Article
Hematology
Gaurav Goyal, Abdellatif Tazi, Ronald S. Go, Karen L. Rech, Jennifer L. Picarsic, Robert Vassallo, Jason R. Young, Christian W. Cox, Jan Van Laar, Michelle L. Hermiston, Xin-Xin Cao, Polyzois Makras, Gregory Kaltsas, Julien Haroche, Matthew Collin, Kenneth L. McClain, Eli L. Diamond, Michael Girschikofsky
Summary: Langerhans cell histiocytosis (LCH) is a disease that can affect children and adults, with various clinical manifestations. Recent research suggests that LCH can be considered as a hematopoietic neoplasm and can be treated with targeted therapies. Therefore, an update of the existing recommendations for the diagnosis and treatment of LCH in adults is necessary. The use of F-18-Fluorodeoxyglucose positron emission tomography-based imaging is recommended for staging and response assessment in most cases. Local therapies may cure unifocal disease, while systemic treatments are recommended for patients with multifocal and multisystem disease. Appropriate management of symptoms such as pain, fatigue, and mood disorders is important.
Editorial Material
Medicine, General & Internal
Rajesh T. Gandhi, Roger Bedimo, Jennifer F. Hoy, Raphael J. Landovitz, Davey M. Smith, Ellen F. Eaton, Clara Lehmann, Sandra A. Springer, Paul E. Sax, Melanie A. Thompson, Constance A. Benson, Susan P. Buchbinder, Carlos del Rio, Joseph J. Eron, Huldrych F. Guenthard, Jean-Michel Molina, Donna M. Jacobsen, Michael S. Saag
Summary: Based on new data, recommendations are provided to clinicians on the use of antiretroviral drugs for the treatment and prevention of HIV, as well as on laboratory monitoring, care of aging individuals with HIV, substance use disorder, and new challenges such as COVID-19 and monkeypox virus infection. The initiation of antiretroviral therapy as soon as possible after HIV diagnosis is recommended, along with addressing barriers to care and ensuring access to medication and adherence support. Advances in treatment and prevention of HIV have improved outcomes, but challenges and opportunities still exist.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Mikel Izquierdo, R. A. Merchant, J. E. Morley, S. D. Anker, I. Aprahamian, H. Arai, M. Aubertin-Leheudre, R. Bernabei, E. L. Cadore, M. Cesari, L. -k. Chen, P. de Souto Barreto, G. Duque, L. Ferrucci, R. A. Fielding, A. Garcia-Hermoso, L. M. Gutierrez-Robledo, S. D. R. Harridge, B. Kirk, S. Kritchevsky, F. Landi, N. Lazarus, F. C. Martin, E. Marzetti, M. Pahor, R. Ramirez-Velez, L. Rodriguez-Manas, Y. Rolland, J. G. Ruiz, O. Theou, D. T. Villareal, D. L. Waters, C. Won Won, J. Woo, B. Vellas, M. Fiatarone Singh
Summary: The ageing process is inevitable, but can be slowed down through exercise. Exercise and physical activity play a crucial role in preventing chronic diseases, improving quality of life, and reducing mortality among older adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Review
Oncology
Stephanie Sembill, Maria Ampatzidou, Sonali Chaudhury, Michael Dworzak, Krzysztof Kalwak, Axel Karow, Alexander Kiani, Manuela Krumbholz, Maaike Luesink, Nora Naumann-Bartsch, Barbara De Moerloose, Michael Osborn, Kirk R. Schultz, Petr Sedlacek, Fiorina Giona, Christian Michel Zwaan, Hiroyuki Shimada, Birgitta Versluijs, Frederic Millot, Nobuko Hijiya, Meinolf Suttorp, Markus Metzler
Summary: The treatment of chronic myeloid leukemia has improved with the use of tyrosine kinase inhibitors; however, the prognosis for CML in the blast phase remains poor and treatment options are limited. In order to provide consistent therapy for children and adolescents with this high-risk disease, an international panel of pediatric CML experts developed recommendations based on current literature and national standards.
