Arrhythmias Seen in Baseline 24-Hour Holter ECG Recordings in Healthy Normal Volunteers During Phase 1 Clinical Trials

Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase

(2015) B Darpo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Baseline and new-onset morphologic ECG abnormalities in healthy volunteers in phase I studies receiving placebo: Changes over a 6-week follow-up period

(2014) Pooja Hingorani et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The IQ-CSRC Prospective Clinical Phase 1 Study: “Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”

(2013) Borje Darpo et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

Ventricular Arrhythmias in the Absence of Structural Heart Disease

(2012) Eric N. Prystowsky et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Evaluation of ventricular arrhythmias in early clinical pharmacology trials and potential consequences for later development

(2010) Sherene S. Min et al.   AMERICAN HEART JOURNAL

Reducing QT liability and proarrhythmic risk in drug discovery and development

(2010) Jean-Pierre Valentin   BRITISH JOURNAL OF PHARMACOLOGY

Update on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug development

(2009) Vaibhav Salvi et al.   BRITISH JOURNAL OF PHARMACOLOGY