Galunisertib attenuates progression of trauma-induced heterotopic ossification via blockage of Smad2/3 signaling in mice
出版年份 2022 全文链接
标题
Galunisertib attenuates progression of trauma-induced heterotopic ossification via blockage of Smad2/3 signaling in mice
作者
关键词
-
出版物
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 928, Issue -, Pages 175109
出版商
Elsevier BV
发表日期
2022-06-20
DOI
10.1016/j.ejphar.2022.175109
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma
- (2020) Antje Wick et al. INVESTIGATIONAL NEW DRUGS
- Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
- (2020) Michael Sorkin et al. Nature Communications
- βig-h3 enhances chondrogenesis via promoting mesenchymal condensation in rat Achilles tendon heterotopic ossification model
- (2020) Qiang Zhang et al. Aging-US
- Heterotopic ossification of tendon and ligament
- (2020) Qiang Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- TGF-β Signaling
- (2020) Kalliopi Tzavlaki et al. Biomolecules
- Matrine attenuates heterotopic ossification by suppressing TGF-β induced mesenchymal stromal cell migration and osteogenic differentiation
- (2020) Dong Mao et al. BIOMEDICINE & PHARMACOTHERAPY
- TGF-β1 plays a protective role in glucocorticoid-induced dystrophic calcification
- (2020) La Li et al. BONE
- Small molecule inhibition of non-canonical (TAK1-mediated) BMP signaling results in reduced chondrogenic ossification and heterotopic ossification in a rat model of blast-associated combat-related lower limb trauma
- (2020) Amy L. Strong et al. BONE
- A Phase 2 Study of Galunisertib (TGF-β1 Receptor Type I Inhibitor) and Sorafenib in Patients With Advanced Hepatocellular Carcinoma
- (2019) R.K. Kelley et al. Clinical and Translational Gastroenterology
- Phase 2 Study of the ALK5 Inhibitor Galunisertib in Very Low-, Low-, and Intermediate-Risk Myelodysplastic Syndromes
- (2019) Valeria Santini et al. CLINICAL CANCER RESEARCH
- Celecoxib cannot inhibit the progression of initiated traumatic heterotopic ossification
- (2019) Fengfeng Li et al. JOURNAL OF SHOULDER AND ELBOW SURGERY
- Appropriate excision time of heterotopic ossification in elbow caused by trauma
- (2018) Shu-Kun He et al. Acta Orthopaedica et Traumatologica Turcica
- Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP)
- (2018) Tracy A. Brennan et al. BONE
- Aberrant TGF-β activation in bone tendon insertion induces enthesopathy-like disease
- (2018) Xiao Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
- (2018) Xiao Wang et al. Nature Communications
- Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva
- (2018) John B. Lees-Shepard et al. Nature Communications
- Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
- (2018) Sofia Ferreira-Gonzalez et al. Nature Communications
- Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity
- (2018) John B Lees-Shepard et al. eLife
- Failure of Indomethacin and Radiation to Prevent Blast-induced Heterotopic Ossification in a Sprague-Dawley Rat Model
- (2018) Astor D. Robertson et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC1 signaling
- (2017) Huaji Jiang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The traumatic bone: trauma-induced heterotopic ossification
- (2017) Devaveena Dey et al. Translational Research
- Inhibition of TGFβ signaling decreases osteogenic differentiation of fibrodysplasia ossificans progressiva fibroblasts in a novel in vitro model of the disease
- (2016) Dimitra Micha et al. BONE
- Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model
- (2016) Gabriel J. Pavey et al. BONE
- Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis
- (2016) Hidetsugu Suzuki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon
- (2016) Shailesh Agarwal et al. STEM CELLS
- Heterotopic Ossification
- (2015) Kavitha Ranganathan et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Effects of celecoxib on proliferation and tenocytic differentiation of tendon-derived stem cells
- (2014) Kairui Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Transforming Growth Factor- as a Therapeutic Target in Hepatocellular Carcinoma
- (2014) G. Giannelli et al. CANCER RESEARCH
- First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma
- (2014) Jordi Rodon et al. CLINICAL CANCER RESEARCH
- Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer
- (2014) Jordi Rodón et al. INVESTIGATIONAL NEW DRUGS
- Tendon Progenitor Cells in Injured Tendons Have Strong Chondrogenic Potential: The CD105-Negative Subpopulation Induces Chondrogenic Degeneration
- (2014) Shuji Asai et al. STEM CELLS
- TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
- (2013) Neil E. Bhola et al. JOURNAL OF CLINICAL INVESTIGATION
- Tendon mineralization is accelerated bilaterally and creep of contralateral tendons is increased after unilateral needle injury of murine achilles tendons
- (2013) Etienne John Ogilvy O'Brien et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Heterotopic mineralization (ossification or calcification) in tendinopathy or following surgical tendon trauma
- (2012) Etienne J. O. O'Brien et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Heterotopic Ossification in Orthopaedic Trauma
- (2012) Aaron Nauth et al. JOURNAL OF ORTHOPAEDIC TRAUMA
- BMP-2 mediates PGE2-induced reduction of proliferation and osteogenic differentiation of human tendon stem cells
- (2011) Jianying Zhang et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists
- (2011) Kengo Shimono et al. NATURE MEDICINE
- Insights from a rare genetic disorder of extra-skeletal bone formation, fibrodysplasia ossificans progressiva (FOP)
- (2008) Eileen M. Shore et al. BONE
- Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)
- (2008) Frederick S. Kaplan et al. JOURNAL OF BONE AND MINERAL METABOLISM
- BMP type I receptor inhibition reduces heterotopic ossification
- (2008) Paul B Yu et al. NATURE MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started