Article
Clinical Neurology
Rajesh Pahwa, Stuart H. Isaacson, Gary W. Small, Yasar Torres-Yaghi, Fernando Pagan, Marwan Sabbagh
Summary: Hallucinations and delusions are debilitating non-motor symptoms in Parkinson's disease, but often go unreported. A panel of experts developed a simple screening tool and treatment guidance to assist in the diagnosis and management of Parkinson's disease psychosis.
NEUROLOGY AND THERAPY
(2022)
Article
Dermatology
Emmilia Hodak, Larisa Geskin, Emmanuella Guenova, Pablo L. Ortiz-Romero, Rein Willemze, Jie Zheng, Richard Cowan, Francine Foss, Cristina Mangas, Christiane Querfeld
Summary: Mycosis fungoides (MF) is a rare, primary cutaneous T-cell lymphoma that is challenging to diagnose. An international expert panel convened to discuss barriers to early diagnosis and provide guidance for clinicians.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Review
Clinical Neurology
Monica P. Mallampalli, Habib G. Rizk, Amir Kheradmand, Shin C. Beh, Mehdi Abouzari, Alaina M. Bassett, James Buskirk, Claire E. J. Ceriani, Matthew G. Crowson, Hamid Djalilian, Joel A. Goebel, Jeffery J. Kuhn, Anne E. Luebke, Marco Mandala, Magdalena Nowaczewska, Nicole Spare, Roberto Teggi, Maurizio Versino, Hsiangkuo Yuan, Ashley Zaleski-King, Michael Teixido, Frederick Godley
Summary: Vestibular migraine is increasingly recognized as a pathological cause of vestibular disorders, yet it remains underdiagnosed. The pathophysiology of this disorder is still unclear. A multidisciplinary expert workshop identified seven current care gaps that need to be resolved, including a better understanding of symptoms and phenotypes, a lack of diagnostic markers, a better understanding of pathophysiological mechanisms, as well as the need for clear recommendations and outcome measures. Recommendations were made to address these gaps, such as establishing a global registry and conducting trials to validate current treatments.
FRONTIERS IN NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Dan Ziegler, Solomon Tesfaye, Vincenza Spallone, Irina Gurieva, Juma Al Kaabi, Boris Mankovsky, Emil Martinka, Gabriela Radulian, Khue Thy Nguyen, Alin O. Stirban, Tsvetalina Tankova, Tamas Varkonyi, Roy Freeman, Peter Kempler, Andrew J. M. Boulton
Summary: Diabetic sensorimotor polyneuropathy (DSPN) is a common condition in diabetes patients, affecting around one third of them. It can lead to various complications and has significant impact on patients' lives. However, it is often inadequately diagnosed and treated. This article provides expert consensus recommendations and algorithms for the screening, diagnosis, and treatment of DSPN, aiming to improve patients' quality of life.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anton S. Becker, Rocio Perez-Johnston, Sona A. Chikarmane, Melissa M. Chen, Maria El Homsi, Kimberly N. Feigin, Katherine M. Gallagher, Ehab Y. Hanna, Marshall Hicks, Ahmet T. Ilica, Erica L. Mayer, Atul B. Shinagare, Randy Yeh, Marius E. Mayerhoefer, Hedvig Hricak, H. Alberto Vargas
Summary: Vaccination-associated adenopathy is a common imaging finding after COVID-19 vaccination, which may be mistaken for malignant nodal involvement in patients with cancer. Routine imaging should be scheduled at least 6 weeks after vaccination, while clinically indicated imaging should not be delayed.
