Exploration of naphthoquinone analogs in targeting the TCF-DNA interaction to inhibit the Wnt/β-catenin signaling pathway

Development of structure-based pharmacophore to target the β-catenin-TCF protein–protein interaction

(2021) Piyusha P. Pagare et al.   MEDICINAL CHEMISTRY RESEARCH

FOSL1 promotes metastasis of head and neck squamous cell carcinoma through super-enhancer-driven transcription program

(2021) Ming Zhang et al.   MOLECULAR THERAPY

Drugging the ‘undruggable’. Therapeutic targeting of protein–DNA interactions with the use of computer-aided drug discovery methods

(2021) Mariia Radaeva et al.   DRUG DISCOVERY TODAY

OB-Folds and Genome Maintenance: Targeting Protein–DNA Interactions for Cancer Therapy

(2021) Sui Par et al.   Cancers

Establishment of patient-derived cancer organoids for drug-screening applications

(2020) Else Driehuis et al.   Nature Protocols

IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases

(2020) Rosalie G. Hoyle et al.   MOLECULAR CANCER THERAPEUTICS

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Dual or multi-targeting inhibitors: The next generation anticancer agents

(2018) Nulgumnalli Manjunathaiah Raghavendra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Probing the canonicity of the Wnt/Wingless signaling pathway

(2017) Alexandra Franz et al.   PLoS Genetics

TCF/LEF Transcription Factors: An Update from the Internet Resources

(2016) Dusan Hrckulak et al.   Cancers

Understanding cancer and the anticancer activities of naphthoquinones – a review

(2015) Kevin W. Wellington   RSC Advances

Small Molecule Inhibitors of Wnt/β-Catenin/Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells In Vitro and In Vivo

(2015) Rajesh Kumar Gandhirajan et al.   NEOPLASIA

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF

(2014) Jurian Schuijers et al.   EMBO JOURNAL

Drugging the undruggable: Transcription therapy for cancer

(2012) Chunhong Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

TCF/LEFs and Wnt Signaling in the Nucleus

(2012) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells

(2011) Aslamuzzaman Kazi et al.   CELL CYCLE

The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets

(2011) Chandan Bhambhani et al.   EMBO JOURNAL

T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

(2011) M. L. Angus-Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors

(2009) Fatima Haggar et al.   Clinics in Colon and Rectal Surgery

A genome-wide RNAi screen for Wnt/ -catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

(2008) W. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA