Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis

Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation

(2022) Shengchen Wang et al.   Redox Biology

Long-term exposure of the Mediterranean mussels, Mytilus galloprovincialis to polyethylene terephthalate microfibers: Implication for reproductive and neurotoxic effects

(2022) Jin Soo Choi et al.   CHEMOSPHERE

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Environmentally relevant concentrations of microplastics influence the locomotor activity of aquatic biota

(2021) Tao Sun et al.   JOURNAL OF HAZARDOUS MATERIALS

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

(2021) Jiucui Li et al.   Journal of Translational Medicine

The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice

(2021) Yung-Li Wang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene

(2021) Yu Wang et al.   ENVIRONMENTAL POLLUTION

ROS-Induced Hepatotoxicity under Cypermethrin: Involvement of the Crosstalk between Nrf2/Keap1 and NF-κB/iκB-α Pathways Regulated by Proteasome

(2021) Hongjing Zhao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB signal pathway

(2021) Nao Yan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Studying microplastics: Lessons from evaluated literature on animal model organisms and experimental approaches

(2021) Marko D. Prokić et al.   JOURNAL OF HAZARDOUS MATERIALS

Microplastics in soil: A review on methods, occurrence, sources, and potential risk

(2021) Ling Yang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: Long-term exposure as a potential risk for male reproductive health

(2021) Jing-Bo Liu et al.   ENVIRONMENT INTERNATIONAL

Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress

(2021) Zhong-Gui Gong et al.   JOURNAL OF HAZARDOUS MATERIALS

Organochlorine pesticides, polycyclic aromatic hydrocarbons, metals and metalloids in microplastics found in regurgitated pellets of black vulture from Campeche, Mexico

(2021) Merle M. Borges-Ramírez et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Microplastic-induced apoptosis and metabolism responses in marine Dinoflagellate, Karenia mikimotoi

(2021) Ting Zhao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Long-term exposure to polyethylene microplastics and glyphosate interferes with the behavior, intestinal microbial homeostasis, and metabolites of the common carp (Cyprinus carpio L.)

(2021) Jianjun Chen et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure

(2020) Sreeja Sarasamma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death

(2020) Yang Liu et al.   CANCER GENE THERAPY

Are we underestimating microplastic abundance in the marine environment? A comparison of microplastic capture with nets of different mesh-size

(2020) Penelope K. Lindeque et al.   ENVIRONMENTAL POLLUTION

High density polyethylene (HDPE) microplastics impair development and swimming activity of Pacific oyster D-larvae, Crassostrea gigas, depending on particle size

(2020) Arno Bringer et al.   ENVIRONMENTAL POLLUTION

Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus Larvae

(2020) Hui Yang et al.   JOURNAL OF HAZARDOUS MATERIALS

Exposure to microplastics impairs digestive performance, stimulates immune response and induces microbiota dysbiosis in the gut of juvenile guppy (Poecilia reticulata)

(2020) Jun-Nan Huang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Microplastics entering northwestern Lake Ontario are diverse and linked to urban sources

(2020) Jelena Grbić et al.   WATER RESEARCH

BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis

(2020) Young-Sun Lee et al.   APOPTOSIS

Zebrafish: An emerging model to study microplastic and nanoplastic toxicity

(2020) Jacky Bhagat et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

Microplastic accumulation in the gastrointestinal tracts in birds of prey in central Florida, USA

(2020) Julia Carlin et al.   ENVIRONMENTAL POLLUTION

Toxicological effects of nano- and micro-polystyrene plastics on red tilapia: Are larger plastic particles more harmless?

(2020) Jiannan Ding et al.   JOURNAL OF HAZARDOUS MATERIALS

Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy

(2020) Christopher F. Rose et al.   JOURNAL OF HEPATOLOGY

A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis

(2020) Zuli Wang et al.   MOLECULAR THERAPY

Environmentally relevant concentration of Cypermethrin or/and Sulfamethoxazole induce neurotoxicity of grass carp:involvement of blood-brain barrier, oxidative stress and apoptosis

(2020) Hongjing Zhao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Breeding seabirds as vectors of microplastics from sea to land: Evidence from colonies in Arctic Canada

(2020) Madelaine P.T. Bourdages et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Zinc offers splenic protection through suppressing PERK/IRE1-driven apoptosis pathway in common carp (Cyprinus carpio) under arsenic stress