Review
Rehabilitation
Sara C. Parke, Amy Ng, Patrick Martone, Lynn H. Gerber, David S. Zucker, Jessica Engle, Ekta Gupta, Katherine Power, Jonas Sokolof, Sam Shapar, Leslie Bagay, Bruce E. Becker, David Michael Langelier
Summary: The 2019 ACSM articles provide important updates on exercise for cancer patients, offering evidence-based recommendations for specific cancer populations to be implemented broadly in rehabilitation practice. The impact of these articles is significant in the field of cancer rehabilitation medicine.
Review
Clinical Neurology
J. C. Le Huec, S. AlEissa, A. J. Bowey, B. Debono, A. El-Shawarbi, N. Fernandez-Baillo, K. S. Han, A. Martin-Benlloch, R. Pflugmacher, P. Sabatier, D. Vanni, I Walker, T. Warren, S. Litrico
Summary: Bleeding in spine surgery is a common occurrence, but uncontrolled bleeding can have severe consequences. Various factors, including patient factors and surgical approach, can influence bleeding during spine surgery. Hemostatic agents can be used to reduce bleeding risk, but evidence supporting their use in spine surgery is limited.
Article
Dermatology
Julien Seneschal, Reinhart Speeckaert, Alain Taieb, Albert Wolkerstorfer, Thierry Passeron, Amit G. Pandya, Henry W. Lim, Khaled Ezzedine, Youwen Zhou, Flora Xiang, Steven Thng, Atsushi Tanemura, Tamio Suzuki, David Rosmarin, Michelle Rodrigues, Noufal Raboobee, Georg Pliszewski, Davinder Parsad, Naoki Oiso, Paul Monteiro, Jean Marie Meurant, Nicolle Maquignon, Harvey Lui, Caroline Le Poole, Giovanni Leone, Ai-Young Lee, Eric Lan, Ichiro Katayama, Richard Huggins, Sang Ho Oh, John E. Harris, Iltefat H. Hamzavi, Somesh Gupta, Pearl Grimes, Boon Kee Goh, Deepti Ghia, Samia Esmat, Viktoria Eleftheriadou, Markus Boehm, Laila Benzekri, Marcel Bekkenk, Jung Min Bae, Augustin Alomar, Marwa Abdallah, Mauro Picardo, Nanja Van Geel
Summary: This study presents internationally agreed-upon expert-based recommendations for the treatment of vitiligo, including the use of topical and systemic therapies, phototherapies, intervention strategies, and the status of innovative therapies. The development of new treatments for vitiligo is ongoing.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
T. Passeron, H. W. Lim, C. -L. Goh, H. Y. Kang, F. Ly, A. Morita, J. Ocampo Candiani, S. Puig, S. Schalka, L. Wei, B. Dreno, J. Krutmann
Summary: Tailored recommendations of sunscreen are essential based on the impact of different wavelengths of sunlight on the skin and the specific skin phototype and dermatoses. Advances in sunscreen filters and formulations have made this customization possible. Effective protection against various skin issues like photoaging and skin cancers can be achieved by selecting the appropriate sunscreen for each skin type.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ulrike von Arnim, Luc Biedermann, Seema S. Aceves, Peter A. Bonis, Margaret H. Collins, Evan S. Dellon, Glenn T. Furuta, Nirmala Gonsalves, Sandeep Gupta, Ikuo Hirano, Alfredo J. Lucendo, Stephan Miehlke, Salvatore Oliva, Christoph Schlag, Alain Schoepfer, Alex Straumann, Michael Vieth, Albert J. Bredenoord, EUREOS TIGERs
Summary: This study aims to provide guidance on monitoring strategies for patients with EoE. Regular and structured clinical follow-up is recommended to assess disease activity, while maintenance treatment and personalized therapy are effective in reducing complications.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Clinical Neurology
David Adams, Yukio Ando, Joao Melo Beirao, Teresa Coelho, Morie A. Gertz, Julian D. Gillmore, Philip N. Hawkins, Isabelle Lousada, Ole B. Suhr, Giampaolo Merlini
Summary: ATTR amyloidosis with PN is a severe hereditary disease that primarily affects the nervous system, with a variety of symptoms that may vary among individuals. Early diagnosis is crucial for effective management and treatment.
