期刊
CARBOHYDRATE POLYMERS
卷 297, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119974
关键词
Zwitterionic skin; Carboxymethyl cellulose; Wound dressings; Monitoring; Antibacterial
资金
- National Natural Science Founda-tion of China [21908160, 22078238, 21961132005]
- Tianjin Natu-ral Science Foundation [20JCQNJC00170]
This study designs a novel cellulose-based hydrogel that can monitor and promote the healing of infected wounds in real time. The hydrogel exhibits pH and temperature responsive properties and can release Ag+ to kill bacteria. This research opens up new possibilities for domestic real-time monitoring and pro-healing of infected wounds.
Wound infection can induce inflammation and impede wound healing, being a major challenge in wound care management. A household device that can monitor infection in real time, prevent bacterial, and promote wound healing is highly desired but still rarely investigated. In this work, a novel zwitterionic cellulose-based hydrogel that enables continuously real-time monitoring and pro-healing of infected wound is designed. It is based on interpenetrating polymeric networks, including zwitterionic covalent bond network and physical bond network of carboxymethyl cellulose (CMC) with Ag+ via metal-coordination interactions. When used as a sensing dressing, it is developed to exhibit pH-responsive and temperature-responsive properties for assessment of wound infection. Moreover, Ag+ can be released from carboxyl groups of CMC in response to the decrease of pH, killing bacteria and promoting wound healing. This zwitterionic carboxymethyl cellulose-based hydrogel sensor opens new avenues for domestic real-time monitoring and pro-healing of infected wound.
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