Article
Immunology
Marie Carbonnel, Camille Daclin, Nadine Tarantino, Olivia Groiseau, Veronique Morin, Alice Rousseau, Marc Vasse, Alexandre Hertig, Titouan Kennel, Jean Marc Ayoubi, Vincent Vieillard
Summary: The COVID-19 pandemic affects gestation and pregnancy, and this study highlights the relationship between NK cells, inflammation, and estradiol in patients with ongoing infection. NK cells play a crucial role in fetal immune imprinting, and their characteristics are correlated with inflammatory markers and hormone levels. Additionally, neonates born to infected women have decreased NK cell counts.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Biology
Paola Kucan Brlic, Ilija Brizic
Summary: A new study reveals the impact of SARS-CoV-2 on natural killer cells' ability to recognize and eliminate infected cells.
Article
Immunology
Maren Claus, Naomi Pieris, Doris Urlaub, Peter Broede, Bernhard Schaaf, Deniz Durak, Frank Renken, Carsten Watzl
Summary: The analysis of immunological parameters during a SARS-CoV-2 infection is important for identifying diagnostic markers and understanding the role of the immune system. Using multicolor flow cytometry, NK cells from COVID-19 patients were compared with samples from recovered and naive subjects. The analysis revealed an enrichment of NKG2C expressing NK cells and highly activated NK cell subsets with an exhausted phenotype. NKG2C expressing NK cells are involved in the early innate immune response against SARS-CoV-2.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adina Hutanu, Doina Manu, Manuela Rozalia Gabor, Anca Meda Vasiesiu, Akos Vince Andrejkovits, Minodora Dobreanu
Summary: This study evaluated the dynamic changes of total NK cells and different NK subpopulations in COVID-19 patients based on their differentiated expression of CD16/CD56. The results showed different patterns in NK cell subpopulations between survivors and non-survivors, indicating the diversity of NK cell response during the course of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hans Raskov, Adile Orhan, Ali Salanti, Shruti Gaggar, Ismail Gogenur
Summary: NK cells play a crucial role in cancer treatment by recognizing and killing transformed cells, potentially improving treatment outcomes. Current research focuses on the development of immunotherapeutic approaches, including immune checkpoint inhibitors and adoptive cell transfer using T cells with chimeric antigen receptors to enhance immune function.
Review
Biochemistry & Molecular Biology
Tatiana Michel, Markus Ollert, Jacques Zimmer
Summary: Despite the challenges in cancer treatment, immunotherapy based on NK cells is considered to be one of the most promising options and has already shown success in clinical settings. This review highlights the different possibilities and mechanisms of NK cells in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jiacheng Bi, Chen Huang, Xiaomeng Jin, Chaoyue Zheng, Yingying Huang, Xiaohu Zheng, Zhigang Tian, Haoyu Sun
Summary: By analyzing single-cell transcriptomics and using gene reporter mice, this study found that TIPE2 expression correlated with NK cell exhaustion in the tumor microenvironment (TME) in both humans and mice. Deletion of TIPE2 improved the antitumor activity of adoptively transferred mouse NK cells and human NK cells, either derived from peripheral blood or induced pluripotent stem cells (iPSCs). Additionally, TIPE2 deletion synergized with CISH deletion to further enhance antitumor activity in vivo.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Letter
Oncology
Changqian Bao, Xiandong Tao, Wei Cui, Yuanyuan Hao, Shuaike Zheng, Bin Yi, Tiewen Pan, Ken H. Young, Wenbin Qian
Summary: COVID-19 patients are discharged based on two consecutive negative viral RNA tests, improved respiratory symptoms, and obvious absorption of inflammation in pulmonary imaging. Differences in various blood cell counts and infection-related parameters were found between severe and non-severe groups. Higher counts of certain immune cells were associated with faster clearance of the virus and better outcomes.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Oncology