JOURNAL OF NEUROLOGY
(2021)
Article
Hematology
Maximilian Stahl, Andriy Derkach, Noushin Farnoud, Jan Philipp Bewersdorf, Troy Robinson, Christopher Famulare, Christina Cho, Sean Devlin, Kamal Menghrajani, Minal A. Patel, Sheng F. Cai, Linde A. Miles, Robert L. Bowman, Mark B. Geyer, Andrew Dunbar, Zachary D. Epstein-Peterson, Erin McGovern, Jessica Schulman, Jacob L. Glass, Justin Taylor, Aaron D. Viny, Eytan M. Stein, Bartlomiej Getta, Maria E. Arcila, Qi Gao, Juliet Barker, Brian C. Shaffer, Esperanza B. Papadopoulos, Boglarka Gyurkocza, Miguel-Angel Perales, Omar Abdel-Wahab, Ross L. Levine, Sergio A. Giralt, Yanming Zhang, Wenbin Xiao, Nidhi Pai, Elli Papaemmanuil, Martin S. Tallman, Mikhail Roshal, Aaron D. Goldberg
Summary: Measurable residual disease (MRD) is a powerful prognostic factor in acute myeloid leukemia (AML). This study aims to identify pre-treatment molecular predictors of immunophenotypic MRD clearance in AML patients. The results showed that induction chemotherapy led to different MRD responses, with 35% achieving MRD- remission, 27% achieving MRD+ remission, and 38% having persistent disease. Subsequent therapy resulted in MRD conversion in 34% of MRD+ patients and 26% of patients with persistent disease. Specific gene mutations and karyotypic abnormalities were found to be associated with high or low rates of MRD- remission. Patients with fewer individual clones were more likely to achieve MRD- remission. Furthermore, the study demonstrated that achieving MRD- prior to allogeneic stem cell transplant (allo-SCT) was associated with favorable outcomes. Therefore, the inclusion of patients with specific baseline mutational patterns and high clone numbers in clinical trials should be considered.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Volker Arndt, Daniela Doege, Stefan Froehling, Peter Albers, Hana Alguel, Ralf Bargou, Carsten Bokemeyer, Martin Bornhaeuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Bruemmendorf, Hartmut Doehner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann
Summary: The capacities of German Comprehensive Cancer Centers (CCCs) in various aspects of oncology care were significantly affected during the first 2 years of the COVID-19 pandemic. Follow-up, psycho-oncologic care, and tumor surgery were particularly impacted, along with other areas of multidisciplinary oncological care. This study highlights the importance of developing strategies to prevent similar limitations in the future.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Letter
Hematology
Andrew H. Wei, Hartmut Doehner, Hamid Sayar, Farhad Ravandi, Pau Montesinos, Herve Dombret, Dominik Selleslag, Kimmo Porkka, Jun-Ho Jang, Barry Skikne, C. L. Beach, Thomas Prebet, George Zhang, Alberto Risueno, Manuel Ugidos, Wendy L. See, Daniel Menezes, Gail J. Roboz
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Hematology
Fatima Zahra Jelloul, Mark. J. Routbort, Courtney D. DiNardo, Carlos E. Bueso-Ramos, Rashmi Kanagal-Shamanna, Beenu Thakral, Zhuang Zuo, C. Cameron Yin, Sanam Loghavi, Chi Young. Ok, Sa A. Wang, Zhenya Tang, M. James You, Keyur P. Patel, L. Jeffrey Medeiros, Andres E. Quesada
