Article
Oncology
Sophie Huybrechts, Gwenael Le Teuff, Arnault Tauziede-Espariat, Caroline Rossoni, Anais Chivet, Emilie Indersie, Pascale Varlet, Stephanie Puget, Rachid Abbas, Olivier Ayrault, Lea Guerrini-Rousseau, Jacques Grill, Dominique Valteau-Couanet, Christelle Dufour
Summary: This study aimed to identify prognostic factors for survival post-relapse in children with childhood medulloblastoma. The molecular subgroup at diagnosis, use of radiotherapy at relapse, and time to first relapse (>12 months) were found to potentially impact post-relapse survival. Improving understanding of tumor biology, timing, and type of relapse is important for optimizing treatment strategies post-relapse.
Article
Oncology
Christelle Dufour, Stephanie Foulon, Anne Geoffray, Julien Masliah-Planchon, Dominique Figarella-Branger, Valerie Bernier-Chastagner, Laetitia Padovani, Lea Guerrini-Rousseau, Cecile Faure-Conter, Celine Icher, Anne-Isabelle Bertozzi, Pierre Leblond, Tasnime Akbaraly, Franck Bourdeaut, Nicolas Andre, Celine Chappe, Pascale Schneider, Emilie De Carli, Pascal Chastagner, Claire Berger, Julien Lejeune, Christine Soler, Natacha Entz-Werle, Marie-Bernadette Delisle
Summary: This study assessed the efficacy of a treatment regimen involving high-dose chemotherapy and conventional radiotherapy for children with newly diagnosed high-risk medulloblastoma. The results showed 3 and 5-year progression-free survival rates of 78% and 76% respectively, with good tolerability of the treatment regimen.
Article
Cardiac & Cardiovascular Systems
Alessia Lena, Ursula Wilkenshoff, Sara Hadzibegovic, Jan Porthun, Lukas Roesnick, Ann-Kathrin Froehlich, Tanja Zeller, Mahir Karakas, Ulrich Keller, Johann Ahn, Lars Bullinger, Hanno Riess, Stuart D. Rosen, Alexander R. Lyon, Thomas F. Luescher, Matthias Totzeck, Tienush Rassaf, Daniel Burkhoff, Mandeep R. Mehra, Jeroen J. Bax, Javed Butler, Frank Edelmann, Wilhelm Haverkamp, Stefan D. Anker, Milton Packer, Andrew J. S. Coats, Stephan von Haehling, Ulf Landmesser, Markus S. Anker
Summary: This study found that cancer patients have cardiac wasting and decreased heart function. Low left ventricular mass is associated with poor functional status and increased all-cause mortality in cancer patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Charikleia Ntenti, Konstantinos Lallas, Georgios Papazisis
Summary: Medulloblastomas, highly aggressive neoplasms of the central nervous system, show significant heterogeneity in clinical presentation, disease course, and treatment outcomes. They are classified into four subgroups based on genetic and transcriptomic studies, but recent molecular findings have led to further stratification and changes in treatment management. This review discusses histological, clinical, and molecular prognostic factors for better characterization, prognostication, and treatment of medulloblastomas.
