期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 483, 期 -, 页码 201-210出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2016.08.038
关键词
Polysarcosine; Hydrophilic polypeptide; Nanomaterials; Long circulation
资金
- National Key Research Program of China [2016YFB0700804]
- Key Science Technology Innovation Team of Zhejiang Province [2013TD02]
- National Natural Science Foundation of China [51120135001, 21528402]
- State Key Laboratory of Molecular Engineering of Polymers (Fudan University)
- Fundamental Research Funds for the Central Universities [2016QNA4030]
Polysarcosine (PS), a non-ionic hydrophilic polypeptoid whose structure is similar to polypeptides, bearing repeating units of natural alpha-amino acid, has been used to stabilize gold nanoparticles (AuNPs) due to its excellent hydrophilicity and biocompatibility. Disulfide functionalized polysarcosines with different molecular weight were synthesized and used to cap AuNPs by traditional ligand exchange. The grafting of PS on AuNPs was evidenced by Fourier transform infrared (FTIR) spectroscopy and the alternation of surface zeta potential. The polysarcosine coated AuNPs (Au@PS) showed good stabilities in wide pH range and saline condition. They had strong resistance to ligand competition of dithiothreitol (DTT). They showed good stability in serum, with a molecular weight dependent interaction pattern with proteins. The Au@PS had very low cytotoxicity and cell uptake in vitro. Based on the results in vitro, polysarcosine with molecular weight of 5 kD with the best ability to stabilize AuNPs was used for in vivo test. The Au@PS had a longer circulation time in blood after intravenous injection than that of Au@PEG, indicating a better stealth-like property of polysarcosine. The Au@PS did not cause obvious toxicity in vivo, suggesting potential applications in disease diagnosis and therapy. (C) 2016 Elsevier Inc. All rights reserved.
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