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Hematology
Courtney D. DiNardo, Stephane De Botton, Daniel A. Pollyea, Richard M. Stone, Jessica K. Altman, Amir T. Fathi, Tharin Limsakun, Min Liang, Sung Choe, Mohammad Hossain, Adriana E. Tron, Qian Meng, Stephanie M. Kapsalis, Shuchi S. Pandya, Eytan M. Stein
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Alexandre Bazinet, Hagop Kantarjian, Naszrin Arani, Uday Popat, Alex Bataller, Koji Sasaki, Courtney D. DiNardo, Naval Daver, Musa Yilmaz, Hussein A. Abbas, Nicholas J. Short, Ghayas Issa, Elias Jabbour, Sherry A. Pierce, Julianne Chen, Ricky Garcia, Marina Konopleva, Guillermo Garcia-Manero, Amin Alousi, Elizabeth J. Shpall, Richard E. Champlin, Gautam Borthakur, Farhad Ravandi, Tapan Kadia
Summary: This study retrospectively evaluated the contemporary outcomes of older patients with acute myeloid leukemia (AML). The results showed that low-intensity therapy (LIT) and stem cell transplantation (SCT) have improved the treatment outcomes for this population. The study also identified common adverse clinical and cytogenetic findings in older AML patients. Measures should be taken to increase access to SCT for older AML patients.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Andrew J. Dunbar, Dongjoo Kim, Min Lu, Mirko Farina, Robert L. Bowman, Julie L. Yang, Young Park, Abdul Karzai, Wenbin Xiao, Zach Zaroogian, Kavi O'Connor, Shoron Mowla, Francesca Gobbo, Paola Verachi, Fabrizio Martelli, Giuseppe Sarli, Lijuan Xia, Nada Elmansy, Maria Kleppe, Zhuo Chen, Yang Xiao, Erin McGovern, Jenna Snyder, Aishwarya Krishnan, Corrine Hill, Keith Cordner, Anouar Zouak, Mohamed E. Salama, Jayden Yohai, Eric Tucker, Jonathan Chen, Jing Zhou, Timothy McConnell, Anna R. Migliaccio, Richard Koche, Raajit Rampal, Rong Fan, Ross L. Levine, Ronald Hoffman
Summary: Inflammatory signaling is crucial in the development of myelofibrosis (MF), a type of cancer. Recent studies have identified the involvement of JAK/STAT and NF-kappa B signaling in MF progression. This study further explores the role of CXCL8/CXCR2 signaling in MF pathogenesis, and highlights its potential as a therapeutic target.
Letter
Oncology
Frank Stegelmann, Lino L. Teichmann, Florian H. Heidel, Carl C. Crodel, Thomas Ernst, Sebastian Kreil, Andreas Reiter, Sara Otten, Stefanie Schauer, Ruth-Miriam Korber, Kim Kricheldorf, Susanne Isfort, Hartmut Doehner, Tim H. H. Bruemmendorf, Martin Griesshammer, Konstanze Doehner, Steffen Koschmieder
Review
Oncology
Curtis A. Lachowiez, Courtney D. DiNardo, Sanam Loghavi
Summary: This review summarizes the current landscape of molecularly targeted therapies for patients with acute myeloid leukemia (AML) who have IDH1/2 or FLT3 mutations. The development of targeted therapeutics has improved the treatment options and survival outcomes for AML patients. In addition to approved therapies, ongoing clinical trials are investigating new targeted therapies for specific patient subgroups, in order to overcome treatment resistance.