Article
Cell Biology
Andrea Martins-da-Silva, Mirella Baroni, Karina Bezerra Salomao, Pablo Ferreira das Chagas, Ricardo Bonfim-Silva, Lenisa Geron, Gustavo Alencastro Veiga Cruzeiro, Wilson Araujo da Silva Jr, Carolina Alves Pereira Correa, Carlos Gilberto Carlotti Jr, Rosane Gomes de Paula Queiroz, Suely Kazue Nagahashi Marie, Silvia Regina Brandalise, Jose Andres Yunes, Carlos Alberto Scrideli, Elvis Terci Valera, Luiz Gonzaga Tone
Summary: This research identified five hub genes associated with prognosis in pediatric MB samples, which are involved in important pathways and functions, and control cell stemness and pluripotency.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Oncology
Yang Yang, Jinyan Yuan, Zhenzhong Liu, Wenwen Cao, Pei Liu
Summary: CCA patients with high expression of HJURP have lower overall survival rates, specifically in iCCA and pCCA. HJURP serves as an independent prognostic biomarker in iCCA and pCCA, but not in dCCA. This study provides further evidence of the molecular features of different CCA subsets and suggests that HJURP can guide precision follow-up and treatment for CCA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Revathi Rajagopal, Ay Jiuan Teng, Vida Jawin, Oy Leng Wong, Hakimah Mahsin, Nor Haizura Abd Rani, Tsiao Yi Yap, Kogilavani Gunasagaran, Asohan Thevarajah, Seoh Leng Yeoh, Gek Bee Ong, Hany Ariffin, David Jones, Eric Bouffet, Nicholas G. Gottardo
Summary: This study examines the diagnostic accuracy and prognostic significance of DNA methylation profiling in medulloblastoma. The results show that most infants have the SHH molecular subgroup, and their prognosis is comparable to that reported in high-income countries. However, due to the relatively small sample size and high treatment abandonment rate, definite conclusions cannot be drawn regarding the prognostic significance of medulloblastoma molecular subgroups.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Shi-sen Wang, Zi-jun Xu, Ye Jin, Ji-chun Ma, Pei-hui Xia, Xiangmei Wen, Zhen-wei Mao, Jiang Lin, Jun Qian
Summary: The study found that CXCL12 expression is significantly reduced in AML, and low CXCL12 expression is correlated with worse prognosis, predicting decreased overall survival and event-free survival rates.
Review
Medicine, General & Internal
Carlo Caffarelli, Arianna Giannetti, Giuliana Gianni, Giampaolo Ricci
Summary: This article summarizes the pathogenesis of atopic dermatitis (AD) and discusses new drugs for the treatment of skin inflammation. It also highlights the clinical efficacy of biologics and small molecules.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Alison L. Cameron, Markus C. Elze, Michela Casanova, Birgit Geoerger, Mark N. Gaze, Veronique Minard-Colin, Kieran McHugh, Rick R. van Rijn, Anna Kelsey, Helene Martelli, Henry Mandeville, Gianni Bisogno, Stephen Lowis, Milind Ronghe, Daniel Orbach, Cecile Guizani, Sabine Furst-Recktenwald, Julia C. Chisholm, Johannes H. M. Merks
Summary: This study retrospectively evaluated the impact of radiation therapy on survival in children with metastatic rhabdomyosarcoma. Radical irradiation was associated with improved overall survival compared to no irradiation, with radical irradiation also showing significantly greater OS compared to partial irradiation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Respiratory System
Katarina Zeder, Chiara Banfi, Gregor Steinrisser-Allex, Bradley A. Maron, Marc Humbert, Gregory D. Lewis, Andrea Berghold, Horst Olschewski, Gabor Kovacs
Summary: This study aimed to identify parameters related to abnormal haemodynamic response during exercise, and provide optimal prognostic and differential-diagnostic value. The findings indicated that mPAP/CO slope, PAWP/CO slope, and peak cardiac index (or CO) were the most consistent prognostic haemodynamic parameters. The study also established cut-off values for survival and cardiovascular events. Age was found to have a significant impact on the upper limits of normal for mPAP/CO slope and PAWP/CO slope.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Oncology
Qiwei Liu, Zhen Li, Lizhao He, Ke Li, Chen Hu, Jialiang Chen, Fangjian Zhou, Jun Wang, Yonghong Li, Hengjun Xiao
