期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 525, 期 2, 页码 380-388出版社
WILEY-BLACKWELL
DOI: 10.1002/cne.24070
关键词
axon regeneration; naked mole-rat; retinal ganglion cell; axon injury; axon growth. RRID: IMSR_JAX:000664; RRID: AB_10063408; RRID: AB_143165; RRID: AB_10694681; RRID: AB_2532994; RRID: AB_561305; RRID: AB_2534074; RRID: AB_143165; RRID: AB_2535855
资金
- NEI NIH HHS [R01 EY022961] Funding Source: Medline
In the adult mammalian central nervous system (CNS), axonal damage often triggers neuronal cell death and glial activation, with very limited spontaneous axon regeneration. In this study, we performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maximum life span exceeding 30 years, and found that injury responses in this species are quite distinct from those in other mammalian species. In contrast to what is seen in other mammals, the majority of injured retinal ganglion cells (RGCs) survive with relatively high spontaneous axon regeneration. Furthermore, injured RGCs display activated signal transducer and activator of transcription-3 (STAT3), whereas astrocytes in the optic nerve robustly occupy and fill the lesion area days after injury. These neuronintrinsic and -extrinsic injury responses are reminiscent of those in cold-blooded animals, such as fish and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mechanisms of neuronal injury responses and axon regeneration in mammals. (C) 2016 Wiley Periodicals, Inc.
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