期刊
BRAIN RESEARCH BULLETIN
卷 185, 期 -, 页码 99-106出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2022.04.015
关键词
Obesity; Central nervous system; Hypothalamus; Microinflammation
资金
- National Key Research and Development Program of China [2018YFC1003504]
- National Natural Science Foundation of China [81570774, 82070872, 92049118]
- Junior Thousand Talents Program of China
- Nanjing medical university startup fund
- Jiang Su Innovative and Entrepreneurial talent funding
This review provides an overview of the important role of the hypothalamus in energy metabolism, focusing on the functions of POMC neurons and AgRP neurons in the acute nucleus. It also discusses the impact of high fat diet-induced hypothalamic microinflammation on the pathogenesis of obesity.
Obesity is believed to arise through the imbalance of energy homeostasis controlled by the central nervous system, where the hypothalamus plays the fundamental role in energy metabolism. In this review, we will provide an overview regarding the functions of POMC neurons and AgRP neurons in acute nucleus of the hypothalamus which mediated the energy metabolism, highlighting their interactions with peripheral organs derived hormones in control of energy homeostasis. Furthermore, the role of high fat diet induced hypothalamic microinflammation in the pathogenesis of obesity will be discussed. We hope this review could help researchers to understand the mechanism of hypothalamus in control of energy metabolism, and design related drugs to block the pathways involving in the impaired metabolism in obese patients.
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