Summary: Prostate cancer is a common malignancy in men worldwide. The N6-methylation of adenosine (m6A) plays a crucial role in metastatic prostate cancer. High m6A score is associated with poor prognosis and higher scores in cell cycle, DNA repair, and mismatch repair pathways. Additionally, the m6Ascore model based on m6A regulators can predict the prognosis of patients with metastatic prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Laura Pizzuti, Maddalena Barba, Marco Mazzotta, Eriseld Krasniqi, Marcello Maugeri-Sacca, Teresa Gamucci, Rossana Berardi, Lorenzo Livi, Corrado Ficorella, Clara Natoli, Enrico Cortesi, Daniele Generali, Nicla La Verde, Alessandra Cassano, Emilio Bria, Luca Moscetti, Andrea Michelotti, Vincenzo Adamo, Claudio Zamagni, Giuseppe Tonini, Domenico Sergi, Daniele Marinelli, Giancarlo Paoletti, Silverio Tomao, Andrea Botticelli, Paolo Marchetti, Nicola Tinari, Antonino Grassadonia, Maria Rosaria Valerio, Rosanna Mirabelli, Maria Agnese Fabbri, Nicola D'Ostilio, Enzo Veltri, Domenico Corsi, Ornella Garrone, Ida Paris, Giuseppina Sarobba, Icro Meattini, Mirco Pistelli, Francesco Giotta, Vito Lorusso, Carlo Garufi, Antonio Russo, Marina Cazzaniga, Pietro Del Medico, Mario Roselli, Angela Vaccaro, Letizia Perracchio, Anna di Benedetto, Theodora Daralioti, Isabella Sperduti, Ruggero De Maria, Angelo Di Leo, Giuseppe Sanguineti, Gennaro Ciliberto, Patrizia Vici
Summary: The study found that patients with HER2-positive mBC with discordant HER2 status in early BC may have different clinical, biological, and prognostic behavior compared to HER2-concordant patients. These patients showed higher expression of estrogen and/or progesterone receptor, lower rate of brain metastases, and longer disease-free interval.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Aleix Prat, Fara Braso-Maristany, Olga Martinez-Saez, Esther Sanfeliu, Youli Xia, Meritxell Bellet, Patricia Galvan, Debora Martinez, Tomas Pascual, Mercedes Marin-Aguilera, Anna Rodriguez, Nuria Chic, Barbara Adamo, Laia Pare, Maria Vidal, Mireia Margeli, Ester Ballana, Marina Gomez-Rey, Mafalda Oliveira, Eudald Felip, Judit Matito, Rodrigo Sanchez-Bayona, Anna Sunol, Cristina Saura, Eva Ciruelos, Pablo Tolosa, Montserrat Munoz, Blanca Gonzalez-Farre, Patricia Villagrasa, Joel S. Parker, Charles M. Perou, Ana Vivancos
Summary: This study uses shallow WGS to create machine learning signatures to identify tumor phenotypes and predict therapy response in metastatic breast cancer patients. Machine learning multi-gene signatures obtained from ctDNA can identify complex biological features similar to those obtained from direct tumor tissue DNA or RNA profiling.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Ewa Koscielniak, Bernd Blank, Christian Vokuhl, Bernarda Kazanowska, Ruth Ladenstein, Felix Niggli, Gustaf Ljungman, Rupert Handgretinger, Guido Seitz, Joerg Fuchs, Birgit Froehlich, Monika Scheer, Ruediger Wessalowski, Irene Schmid, Monika Sparber-Sauer, Thomas Klingebiel
Summary: The CWS-2002P study focused on adapting therapy burden to risk profile in pediatric oncology to achieve optimal outcomes with minimal toxicities. The risk stratification system effectively predicted long-term results, regardless of chemotherapy reduction or intensification. Maintenance therapy appeared to impact prognosis, suggesting the need for further investigation in a well-controlled prospective trial.
Article
Oncology
Lisa Roesch, Sonja Herter, Sara Najafi, Johannes Ridinger, Heike Peterziel, Jindrich Cinatl, David T. W. Jones, Martin Michaelis, Olaf Witt, Ina Oehme
Summary: Chemotherapy resistance is a persistent problem in neuroblastomas. Tariquidar and afatinib were identified as effective inhibitors of drug resistance in neuroblastoma cells.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Florian Selt, Romain Sigaud, Gintvile Valinciute, Philipp Sievers, Julia Zaman, Clara Alco, Simone Schmid, Heike Peterziel, Jessica W. Tsai, Romain Guiho, Juan Pedro Martinez-Barbera, Stefan Pusch, Jing Deng, Yifan Zhai, Cornelis M. van Tilburg, Martin U. Schuhman, Ahmed E. L. Damaty, Pratiti Bandopadhayay, Christel Herold-Mende, Andreas von Deimling, Stefan M. Pfister, Joan Montero, David Capper, Ina Oehme, Felix Sahm, David T. W. Jones, Olaf Witt, Till Milde
Summary: Our study demonstrates that BCL-XL is critical for the survival of senescent PA tumor cells and provides evidence for the use of clinically available BCL-XL-dependent senolytic agents.
