期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 31, 期 8, 页码 1650-1660出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-22-0092
关键词
AMP Exception
资金
- NIH [R01 CA211705]
- NIH [R01 CA211705, U01CA206110, R01CA207371, R01189184]
- German Consortium of Translational Cancer Research (DKTK)
- German Cancer Research Center (Division of Preventive Oncology)
- Stiftung LebensBlicke
- Claussen-Simon Stiftung, Germany
- Huntsman Cancer Foundation
- Matthias Lackas Foundation
- Transcan-ERANET [R01 CA211705]
- [01KT1503]
Cell adhesion molecules and angiogenesis biomarkers are prognostic markers for colorectal cancer, with differences based on tumor site. Tailored treatment strategies are needed for colon and rectal cancer.
Background: Cell-to-cell adhesion and angiogenesis are hallmarks of cancer. No studies have examined associations of adhesion molecules and angiogenesis biomarkers with clinical outcomes in colorectal cancer. Methods: In presurgery serum from n = 426 patients with colorectal cancer (stage I-III), we investigated associations of CRP, SAA, adhesion molecules (sICAM-1, sVCAM-1), and angiogenesis markers (VEGF-A and VEGF-D) with overall survival (OS), disease-free survival (DFS), and risk of recurrence. We computed HRs and 95% confidence intervals; adjusted for age, sex, BMI, stage, site, and study site, stratified by tumor site in exploratory analyses. Results: N = 65 (15%) were deceased, and 39 patients (14%) had a recurrence after a median follow-up of 31 months. We observed significant associations of biomarkers with OS, DFS, and risk of recurrence on a continuous scale and comparing top to bottom tertile, with HRs ranging between 1.19 and 13.92. CRP was asso-ciated with risk of death and recurrence in patients in the top tertile compared with patients in the bottom tertile, for example, risk of recurrence HRQ3-Q1: 13.92 (1.72-112.56). Significant heteroge-neity between biomarkers and clinical outcomes was observed in stratified analysis by tumor site for CRP, SAA, sICAM-1, sVCAM-1, and VEGF-D. VEGF-D was associated with a 3-fold increase in risk of death for rectal cancer (HRlog2: 3.26; 95% CI, 1.58-6.70) compared with no association for colon cancer (HRlog2: 0.78; 95% CI, 0.35-1.73; P-heterogenity = 0.01). Conclusions: Adhesion molecules and angiogenesis biomar-kers are independent prognostic markers for colorectal cancer, with differences by tumor site. Impact: There is need for tailored treatment for colon and rectal cancer.
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