期刊
EUROPEAN JOURNAL OF HAEMATOLOGY
卷 109, 期 5, 页码 576-585出版社
WILEY
DOI: 10.1111/ejh.13845
关键词
CALR; CHIP; clonal haematopoiesis of indeterminate potential; eGFR; epidemiology; impaired kidney function; population studies
类别
资金
- A.V. Lykfeldt and Wife's Scholarship
- Aase and Ejnar Danielsen's Foundation
- Anders Hasselbalch's Foundation Fighting Leukemia
- Candys Foundation
- Carpenter Joergen Holm and Wife Elisa F. Hansen's Memorial Foundation
- Dagmar Marshalls Fond
- Else and Mogens Wedell-Wedellborgs Foundation
- Eva and Henry Fraenkels Memorial Foundation
- Johan and Lise Boserup Foundation
- Johannes Fog's Foundation
- Manufacturer Einar Willumsens Memorial Foundation
- Naestved Hospital
- Naestved Hospital Foundation
- Naestved Municipality
- Region Zealand
- Hoejmosegaard Scholarship
- Local Government Denmark Foundation
- National Board of Health
- Region Zealand Research Foundation
- TrygFonden
- Lundbeck Foundation Fellowship
The relationship between clonal haematopoiesis of indeterminate potential (CHIP) and impaired kidney function is unclear. A study in Denmark found that individuals with CALR mutations, especially CALR type 2, had impaired kidney function compared to those without CHIP.
The myeloproliferative neoplasms are associated with chronic kidney disease but whether clonal haematopoiesis of indeterminate potential (CHIP) is associated with impaired kidney function is unknown. In the Danish General Suburban Population Study (N = 19 958) from 2010 to 2013, 645 individuals were positive for JAK2V617F (N = 613) or CALR (N = 32) mutations. Mutation-positive individuals without haematological malignancy were defined as having CHIP (N = 629). We used multiple and inverse probability weighted (IPW)-adjusted linear regression analysis to estimate adjusted mean (95% confidence interval) differences in estimated glomerular filtration rate (eGFR; ml/min/1.73 m(2)) by mutation status, variant allele frequency (VAF%), blood cell counts, and neutrophil-to-lymphocyte ratio (NLR). We performed 11-year longitudinal follow-up of eGFR in all individuals. Compared to CHIP-negative individuals, the mean differences in eGFR were -5.6 (-10.3, -0.8, p = .02) for CALR, -11.9 (-21.4, -2.4, p = 0.01) for CALR type 2, and -10.1 (-18.1, -2.2, p = .01) for CALR with VAF >= 1%. The IPW-adjusted linear regression analyses showed similar results. NLR was negatively associated with eGFR. Individuals with CALR type 2 had a worse 11-year longitudinal follow-up on eGFR compared to CHIP-negative individuals (p = .004). In conclusion, individuals with CALR mutations, especially CALR type 2, had impaired kidney function compared to CHIP-negative individuals as measured by a lower eGFR at baseline and during 11-year follow-up.
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