Article
Clinical Neurology
Martin Mynarek, Denise Obrecht, Martin Sill, Dominik Sturm, Katja Kloth-Stachnau, Florian Selt, Jonas Ecker, Katja von Hoff, Bjoern-Ole Juhnke, Tobias Goschzik, Torsten Pietsch, Michael Bockmayr, Marcel Kool, Andreas von Deimling, Olaf Witt, Ulrich Schuller, Martin Benesch, Nicolas U. Gerber, Felix Sahm, David T. W. Jones, Andrey Korshunov, Stefan M. Pfister, Stefan Rutkowski, Till Milde
Summary: This study investigates the integration of clinical and molecular parameters to improve risk stratification of non-WNT/non-SHH medulloblastoma (MB). The combination of subgroup and whole-chromosomal aberration (WCA) phenotype was found to be the best predictor of disease progression and death. The identification of low-risk and very high-risk strata through the integration of clinical and molecular variables may improve future treatment stratification.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schuller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
Summary: Pediatric central nervous system (CNS) tumors are the leading cause of cancer-related death in children aged 0-14 years. A newly identified CNS tumor type characterized by PLAGL1/2 amplification and a lack of recurrent genetic alterations has been described. These tumors are composed of primitive embryonal-like cells and are associated with intermediate survival, but the cell of origin and optimal treatment strategies are yet to be determined.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Maximilian Deng, Felix Hinz, Semi Harrabi, Dominik Sturm, Martin Sill, Andrey Korshunov, Tanja Eichkorn, Juliane Hoerner-Rieber, Klaus Herfarth, Christine Jungk, Andreas Unterberg, Stefan Pfister, Wolfgang Wick, Andreas von Deimling, David Jones, Juergen Debus, Felix Sahm, Laila Koenig
Summary: Molecular brain tumor classification using DNA methylation profiling has revealed that the methylation-class of pleomorphic xanthoastrocytoma (mcPXA) comprised a substantial portion of divergent initial diagnoses. This study aimed to characterize the survival outcome in patients with mcPXAs and determine the benefit of postoperative radiotherapy. The results demonstrated that adult patients with mcPXAs display a worse progression-free survival compared to the reported WHO grade 2 PXAs.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Oncology
Venu Thatikonda, S. M. Ashiqul Islam, Robert J. Autry, Barbara C. Jones, Susanne N. Groebner, Gregor Warsow, Barbara Hutter, Daniel Huebschmann, Stefan Froehling, Marcel Kool, Mirjam Blattner-Johnson, David T. W. Jones, Ludmil B. Alexandrov, Stefan M. Pfister, Natalie Jaeger
Summary: Jager and colleagues analyzed the mutational patterns in pediatric cancers and found marked differences compared to adult cancers, providing insights into molecular mechanisms. They identified a small number of mutational signatures specific to pediatric cancers and discovered a previously unreported indel signature in pediatric leukemias. This study provides a systematic overview of mutational signatures in pediatric cancers, which is highly relevant for understanding tumor biology and developing biomarkers for treatment response.
