Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061

A highly conserved pocket on PP2A‐B56 is required for hSgo1 binding and cohesion protection during mitosis

(2021) Yumi Ueki et al.   EMBO REPORTS

Druggable cancer phosphatases

(2021) Julia P. Vainonen et al.   Science Translational Medicine

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

(2021) Tia A. Tummino et al.   SCIENCE

Comprehensive Evaluation of a Quantitative Shotgun Lipidomics Platform for Mammalian Sample Analysis on a High-Resolution Mass Spectrometer

(2020) Inger Ødum Nielsen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

(2020) Ken Morita et al.   CELL

Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy

(2020) Jukka Westermarck et al.   CELL

Selective PP2A Enhancement through Biased Heterotrimer Stabilization

(2020) Daniel Leonard et al.   CELL

A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

(2020) Xinru Wang et al.   eLife

Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins

(2020) Yulia Steblyanko et al.   EMBO JOURNAL

Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry

(2020) Isha Nasa et al.   Science Signaling

Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

(2019) Gang Zhang et al.   EMBO JOURNAL

Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis

(2019) Shanhui Liao et al.   CELL RESEARCH

Identifying chemogenetic interactions from CRISPR screens with drugZ

(2019) Medina Colic et al.   Genome Medicine

Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer

(2018) Otto Kauko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeted therapies don't work for a reason; the neglected tumor suppressor phosphatase PP2A strikes back

(2018) Jukka Westermarck   FEBS Journal

A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans

(2018) Scott P Lyons et al.   MOLECULAR & CELLULAR PROTEOMICS

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

(2018) Michal Zimmermann et al.   NATURE

Protein phosphatases in the regulation of mitosis

(2018) Jakob Nilsson   JOURNAL OF CELL BIOLOGY

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

(2017) Jaya Sangodkar et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

(2017) Marco Jost et al.   MOLECULAR CELL

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

(2017) Traver Hart et al.   G3-Genes Genomes Genetics

BAGEL: a computational framework for identifying essential genes from pooled library screens

(2016) Traver Hart et al.   BMC BIOINFORMATICS

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit

(2016) Michael J. Cundell et al.   JOURNAL OF CELL BIOLOGY

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

(2016) Emil Peter Thrane Hertz et al.   MOLECULAR CELL

Reengineered tricyclic anti-cancer agents

(2015) David B. Kastrinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

Phenothiazine-Derived Antipsychotic Drugs Inhibit Dynamin and Clathrin-Mediated Endocytosis

(2015) James A. Daniel et al.   TRAFFIC

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Interactions of phenothiazine drugs with surfactants: A detailed physicochemical overview

(2013) Suruchi Mahajan et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression

(2013) T. Kruse et al.   JOURNAL OF CELL SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

γ-Tubulin 2 Nucleates Microtubules and Is Downregulated in Mouse Early Embryogenesis

(2012) Stanislav Vinopal et al.   PLoS One

Comet: An open-source MS/MS sequence database search tool

(2012) Jimmy K. Eng et al.   PROTEOMICS

N-Benzoylated Phenoxazines and Phenothiazines: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization

(2011) Helge Prinz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

MassChroQ: A versatile tool for mass spectrometry quantification

(2011) Benoît Valot et al.   PROTEOMICS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Spindly/CCDC99 Is Required for Efficient Chromosome Congression and Mitotic Checkpoint Regulation

(2010) Marin Barisic et al.   MOLECULAR BIOLOGY OF THE CELL

Direct visualization of phase separation induced by phenothiazine-type antipsychotic drugs in model lipid membranes

(2010) Olga Wesołowska et al.   MOLECULAR MEMBRANE BIOLOGY

The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program

(2010) S Schmidt et al.   ONCOGENE

Structure and Function of the PP2A-Shugoshin Interaction

(2009) Zheng Xu et al.   MOLECULAR CELL

TRAPPC2L is a Novel, Highly Conserved TRAPP-Interacting Protein

(2009) P. James Scrivens et al.   TRAFFIC

Multiple pathways regulated by the tumor suppressor PP2A in transformation

(2008) Jukka Westermarck et al.   TRENDS IN MOLECULAR MEDICINE