Article
Rehabilitation
Gino S. Panza, Tommy Sutor, Cameron M. Gee, Marnie Graco, Kevin K. McCully, Anthony Chiodo, M. Safwan Badr, Mark S. Nash
Summary: This article emphasizes the importance of considering sleep-disordered breathing as a potential confounder in rehabilitation research interventions for spinal cord injury patients. It highlights the high prevalence of SDB in SCI and the lack of research on its impact on physical rehabilitation in SCI, calling for further studies on the integrated relationship among physical rehabilitation, SDB, and proper treatment in SCI.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Clinical Neurology
Mohammadreza Hajipour, Brett Baumann, Ali Azarbarzin, Hirsch Allen, Yu Liu, Sidney Fels, Sebastian Goodfellow, Amrit Singh, Rachel Jen, Najib T. Ayas
Summary: Polysomnograms (PSGs) collect a wealth of physiologic signals, but these data are often under-utilized in clinical decision making. Recent studies have explored alternative PSG metrics that could better predict outcomes related to obstructive sleep apnea (OSA). We conducted a systematic review to assess the association between alternative PSG metrics and health outcomes in OSA.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Critical Care Medicine
Jeremy E. Orr, Indu Ayappa, Danny J. Eckert, Jack L. Feldman, Chandra L. Jackson, Shahrokh Javaheri, Rami N. Khayat, Jennifer L. Martin, Reena Mehra, Matthew T. Naughton, Winfried J. Randerath, Scott A. Sands, Virend K. Somers, M. Safwan Badr
Summary: The international multidisciplinary group identified 11 specific research priorities regarding central sleep apnea (CSA) in heart failure patients, focusing on areas such as control of breathing, variability across individuals, examination techniques, treatment impact, and implementation strategies. Advancing care for patients with CSA in the context of heart failure will require progress in translational, epidemiological, and patient-centered outcome research. Priority should be given to targeted research to improve knowledge of CSA pathogenesis and treatment, given the increasing prevalence of heart failure and its substantial burden.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Chia-Feng Juang, Chih-Yu Wen, Kai-Ming Chang, Yu-Hsuan Chen, Ming-Feng Wu, Wei-Chang Huang
Summary: The study aimed to propose a self-estimation method for predicting obstructive sleep apnea-hypopnea syndrome (OSAHS) using easy-to-obtain physiological features, and the results showed that the explainable fuzzy neural network (EFNN) was the preferred method for predicting moderate-to-severe OSAHS.
Article
Medicine, General & Internal
Paul Stark, Eric Y. Y. Chang
Summary: We investigated the coexistence of sleep apnea and pulmonary hypertension in a group of Veterans. A retrospective study was conducted on 142 patients with dilated main pulmonary artery. Approximately 40% of patients with pulmonary hypertension also had sleep apnea. There was no significant difference in pulmonary artery diameters between the group without sleep apnea and the group with sleep apnea (34.5 ± 4.2 mm vs. 34.7 ± 4.4 mm, p = 0.373).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Gustavo Guerrero, Virginie Le Rolle, Corinne Loiodice, Amel Amblard, Jean-Louis Pepin, Alfredo Hernandez
Summary: A model-based approach is proposed to analyze the acute desaturation response to obstructive apneas. By analyzing the data from 107 patients, a dynamic model related to sleep apnea was obtained. The study results have potential applications for personalized diagnosis and treatment.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Otorhinolaryngology
Yi Cai, Priyanka Tripuraneni, Arushi Gulati, Erika M. Stephens, Dang-Khoa Nguyen, Megan L. Durr, Jolie L. Chang
Summary: The treatment goals and values of adult patients with obstructive sleep apnea (OSA) vary based on age, symptoms, positive airway pressure (PAP) history, and severity of OSA. Understanding patient-specific goals is crucial in the shared decision-making process when choosing surgical or nonsurgical treatments.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Endocrinology & Metabolism
Emily Jane Meyer, Gary Allen Wittert
Summary: Obstructive sleep apnea (OSA) and obesity are closely associated; OSA is often unrecognized in women; OSA increases the risk of developing comorbid chronic disorders and impairs quality of life; appropriate treatment can improve symptoms and related diseases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Neurosciences
Gonzalo C. Gutierrez-Tobal, Javier Gomez-Pilar, Leila Kheirandish-Gozal, Adrian Martin-Montero, Jesus Poza, Daniel Alvarez, Felix del Campo, David Gozal, Roberto Hornero