Correction
Clinical Neurology
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schueller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Henri Bogumil, Martin Sill, Daniel Schrimpf, Britta Ismer, Christina Blume, Ramin Rahmanzade, Felix Hinz, Asan Cherkezov, Rouzbeh Banan, Dennis Friedel, David E. Reuss, Florian Selt, Jonas Ecker, Till Milde, Kristian W. Pajtler, Jens Schittenhelm, Jürgen Hench, Stephan Frank, Henning B. Boldt, Bjarne Winther Kristensen, David Scheie, Linea C. Melchior, Viola Olesen, Astrid Sehested, Daniel R. Boue, Zied Abdullaev, Laveniya Satgunaseelan, Ina Kurth, Annekatrin Seidlitz, Christine L. White, Ho-Keung Ng, Zhi-Feng Shi, Christine Haberler, Martina Deckert, Marco Timmer, Roland Goldbrunner, Arnault Tauziede-Espariat, Pascale Varlet, Sebastian Brandner, Sanda Alexandrescu, Matija Snuderl, Kenneth Aldape, Andrey Korshunov, Olaf Witt, Christel Herold-Mende, Andreas Unterberg, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, David T. W. Jones, Felix Sahm, Philipp Sievers
Summary: This study identified a new type of glioneuronal tumor with ATRX alteration, kinase fusion, and anaplastic features. The molecular characteristics of these tumors suggest potential targeted therapies, such as NTRK inhibition.
ACTA NEUROPATHOLOGICA
(2023)
Article
Oncology
Salome Christen, Katharina Roser, Erika Harju, Fabienne Gumy-Pause, Luzius Mader, Janine Vetsch, Andre O. von Bueren, Gisela Michel
Summary: This study aimed to compare worries and anxiety in parents of adult childhood cancer survivors with parents of the Swiss general population and evaluate characteristics associated with worry in parents of survivors. The results showed that most parents of adult survivors reported similar worries and anxiety as the general population parents, but cancer-related worries were still prevalent.
PEDIATRIC BLOOD & CANCER
(2023)
Letter
Clinical Neurology
Ramin Rahmanzade, Elke Pfaff, Rouzbeh Banan, Philipp Sievers, Abigail K. Suwala, Felix Hinz, Henri Bogumil, Asan Cherkezov, Aras Fuat Kaan, Daniel Schrimpf, Dennis Friedel, Kirsten Goebel, Felix Keller, Xavier Saenz-Sarda, Alexander Lossos, Martin Sill, Olaf Witt, Oliver W. Sakowitz, Andrey Korshunov, David E. Reuss, Nima Etminan, Andreas Unterberg, Miriam Ratliff, Christel Herold-Mende, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, David T. W. Jones, Felix Sahm
ACTA NEUROPATHOLOGICA
(2023)
Article
Biochemical Research Methods
Elias Ulrich, Stefan M. Pfister, Natalie Jaeger
Summary: As non-coding driver mutations become more important in cancer research, a comprehensive and user-friendly software solution for regulatory variant analysis and data visualization is highly relevant. A tool called Revana has been introduced, which can aggregate and visually represent regulatory variants from cancer genomes in a gene-centric manner. It requires whole-genome and RNA sequencing data of a tumor sample cohort and creates interactive HTML reports summarizing the most important regulatory events.
Article
Oncology
Julia Baenziger, Katharina Roser, Luzius Mader, Anica Ilic, Ursula M. Sansom-Daly, Andre O. von Bueren, Eva Maria Tinner, Gisela Michel
Summary: This study describes the post-traumatic growth (PTG) in parents of long-term childhood cancer survivors and identifies the psychological, socio-economic, and event-related characteristics associated with PTG. The findings show that mothers and fathers can experience growth many years after their child's illness, and being able to foresee new possibilities and personal development may help support parents in developing a sense of hope.
Article
Oncology
Leopold Pirson, Sonja C. Luer, Manuel Diezi, Sabine Kroiss, Pierluigi Brazzola, Freimut H. Schilling, Nicolas von der Weid, Katrin Scheinemann, Jeanette Greiner, Tycho Jan Zuzak, Andre O. von Bueren
Summary: Pediatric oncologists in Switzerland recognize the importance of complementary therapies and are willing to acquire more knowledge on the subject. However, they generally lack knowledge and specific training opportunities on complementary medicine.