Article
Oncology
Adriana Trabal, Amber Gibson, Jiasen He, David McCall, Michael Roth, Cesar Nunez, Miriam Garcia, Meredith Buzbee, Laurie Toepfer, Aram Bidikian, Naval Daver, Tapan Kadia, Nicholas J. Short, Ghayas C. Issa, Farhad Ravandi, Courtney D. DiNardo, Guillermo Montalban Bravo, Sofia Garces, Andrea Marcogliese, Hana Paek, Zoann Dreyer, Julienne Brackett, Michele Redell, Joanna Yi, Guillermo Garcia-Manero, Marina Konopleva, Alexandra Stevens, Branko Cuglievan
Summary: This article describes the experience of using venetoclax in combination with various therapies for the treatment of pediatric relapsed acute myeloid leukemia (AML) at the Texas Medical Center. The safety and efficacy of this regimen in this population are reported. Evaluation: 8 points
Article
Hematology
Nicholas J. Short, Faustine Ong, Farhad Ravandi, Graciela Nogueras-Gonzalez, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Marina Konopleva, Gautam Borthakur, Betul Oran, Gheath Al-Atrash, Rohtesh Mehta, Elias J. Jabbour, Musa Yilmaz, Ghayas C. Issa, Abhishek Maiti, Richard E. Champlin, Hagop Kantarjian, Elizabeth J. Shpall, Uday Popat
Summary: Although venetoclax-based lower-intensity regimens have greatly improved outcomes for older adults with acute myeloid leukemia (AML) who are unfit for intensive chemotherapy, the optimal induction for older patients with newly diagnosed AML who are suitable candidates for hematopoietic stem cell transplant (HSCT) is controversial.
Article
Oncology
Koji Sasaki, Farhad Ravandi, Courtney Dinardo, Mary Alma Welch, Tapan Kadia, Hagop Kantarjian
Summary: Early mortality is an important measure of quality of care, but previous studies did not take into account the impact of disease characteristics and treatment status. This study found that salvage therapy in acute myeloid leukemia patients is associated with significantly higher 8-week mortality, even after accounting for other adverse factors.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Article
Hematology
Jorge Sierra, Pau Montesinos, Xavier Thomas, Laimonas Griskevicius, Thomas Cluzeau, Denis Caillot, Ollivier Legrand, Clara Minotti, Mario Luppi, Firas Farkas, Bourras-Rezki Bengoudifa, Geralyn Gilotti, Sejla Hodzic, Alessandro Rambaldi, Adriano Venditti
Summary: The pivotal RATIFY study demonstrated that midostaurin combined with standard chemotherapy significantly reduced mortality in adult patients with newly diagnosed FLT3(mut) acute myeloid leukemia. This open-label, multicenter phase 3b trial aimed to further assess the safety and efficacy of midostaurin plus chemotherapy in different age groups. The results showed that the safety and efficacy of midostaurin remained consistent with previous findings regardless of age, sex, or induction regimen.
Article
Hematology
Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy N. Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Matlawska-Wasowska, Gurushankar Chandramouly, Reza Nejati, Mariusz Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard T. Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth M. Paietta, Ross L. Levine, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Gaorav P. Gupta, Jean-Yves Masson, Tomasz Skorski
Summary: Leukemia cells accumulate DNA damage, but altered DNA repair mechanisms protect them from apoptosis. Formaldehyde generated by serine/1-carbon cycle metabolism contributes to the accumulation of toxic DNA-protein crosslinks (DPCs) in leukemia cells. Oncogenic tyrosine kinases (OTKs) enhance the expression of DNA polymerase theta (POL theta) to repair DPC-containing DNA double-strand breaks. Inhibition of POL theta can be an effective therapeutic strategy for leukemia.
Article
Medicine, Research & Experimental
Santhosh Kumar Pasupuleti, Baskar Ramdas, Sarah S. Burns, Lakshmi Reddy Palam, Rahul Kanumuri, Ramesh Kumar, Taruni Reddy Pandhiri, Utpal P. Dave, Nanda Kumar Yellapu, Xinyu Zhou, Chi Zhang, George E. Sandusky, Zhi Yu, Michael C. Honigberg, Alexander G. Bick, Gabriel K. Griffin, Abhishek Niroula, Benjamin L. Ebert, Sophie Paczesny, Pradeep Natarajan, Reuben Kapur
Summary: Characterized by the accumulation of somatic mutations in blood cell lineages, clonal hematopoiesis of indeterminate potential (CHIP) is associated with obesity and could potentially be treated using targeted drugs.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