Nadine Landolina, Francesca Romana Mariotti, Tiziano Ingegnere, Claudia Alicata, Biancamaria Ricci, Andrea Pelosi, Irene Veneziani, Bruno Giuseppe Azzarone, Cecilia Garlanda, Alberto Mantovani, Lorenzo Moretta, Enrico Maggi
Summary: This study aimed to investigate the role of IL-1R8 in human NK cells and optimize its silencing conditions. The results showed that silencing IL-1R8 can enhance the activity and anti-tumor response of NK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Sainiteesh Maddineni, John L. Silberstein, John B. Sunwoo
Summary: This article reviews multiple approaches for allogeneic NK cell therapy and discusses the advantages and disadvantages of each method. In recent years, NK cells have become increasingly important players in the immune response against cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, Research & Experimental
Maria Antonietta Isgro, Maria Grazia Vitale, Egidio Celentano, Flavia Nocerino, Giuseppe Porciello, Marcello Curvietto, Domenico Mallardo, Concetta Montagnese, Luigi Russo, Nicoletta Zanaletti, Antonio Avallone, Matilde Pensabene, Michelino De Laurentiis, Sara Centonze, Sandro Pignata, Lucia Cannella, Alessandro Morabito, Francesco Caponigro, Gerardo Botti, Giuseppe Valentino Masucci, Diana Giannarelli, Ernesta Cavalcanti, Paolo Antonio Ascierto
Summary: This study investigated the proportion of COVID-19 infection among cancer patients and healthcare providers in Naples, Italy, finding a significantly lower positivity rate among patients receiving ICIs treatment, suggesting ICIs treatment may be a protective factor against COVID-19 infection.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Seung Hee Choi, Hye Jin Kim, Joo Dong Park, Eun-Su Ko, Minwook Lee, Dae-Keum Lee, Jin-Ho Choi, Hye Jung Jang, Isaac Kim, Hae-Yun Jung, Keun-Hong Park, Kyung-Soon Park
Summary: The chemical priming of NK cells using 25KbPEI enhances their antitumor activity and migration ability, offering a simple and cost-effective method for producing therapeutic NK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Microbiology
Giovanna Schiuma, Silvia Beltrami, Daria Bortolotti, Sabrina Rizzo, Roberta Rizzo
Summary: A robust innate immune response is crucial for controlling viral infections. Natural Killer (NK) cells, monocytes/macrophages, and neutrophils, which represent the innate immune components, form the first line of defense against the virus. The activation of these components is essential for an effective acquired immune response.
Article
Multidisciplinary Sciences
Jiao Wang, Sandra Toregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia Atallah Lanman, Victor Bernal-Crespo, Matthew M. Behymer, Gregory T. Knipp, Yeonhee Yun, Michael C. Veronesi, Anthony L. Sinn, Karen E. Pollok, Randy R. Brutkiewicz, Kathryn S. Nevel, Sandro Matosevic
Summary: This study demonstrates a promising strategy utilizing genetically engineered human NK cells as a multifunctional immunotherapy to target multiple mechanisms of GBM progression simultaneously, including addressing antigen escape, immunometabolic reprogramming, and immune cell homing.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Genetics & Heredity
Meike Vogler, Senthan Shanmugalingam, Vinzenz Sarchen, Lisa Marie Reindl, Victoria Greze, Leon Buchinger, Michael Kuehn, Evelyn Ullrich
Summary: NK cells play a crucial role in cancer treatment, with their killing capacity determined by signals between NK cells and targeted tumor cells. Combining NK cell therapy with other agents can enhance therapeutic efficacy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Biochemistry & Molecular Biology
Kumaresan Ramanathan, Minale Fekadie, Giri Padmanabhan, Henok Gulilat
Summary: Long noncoding RNAs (lncRNAs) play critical roles in kidney disease development and their dysregulation can lead to various disease processes. Understanding the function and potential application of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities. This review provides an overview of lncRNA characteristics, function, and specific studies related to kidney disease treatment.
CELL BIOCHEMISTRY AND FUNCTION
(2024)