UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1

DEF1: Much more than an RNA polymerase degradation factor

(2021) Oluwasegun T. Akinniyi et al.   DNA REPAIR

Transcription-coupled repair and the transcriptional response to UV-Irradiation

(2021) Liam Gaul et al.   DNA REPAIR

Causes and consequences of RNA polymerase II stalling during transcript elongation

(2020) Melvin Noe Gonzalez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Analysis of RNA polymerase II ubiquitylation and proteasomal degradation

(2019) Ana Tufegdzic Vidakovic et al.   METHODS

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

(2019) Diana Zatreanu et al.   MOLECULAR CELL

The Cellular Response to Transcription-Blocking DNA Damage

(2018) Lea H. Gregersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis

(2017) Romain Aucagne et al.   FASEB JOURNAL

Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage

(2017) Juston C. Weems et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes

(2016) Masao Maeda et al.   FASEB JOURNAL

Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses

(2015) Juston C. Weems et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response

(2015) Andrew E.H. Elia et al.   MOLECULAR CELL

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity

(2014) M.-E. Bordeleau et al.   BLOOD

Proteasome-Mediated Processing of Def1, a Critical Step in the Cellular Response to Transcription Stress

(2013) Marcus D. Wilson et al.   CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Ubiquitylation and degradation of elongating RNA polymerase II: The last resort

(2012) Marcus D. Wilson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II

(2011) Rati Verma et al.   MOLECULAR CELL

Evidence that Transcript Cleavage Is Essential for RNA Polymerase II Transcription and Cell Viability

(2010) Stefan Sigurdsson et al.   MOLECULAR CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation

(2009) M. Harreman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1

(2008) Takashi Yasukawa et al.   EMBO JOURNAL