Selexipag in Pulmonary Arterial Hypertension: Most Updated Evidence From Recent Preclinical and Clinical Studies

Pharmacokinetics of the novel oral prostacyclin receptor agonist selexipag in subjects with hepatic or renal impairment

(2016) Priska Kaufmann et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects

(2016) Shirin Bruderer et al.   CLINICAL THERAPEUTICS

Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag

(2015) Priska Kaufmann et al.   American Journal of Cardiovascular Drugs

Effect of lopinavir/ritonavir on the pharmacokinetics of selexipag an oral prostacyclin receptor agonist and its active metabolite in healthy subjects

(2015) Priska Kaufmann et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Bioequivalence of different dose-strength tablets of selexipag, a selective prostacyclin receptor agonist, in a multiple-dose up-titration study

(2015) Daniela Baldoni et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Selexipag for the Treatment of Pulmonary Arterial Hypertension

(2015) Olivier Sitbon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary hypertension: diagnostic and therapeutic challenges

(2015) Wassim Fares et al.   Therapeutics and Clinical Risk Management

Multiple-Dose Up-Titration Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Selexipag, an Orally Available Selective Prostacyclin Receptor Agonist, in Healthy Subjects

(2014) Shirin Bruderer et al.   PHARMACOLOGY

A thorough QT study in the context of an uptitration regimen with selexipag, a selective oral prostacyclin receptor agonist

(2014) Matthias Hoch et al.   Drug Design Development and Therapy

Oral Treprostinil for the Treatment of Pulmonary Arterial Hypertension in Patients Receiving Background Endothelin Receptor Antagonist and Phosphodiesterase Type 5 Inhibitor Therapy (The FREEDOM-C2 Study)

(2013) Victor F. Tapson et al.   CHEST

Efficacy and Safety of Oral Treprostinil Monotherapy for the Treatment of Pulmonary Arterial Hypertension

(2013) Zhi-Cheng Jing et al.   CIRCULATION

Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins

(2013) N.N. Orie et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension

(2012) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Prognostic factors in severe pulmonary hypertension patients who need parenteral prostanoid therapy: The impact of late referral

(2012) Roberto Badagliacca et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Prostacyclins in pulmonary arterial hypertension: the need for earlier therapy

(2011) Jean-Luc Vachiéry   ADVANCES IN THERAPY

Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension

(2011) Md. Talat Nasim et al.   HUMAN MUTATION

Imatinib in Pulmonary Arterial Hypertension Patients with Inadequate Response to Established Therapy

(2010) Hossein A. Ghofrani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

At the heart of tissue: endothelin system and end-organ damage

(2010) Marc Iglarz et al.   CLINICAL SCIENCE

Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study

(2010) H. A. Ghofrani et al.   EUROPEAN RESPIRATORY JOURNAL

Selexipag: A Selective Prostacyclin Receptor Agonist that Does Not Affect Rat Gastric Function

(2010) K. Morrison et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Long-term therapy with inhaled iloprost in patients with pulmonary hypertension

(2010) Horst Olschewski et al.   RESPIRATORY MEDICINE

Tadalafil Therapy for Pulmonary Arterial Hypertension

(2009) Nazzareno Galiè et al.   CIRCULATION

End Points and Clinical Trial Design in Pulmonary Arterial Hypertension

(2009) Vallerie V. McLaughlin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

(2009) Vallerie V. McLaughlin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetics and Genomics of Pulmonary Arterial Hypertension

(2009) Rajiv D. Machado et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diagnosis and Assessment of Pulmonary Arterial Hypertension

(2009) David B. Badesch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension

(2009) Kamal K. Mubarak   RESPIRATORY MEDICINE

Endothelin receptor antagonists in pulmonary arterial hypertension

(2008) J. Dupuis et al.   EUROPEAN RESPIRATORY JOURNAL

Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial

(2008) N Galiè et al.   LANCET