Summary: The study demonstrates that as the severity of the disease increases, OSA broadly impacts sleep EEG, making information from different frequency bands more similar. EEG activity and irregularity information is significantly associated with polysomnographic variables in the most severely affected children, indicating disruptions in both micro and macro sleep. Furthermore, relationships between sleep EEG and cognitive scores, particularly in the delta(1) and beta(2) bands, suggest pronounced associations with language, visual-spatial processing, and executive function.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Lu Dai, Wenhao Cao, Jinmei Luo, Rong Huang, Yi Xiao
Summary: This study used the AHI and SBII to assess the severity of OSA and examine their effectiveness in predicting CVD outcomes. Cluster analysis revealed different patient groups with varying symptom complaints and PSG characteristics. SBII was found to be more sensitive in evaluating OSA severity and had better predictive capabilities for CVD outcomes compared to AHI.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Review
Anesthesiology
Crispiana Cozowicz, Stavros G. Memtsoudis
Summary: The prevalence of obstructive sleep apnea (OSA) worldwide has reached 1 billion people, posing significant risks in the perioperative setting. Critical determinants of perioperative risk in OSA patients include changes in upper airway anatomy, diminished upper airway dilator muscle capability, disparities in arousal thresholds, and ventilatory control instability. Preoperative screening, heightened awareness, and postoperative care adjustments are important considerations. Anesthetic agents and sedatives worsen upper airway collapsibility, while the utilization of neuromuscular blockade increases the risk for respiratory compromise. Opioid analgesia is complex in OSA, with patients being prone to opioid-induced respiratory depression along with increased pain sensitivity. Regional anesthesia and multimodal analgesia are recommended to reduce perioperative complications. Health care institutions are allocating resources to enhance patient safety, and evidence-based perioperative management strategies are needed to address the challenges posed by the rising prevalence of OSA and the lack of evidence on the efficacy of costly measures. Screening algorithms, monitoring, and risk predictors are urgently needed for extended postoperative surveillance and care for OSA patients. The perioperative community is faced with the challenge of developing feasible pathways and measures to increase patient safety and prevent complications in patients with OSA.
ANESTHESIA AND ANALGESIA
(2021)
Article
Otorhinolaryngology
Somya Shankar, Annie E. Moroco, Zachary T. Elliott, Maurits Boon, Colin Huntley
Summary: This study retrospectively examined the health outcomes of patients with Trisomy 21 (T21) and obstructive sleep apnea (OSA) 10 years after their diagnosis of OSA. The results showed that patients with T21 and OSA had significantly higher incidence of adverse health outcomes in various cardiovascular, neurological, and endocrinological aspects. Patients who underwent sleep surgery had significantly reduced incidence of adverse health outcomes compared to those using continuous positive airway pressure.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Clinical Neurology
Xia Yang, Yi Wen, Shiqi Xie, Jinglan Chen, Yue Liu, Jianrong Zhou
Summary: This study provides a summary of the main treatment methods, research hotspots, and trends of obstructive sleep apnea (OSA) through bibliometric and visualization analysis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Otorhinolaryngology
Min-Seok Rha, Yeonsu Jeong, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
Summary: This study found that the presence of mixed apnea (MA) events in patients with obstructive sleep apnea (OSA) leads to different clinical characteristics and surgical outcomes. The mixed group had a lower surgical success rate and smaller postoperative improvements in sleep apnea indices compared to the pure group. Logistic regression analysis confirmed that the presence of MA is an independent predictor of poor surgical outcomes in OSA patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Medicine, Research & Experimental
Julianna Rodin, Michele Fiorella, Meghan Crippen, Keisha Best, Daniel Taub, Allen Champion, Maurits Boon, Colin Huntley
Summary: Less than half of patients referred for MMA followed up, and less than half of those patients underwent MMA. Most patients cited concerns about the invasiveness of the surgery and recovery process.