.   Cold Spring Harbor Perspectives in Medicine

Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP-stimulated microglia

(2014) Anna-Karin Persson et al.   GLIA

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Repulsive Guidance Molecule-a Is Involved in Th17-Cell-Induced Neurodegeneration in Autoimmune Encephalomyelitis

(2014) Shogo Tanabe et al.   Cell Reports

Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures

(2012) Jayne Abraham et al.   NEUROBIOLOGY OF DISEASE

Depression and epilepsy: A bidirectional relation?

(2011) Andres M. Kanner   EPILEPSIA

RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis

(2011) Rieko Muramatsu et al.   NATURE MEDICINE

Refractory Epilepsy Associated With Microglial Activation

(2011) Souhel Najjar et al.   NEUROLOGIST

Comorbidity between epilepsy and depression: Experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms

(2010) Eduardo Pineda et al.   EPILEPSIA

Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy

(2010) E. Aronica et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

MAPK Signal Transduction Underlying Brain Inflammation and Gliosis as Therapeutic Target

(2009) Bozena Kaminska et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Emerging roles for neogenin and its ligands in CNS development

(2008) Melissa De Vries et al.   JOURNAL OF NEUROCHEMISTRY

S100B/RAGE-dependent activation of microglia via NF-κB and AP-1

(2008) Roberta Bianchi et al.   NEUROBIOLOGY OF AGING