(2020) Yu Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation

(2020) Yuehong Wang et al.   CELLULAR SIGNALLING

Microplastics in the diet of nestling double-crested cormorants (Phalacrocorax auratus), an obligate piscivore in a freshwater ecosystem

(2019) Cole B. Brookson et al.   CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Is plastic ingestion in birds as toxic as we think? Insights from a plastic feeding experiment

(2019) Lauren Roman et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Molecular mechanisms of ferroptosis and its role in cancer therapy

(2019) Tao Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Microplastics and the gut microbiome: How chronically exposed species may suffer from gut dysbiosis

(2019) Gloria Fackelmann et al.   MARINE POLLUTION BULLETIN

Hydrogen sulfide exposure induces apoptosis and necroptosis through lncRNA3037/miR-15a/BCL2-A20 signaling in broiler trachea

(2019) Xiaojing Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Ammonia regulates chicken tracheal cell necroptosis via the LncRNA-107053293/MiR-148a-3p/FAF1 axis

(2019) Wei Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

Atmospheric microplastic deposition in an urban environment and an evaluation of transport

(2019) S.L. Wright et al.   ENVIRONMENT INTERNATIONAL

Evaluation of microplastic toxicity in accordance with different sizes and exposure times in the marine copepod Tigriopus japonicus

(2019) Jin Soo Choi et al.   MARINE ENVIRONMENTAL RESEARCH

Freshwater microplastics pollution: Detecting and visualizing emerging trends based on Citespace II

(2019) Liming Yao et al.   CHEMOSPHERE

Neuroprotective effects of Dendropanax morbifera leaves on glutamate-induced oxidative cell death in HT22 mouse hippocampal neuronal cells

(2019) Hye-Jin Park et al.   JOURNAL OF ETHNOPHARMACOLOGY

Partial least squares-discriminant analysis (PLS-DA) for classification of high-dimensional (HD) data: a review of contemporary practice strategies and knowledge gaps

(2018) Loong Chuen Lee et al.   ANALYST

Accumulation of polystyrene microplastics in juvenile Eriocheir sinensis and oxidative stress effects in the liver

(2018) Ping Yu et al.   AQUATIC TOXICOLOGY

Why do so many genetic insults lead to Purkinje Cell degeneration and spinocerebellar ataxia?

(2018) Miaozhen Huang et al.   NEUROSCIENCE LETTERS

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid storage and lipophagy regulates ferroptosis

(2018) Yuansong Bai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway

(2018) Zhaoyan Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

(2018) Vinicius Cruzat et al.   Nutrients

Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice

(2018) Yuanxiang Jin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

miR+Pathway: the integration and visualization of miRNA and KEGG pathways

(2018) Cong Pian et al.   BRIEFINGS IN BIOINFORMATICS

Microplastics in freshwater and terrestrial environments: Evaluating the current understanding to identify the knowledge gaps and future research priorities

(2017) Alice A. Horton et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Brain damage and behavioural disorders in fish induced by plastic nanoparticles delivered through the food chain

(2017) Karin Mattsson et al.   Scientific Reports

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Cerebrospinal fluid metabolomics highlights dysregulation of energy metabolism in overt hepatic encephalopathy

(2016) Nicolas Weiss et al.   JOURNAL OF HEPATOLOGY

Cellular and circuit mechanisms underlying spinocerebellar ataxias

(2016) Pratap Meera et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Nonalcoholic fatty liver disease is associated with cognitive function in adults

(2016) Sang Won Seo et al.   NEUROLOGY

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Circuit Mechanisms Underlying Motor Memory Formation in the Cerebellum

(2015) Ka Hung Lee et al.   NEURON

Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function

(2015) LIANGYU CHEN et al.   ONCOLOGY REPORTS

Threat of plastic pollution to seabirds is global, pervasive, and increasing

(2015) Chris Wilcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte glutamine synthetase: pivotal in health and disease

(2015) Christopher F. Rose et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation

(2014) B. H. Mullish et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Altered Behavior, Physiology, and Metabolism in Fish Exposed to Polystyrene Nanoparticles

(2014) Karin Mattsson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Deranged Calcium Signaling in Purkinje Cells and Pathogenesis in Spinocerebellar Ataxia 2 (SCA2) and Other Ataxias

(2010) Adebimpe Kasumu et al.   CEREBELLUM

The blood-brain barrier and glutamate

(2009) Richard A Hawkins   AMERICAN JOURNAL OF CLINICAL NUTRITION